The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
DNA methylation in metabolic disorders
Open accessAbstract
DNA methylation is a major epigenetic modification that controls gene expression in physiologic and pathologic states. Metabolic diseases such as diabetes and obesity are associated with profound alterations in gene expression that are caused by genetic and environmental factors. Recent reports have provided evidence that environmental factors at all ages could modify DNA methylation in somatic tissues, which suggests that DNA methylation is a more dynamic process than previously appreciated. Because of the importance of lifestyle factors in metabolic disorders, DNA methylation provides a mechanism by which environmental factors, including diet and exercise, can modify genetic predisposition to disease. This article considers the current evidence that defines a role for DNA methylation in metabolic disorders.
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“Recent developments in epigenetics may also provide the basis for a better understanding of the pathophysiological mechanisms underlying what to date we have called the Metabolic Syndrome 4, 47.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [47]
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Metadata
- Authors
- Barres, R., & Zierath, J. R.
- Affiliations
- UNSW Sydney (AU)
- ORCID
- Zierath, Juleen R
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 93
- Issue
- 4
- Pages
- 897S-900S
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2137923929
- Cited by
- 174
- References
- 42
- Citations by year
- 2026: 11 · 2025: 4 · 2024: 9 · 2023: 11 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 14 · 2018: 13 · 2017: 13 · 2016: 13 · 2015: 19 · 2014: 9 · 2013: 13 · 2012: 14
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- DNA methylation, epigenetics, metabolic disorders, diabetes mellitus, obesity, gene expression, environmental factors, diet, physical activity, genetic susceptibility
- MeSH terms
- Diet, Environment, Humans, Metabolic Diseases, Exercise, Gene Expression, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic
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