DNA methylation in metabolic disorders

Epigenetic programming by maternal behavior

Weaver, I. C. G., Cervoni, N., Champagne, F. A., D'Alessio, A. C., Sharma, S., Seckl, J. R., Dymov, S., Szyf, M., & Meaney, M. J. (2004) · Nature Neuroscience · doi:10.1038/nn1276 · Cited by 6,177

Global and societal implications of the diabetes epidemic

Zimmet, P., Alberti, K. G. M. M., & Shaw, J. (2001) · Nature · doi:10.1038/414782a · Cited by 5,883

Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673

Epigenetic differences arise during the lifetime of monozygotic twins

Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602

Perceptions of epigenetics

Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011

Epigenetic Transgenerational Actions of Endocrine Disruptors and Male Fertility

Anway, M. D., Cupp, A. S., Uzumcu, M., & Skinner, M. K. (2005) · Science · doi:10.1126/science.1108190 · Cited by 2,563

Epigenetic inheritance at the agouti locus in the mouse

Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics · doi:10.1038/15490 · Cited by 1,476

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010) · Nature · doi:10.1038/nature09491 · Cited by 1,327

Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a

Ramsahoye, B. H., Biniszkiewicz, D., Lyko, F., Clark, V. H., Bird, A. P., & Jaenisch, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5237 · Cited by 1,012

Cyclical DNA methylation of a transcriptionally active promoter

Métivier, R., Gallais, R., Tiffoche, C., Péron, C. L., Jurkowska, R., Carmouche, R. P., Ibberson, D., Baráth, P., Demay, F., Reid, G., et al. (2008) · Nature · doi:10.1038/nature06544 · Cited by 942

Intra-individual Change Over Time in DNA Methylation With Familial Clustering

Bjornsson, H. T. (2008) · JAMA · doi:10.1001/jama.299.24.2877 · Cited by 702

Transient cyclical methylation of promoter DNA

Kangaspeska, S., Stride, B. D., Métivier, R., Polycarpou‐Schwarz, M., Ibberson, D., Carmouche, R. P., Beneš, V., Gannon, F., & Reid, G. (2008) · Nature · doi:10.1038/nature06640 · Cited by 650

Non-CpG methylation of the PGC-1α promoter through DNMT3B controls mitochondrial density.

Barrès, R., Osler, M. E., Yan, J., Rune, A., Fritz, T., Caidahl, K., Krook, A., & Zierath, J. R. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.011 · Cited by 602

The double puzzle of diabetes

Diamond, J. M. (2003) · Nature · doi:10.1038/423599a · Cited by 477

DNA methylation and gene expression differences in children conceived in vitro or in vivo

Katari, S., Turan, N., Bibikova, M. V., Erinle, O., Chalian, R. A., Foster, M., Gaughan, J. P., Coutifaris, C., & Sapienza, C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp319 · Cited by 470

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

Plagemann, A., Harder, T., Brunn, M., Harder, A., Roepke, K., Wittrock‐Staar, M., Ziska, T., Schellong, K., Rodekamp, E., Melchior, K., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176156 · Cited by 439

Insulin Gene Expression Is Regulated by DNA Methylation

Kuroda, A., Rauch, T. A., Todorov, I., Ku, H. T., Al-Abdullah, I. H., KANDEEL, F. R., Mullen, Y., Pfeifer, G. P., & Ferreri, K. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006953 · Cited by 327

Gene Expression of GLUT4 in Skeletal Muscle From Insulin-Resistant Patients With Obesity, IGT, GDM, and NIDDM

Garvey, W. T., Maianu, L., Hancock, J. A., Golichowski, A. M., & Baron, A. (1992) · Diabetes · doi:10.2337/diab.41.4.465 · Cited by 289

Epigenetics and the Environment

Sutherland, J. E., & Costa, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb05970.x · Cited by 265

DNA Methylation and Cancer

Jones, P. A. (2000) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-59696-4 · Cited by 259

Expression of the peroxisome proliferator activated receptor γ gene is repressed by DNA methylation in visceral adipose tissue of mouse models of diabetes

Fujiki, K., Kano, F., Shiota, K., & Murata, M. (2009) · BMC Biology · doi:10.1186/1741-7007-7-38 · Cited by 244

A Folate- and Methyl-Deficient Diet Alters the Expression of DNA Methyltransferases and Methyl CpG Binding Proteins Involved in Epigenetic Gene Silencing in Livers of F344 Rats

Ghoshal, K., Li, X., Datta, J., Bai, S., Pogribny, I. P., Pogribny, M., Huang, Y., Young, D., & Jacob, S. T. (2006) · Journal of Nutrition · doi:10.1093/jn/136.6.1522 · Cited by 200

Deoxyribonucleic Acid Methylation and Gene Expression of PPARGC1A in Human Muscle Is Influenced by High-Fat Overfeeding in a Birth-Weight-Dependent Manner

Brøns, C., Jacobsen, S. B., Nilsson, E., Rönn, T., Jensen, C. B., Storgaard, H., Poulsen, P., Groop, L., Ling, C., Astrup, A. V., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2413 · Cited by 196

Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

Ling, C., Poulsen, P., Simonsson, S., Rönn, T., Holmkvist, J., Almgren, P., Hagert, P., Nilsson, E., Mabey, A. G., Nilsson, P. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30938 · Cited by 195

Evidence for cytosine methylation of non‐symmetrical sequences in transgenic Petunia hybrida.

Meyer, P., Niedenhof, I., & ten Lohuis, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06483.x · Cited by 190

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

Pogribny, I. P., Ross, S. A., Wise, C., Pogribna, M., Jones, E. A., Tryndyak, V., James, S. J., Dragan, Y. P., & Poirier, L. A. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.028 · Cited by 182

Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle.

Rönn, T., Poulsen, P., Hansson, O., Holmkvist, J., Almgren, P., Nilsson, P., Tuomi, T., Isomaa, B., Groop, L., Vaag, A., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1018-8 · Cited by 175

Multiple mechanisms induce transcriptional silencing of a subset of genes, including oestrogen receptor α, in response to deacetylase inhibition by valproic acid and trichostatin A

Reid, G., Métivier, R., Lin, C., Denger, S., Ibberson, D., Ivacevic, T., Brand, H., Beneš, V., Liu, E. T., & Gannon, F. (2005) · Oncogene · doi:10.1038/sj.onc.1208662 · Cited by 154

The Diabetic Phenotype Is Conserved in Myotubes Established From Diabetic Subjects

Gaster, M., Petersen, I. M., Højlund, K., Poulsen, P., & Beck‐Nielsen, H. (2002) · Diabetes · doi:10.2337/diabetes.51.4.921 · Cited by 150

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms.

Henry, R. R., Ciaraldi, T. P., Abrams-Carter, L., Mudaliar, S. R., Park, K., & Nikoulina, S. E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118906 · Cited by 129

The majority of methylated deoxycytidines in human DNA are not in the CpG dinucleotide

Woodcock, D. M., Crowther, P. J., & Diver, W. P. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(87)91048-5 · Cited by 128

Identifying 5-methylcytosine and related modifications in DNA genomes

Rein, T., DePamphilis, M. L., & Zorbas, H. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.10.2255 · Cited by 109

DNA Methylation and Cancer

ADAMS, R. L. P., & Burdon, R. H. (1985) · Springer series in molecular biology · doi:10.1007/978-1-4612-5130-9_10 · Cited by 105

DNA demethylation during the differentiation of 3T3-L1 cells affects the expression of the mouse GLUT4 gene.

Yokomori, N., Tawata, M., & Onaya, T. (1999) · Diabetes · doi:10.2337/diabetes.48.4.685 · Cited by 101

Active Mammalian Replication Origins Are Associated with a High-Density Cluster of mCpG Dinucleotides

Rein, T., Zorbas, H., & DePamphilis, M. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.416 · Cited by 98

Effects of sodium butyrate on the synthesis and methylation of DNA in normal cells and their transformed counterparts.

de Haan, J. B., Gevers, W., & Parker, M. I. (1986) · PubMed · Cited by 95

Inheritance of an Epigenetic Mark: The CpG DNA Methyltransferase 1 Is Required for De Novo Establishment of a Complex Pattern of Non-CpG Methylation

Grandjean, V., Yaman, R., Cuzin, F., & Rassoulzadegan, M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001136 · Cited by 89

Densely Methylated DNA Islands in Mammalian Chromosomal Replication Origins

Tasheva, E. S., & Roufa, D. J. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5636 · Cited by 62

Do Maternal Methyl Supplements in Mice Affect DNA Methylation of Offspring?

Waterland, R. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.1.238 · Cited by 54

PPARGC1A mRNA levels of in vitro differentiated human skeletal muscle cells are negatively associated with the plasma oleate concentrations of the donors

Staiger, H., Stefan, N., Machicao, F. E., Fritsche, A., & Häring, H. (2005) · Diabetologia · doi:10.1007/s00125-005-0061-y · Cited by 23

Decreased expression of insulin-sensitive glucose transporter mRNA (GLUT-4) in adipose tissue of non-insulin-dependent diabetic and obese patients: Evaluation by a simplified quantitative PCR assay

Giacchetti, G., Faloia, E., Taccaliti, A., Morosini, P., Arnaldi, G., Soletti, F., Mantero, F., Accili, D., & Pirro, R. D. (1994) · Journal of Endocrinological Investigation · doi:10.1007/bf03347765 · Cited by 18

Genome-wide methylation profiles reveal quantitative views of human aging rates

Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270

Impact of obesity on male fertility, sperm function and molecular composition

Palmer, N. O., Bakos, H. W., Fullston, T., & Lane, M. (2012) · Spermatogenesis · doi:10.4161/spmg.21362 · Cited by 403

The Circadian Syndrome: is the Metabolic Syndrome and much more!

Zimmet, P., Alberti, K. G. M. M., Stern, N., Bilu, C., El‐Osta, A., Einat, H., & Kronfeld‐Schor, N. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12924 · Cited by 387

Paternal obesity is associated with IGF2hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

Soubry, A., Schildkraut, J. M., Murtha, A. P., Wang, F. M., Huang, Z., Bernal, A. J., Kurtzberg, J., Jirtle, R. L., Murphy, S. K., & Hoyo, C. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-29 · Cited by 364

The Osteological Paradox 20 Years Later: Past Perspectives, Future Directions

DeWitte, S. N., & Stojanowski, C. M. (2015) · Journal of Archaeological Research · doi:10.1007/s10814-015-9084-1 · Cited by 348

Asociation between metabolic status and the methylation level of genes involved in metabolic disorders and obesity

Castellano‐Castillo, D., Moreno‐Indias, I., César, M. J. P., Garcı́a-Alemán, J., Macías‐González, M., Tinahones, F. J., Ortuño, M. I. Q., & Cardona, F. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.356

Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond

Cheng, Z., Zheng, L., & Almeida, F. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.004 · Cited by 117

Role of genetic and environmental factors in DNA methylation of lipid metabolism

He, Z., Zhang, R., Jiang, F., Hou, W., & Hu, C. (2017) · Genes & Diseases · doi:10.1016/j.gendis.2017.11.005 · Cited by 35

Genome-Wide DNA and Histone Modification Studies in Metabolic Disease

Ling, C., & Rönn, T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800140-0.00012-1

DNA Methylation in Obesity and Associated Diseases

Crujeiras, A. B., & Díaz‐Lagares, Á. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801899-6.00016-4 · Cited by 15