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Cited by 328Liver Disease Diagnosis and TreatmentDiet and metabolism studiesDietary Effects on Health

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction

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Browning, Jeffrey D, Baker, Jonathan A, Rogers, Thomas, Davis, Jeannie, Satapati, Santhosh, Burgess, Shawn C·2011·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.110.007674PMC PMC3076656
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Abstract

Background Individuals with nonalcoholic fatty liver disease (NAFLD) have excess intrahepatic triglycerides. This is due, in part, to increased hepatic synthesis of fat from carbohydrates via lipogenesis. Although weight loss is currently recommended to treat NAFLD, little attention has been given to dietary carbohydrate restriction.Objective The aim of this study was to determine the effectiveness of 2 wk of dietary carbohydrate and calorie restriction at reducing hepatic triglycerides in subjects with NAFLD.Design Eighteen NAFLD subjects (n = 5 men and 13 women) with a mean (±SD) age of 45 ± 12 y and a body mass index (in kg/m(2)) of 35 ± 7 consumed a carbohydrate-restricted (<20 g/d) or calorie-restricted (1200-1500 kcal/d) diet for 2 wk. Hepatic triglycerides were measured before and after intervention by magnetic resonance spectroscopy.Results Mean (±SD) weight loss was similar between the groups (-4.0 ± 1.5 kg in the calorie-restricted group and -4.6 ± 1.5 kg in the carbohydrate-restricted group; P = 0.363). Liver triglycerides decreased significantly with weight loss (P < 0.001) but decreased significantly more (P = 0.008) in carbohydrate-restricted subjects (-55 ± 14%) than in calorie-restricted subjects (-28 ± 23%). Dietary fat (r = 0.643, P = 0.004), carbohydrate (r = -0.606, P = 0.008), posttreatment plasma ketones (r = 0.755, P = 0.006), and respiratory quotient (r = -0.797, P < 0.001) were related to a reduction in liver triglycerides. Plasma aspartate, but not alanine, aminotransferase decreased significantly with weight loss (P < 0.001).Conclusions Two weeks of dietary intervention (≈4.3% weight loss) reduced hepatic triglycerides by ≈42% in subjects with NAFLD; however, reductions were significantly greater with dietary carbohydrate restriction than with calorie restriction. This may have been due, in part, to enhanced hepatic and whole-body oxidation. This trial was registered at clinicaltrials.gov as NCT01262326.

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Crossref · 10.3945/ajcn.110.007674

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Metadata

Authors
Browning, J. D., Baker, J. A., Rogers, T., Davis, J., Satapati, S., & Burgess, S. C.
Affiliations
The University of Texas Southwestern Medical Center (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2011-05
Volume
93
Issue
5
Pages
1048-1052
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.110.007674
PMC
PMC3076656
OpenAlex
W2129727129
Cited by
328
References
31
Citations by year
2026: 11 · 2025: 26 · 2024: 24 · 2023: 23 · 2022: 40 · 2021: 20 · 2020: 21 · 2019: 24 · 2018: 23 · 2017: 22 · 2016: 21 · 2015: 13 · 2014: 22 · 2013: 17 · 2012: 12
FWCI
14.22
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (PL1DK081182, DK082872, U01DK082872, PL1DK081183, RL1DK081187, K23DK074396, R01DK087977, R01DK078184)
  • National Institute of Dental and Craniofacial Research (UL1DE019584)
  • National Center for Research Resources (P41RR002584, UL1RR024982, RR‐02584)
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Keywords
non-alcoholic fatty liver disease, hepatic triglycerides, carbohydrate restriction, caloric restriction, weight loss, lipogenesis, ketones, respiratory quotient, transaminases, short-term dietary intervention, dietary fat intake, obesity, liver fat reduction, hepatic steatosis
MeSH terms
Adult, Diet, Reducing, Fatty Liver, Female, Humans, Ketones, Liver, Magnetic Resonance Imaging, Male, Middle Aged, Oxygen Consumption, Triglycerides, Weight Loss, Body Mass Index, Diet, Carbohydrate-Restricted

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