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Cited by 189Vitamin D Research StudiesDiabetes, Cardiovascular Risks, and LipoproteinsNutritional Studies and Diet

The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.

Serum 25-hydroxyvitamin D concentrations are associated with prevalence of metabolic syndrome and various cardiometabolic risk factors in US children and adolescents based on assay-adjusted serum 25-hydroxyvitamin D data from NHANES 2001–2006

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Ganji, Vijay, Zhang, Xu, Shaikh, Nida, Tangpricha, Vin·2011·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.111.013516
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Abstract

Background The effect of assay drifts over time on serum 25-hydroxyvitamin D [25(OH)D] concentrations were not accounted for in previous national survey studies. Thus, previously reported associations between 25(OH)D with cardiometabolic risk factors using data from NHANES were likely over- or underestimated. Moreover, associations between serum 25(OH)D and metabolic syndrome (MetSyn), insulin resistance (IR), and inflammation are unclear in children.Objective The relation between serum 25(OH)D and cardiometabolic risk factors in US children was investigated by using updated 25(OH)D data.Design This study was based on newly updated serum 25(OH)D data, which were released by the National Center for Health Statistics in November 2010. Data from 3 cycles of NHANES (2001-2002, 2003-2004, and 2005-2006) for 5867 adolescents, aged 12-19 y, were used to study the association, by multivariate-adjusted regression, between serum 25(OH)D and prevalence of MetSyn and several cardiometabolic risk factors.Results The likelihood of having MetSyn was significantly higher in the first tertile of serum 25(OH)D than in the third tertile of 25(OH)D (odds ratio: 1.71; 95% CI: 1.11, 2.65; P < 0.01). Waist circumference (P < 0.0001), systolic blood pressure (P = 0.01), and homeostatic model assessment-insulin resistance index (P = 0.001) were inversely related and HDL cholesterol (P < 0.0001) was directly related with serum 25(OH)D. No association was observed between 25(OH)D and C-reactive protein (P = 0.18).Conclusions On the basis of assay-adjusted data, serum 25(OH)D was significantly associated with several cardiometabolic risk factors regardless of obesity. In children, given the negative outcomes associated with poor vitamin D status and MetSyn, consideration of vitamin D supplementation in reversing cardiometabolic risk factors appears to be warranted.

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Metadata

Authors
Ganji, V., Zhang, X., Shaikh, N., & Tangpricha, V.
Affiliations
Emory University (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2011-07
Volume
94
Issue
1
Pages
225-233
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.111.013516
OpenAlex
W2118926394
Cited by
189
References
59
Citations by year
2026: 2 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 11 · 2020: 13 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 13 · 2015: 12 · 2014: 9 · 2013: 17 · 2012: 30
FWCI
13.43
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
25-hydroxyvitamin D, vitamin D status, metabolic syndrome, cardiometabolic risk factors, children and adolescents, insulin resistance, waist circumference, systolic blood pressure, HDL cholesterol, C-reactive protein, inflammation, obesity, NHANES, vitamin D supplementation, vitamin D deficiency, vitamin D excess, cardiovascular disease prevention, diabetes prevention
MeSH terms
Adolescent, Adult, Cardiovascular Diseases, Child, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Health Surveys, Humans, Insulin Resistance, Cholesterol, HDL, Male, Risk Factors, Time Factors, Vitamin D, Prevalence, Metabolic Syndrome

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