The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.
Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial
Open accessAbstract
Background Sedentary behavior is a risk factor for cardiometabolic disease. Regularly interrupting sedentary behavior with activity breaks may lower this risk.Objective We compared the effects of prolonged sitting, continuous physical activity combined with prolonged sitting, and regular activity breaks on postprandial metabolism.Design Seventy adults participated in a randomized crossover study. The prolonged sitting intervention involved sitting for 9 h, the physical activity intervention involved walking for 30 min and then sitting, and the regular-activity-break intervention involved walking for 1 min 40 s every 30 min. Participants consumed a meal-replacement beverage at 60, 240, and 420 min.Results The plasma incremental area under the curve (iAUC) for insulin differed between interventions (overall P < 0.001). Regular activity breaks lowered values by 866.7 IU · L(-1) · 9 h(-1) (95% CI: 506.0, 1227.5 IU · L(-1) · 9 h(-1); P < 0.001) when compared with prolonged sitting and by 542.0 IU · L(-1) · 9 h(-1) (95% CI: 179.9, 904.2 IU · L(-1) · 9 h(-1); P = 0.003) when compared with physical activity. Plasma glucose iAUC also differed between interventions (overall P < 0.001). Regular activity breaks lowered values by 18.9 mmol · L(-1) · 9 h(-1) (95% CI: 10.0, 28.0 mmol · L(-1) · 9 h(-1); P < 0.001) when compared with prolonged sitting and by 17.4 mmol · L(-1) · 9 h(-1) (95% CI: 8.4, 26.3 mmol · L(-1) · 9 h(-1); P < 0.001) when compared with physical activity. Plasma triglyceride iAUC differed between interventions (overall P = 0.023). Physical activity lowered values by 6.3 mmol · L(-1) · 9 h(-1) (95% CI: 1.8, 10.7 mmol · L(-1) · 9 h(-1); P = 0.006) when compared with regular activity breaks.Conclusion Regular activity breaks were more effective than continuous physical activity at decreasing postprandial glycemia and insulinemia in healthy, normal-weight adults. This trial was registered with the Australian New Zealand Clinical Trials registry as ACTRN12610000953033.
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“In addition, replacing SB by LIPA also had as strong an effect as replacing it with MVPA (Table 4), as it has been observed experimentally [43–45].”
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Metadata
- Authors
- Peddie, M. C., Bone, J. L., Rehrer, N. J., Skeaff, C. M., Gray, A. R., & Perry, T. L.
- Affiliations
- University of Otago (NZ)
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 98
- Issue
- 2
- Pages
- 358-366
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2118900499
- Cited by
- 431
- References
- 36
- Citations by year
- 2026: 21 · 2025: 15 · 2024: 18 · 2023: 22 · 2022: 28 · 2021: 40 · 2020: 37 · 2019: 42 · 2018: 42 · 2017: 61 · 2016: 40 · 2015: 35 · 2014: 27 · 2013: 3
- FWCI
- 24.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- sedentary behavior, prolonged sitting, postprandial blood glucose, active breaks, walking breaks, physical activity, insulin response, plasma glucose, plasma triglycerides, cardiometabolic risk, postprandial lipemia, postprandial insulin response, postprandial glucose response, postprandial triglycerides
- MeSH terms
- Adult, Beverages, Blood Glucose, Cardiovascular Diseases, Diet, Female, Humans, Insulin, Male, New Zealand, Risk Factors, Time Factors, Triglycerides, Exercise, Body Mass Index, Walking, Cross-Over Studies, Postprandial Period, Area Under Curve, Young Adult, Sedentary Behavior
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