The DOI matches its Crossref record; 61 of the 65 references it cites were found in a registry or an index.
Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)
Open accessAbstract
Background Vitamin C (ascorbic acid) may be the most important water-soluble antioxidant in human plasma. In the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994), approximately 13% of the US population was vitamin C deficient (serum concentrations <11.4 micromol/L).Objective The aim was to determine the most current distribution of serum vitamin C concentrations in the United States and the prevalence of deficiency in selected subgroups.Design Serum concentrations of total vitamin C were measured in 7277 noninstitutionalized civilians aged > or =6 y during the cross-sectional, nationally representative NHANES 2003-2004. The prevalence of deficiency was compared with results from NHANES III.Results The overall age-adjusted mean from the square-root transformed (SM) concentration was 51.4 micromol/L (95% CI: 48.4, 54.6). The highest concentrations were found in children and older persons. Within each race-ethnic group, women had higher concentrations than did men (P < 0.05). Mean concentrations of adult smokers were one-third lower than those of nonsmokers (SM: 35.2 compared with 50.7 micromol/L and 38.6 compared with 58.0 micromol/L in men and women, respectively). The overall prevalence (+/-SE) of age-adjusted vitamin C deficiency was 7.1 +/- 0.9%. Mean vitamin C concentrations increased (P < 0.05) and the prevalence of vitamin C deficiency decreased (P < 0.01) with increasing socioeconomic status. Recent vitamin C supplement use or adequate dietary intake decreased the risk of vitamin C deficiency (P < 0.05).Conclusions In NHANES 2003-2004, vitamin C status improved, and the prevalence of vitamin C deficiency was significantly lower than that during NHANES III, but smokers and low-income persons were among those at increased risk of deficiency.
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In the citing paper
“a national survey in the United States in the years 2003–2004 reported that 7% of persons had a vitamin C plasma level below 11.4 µM [61].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [61]
In the citing paper
“The levels of vitamin C fluctuate with age. They are highest in the category of 6 to 11 years old and then gradually decrease. There is, however, an increase in the population over 60 years old in both men and women [61].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [61]
In the citing paper
“Women have, in general, higher plasma levels than men [61].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [61]
In the citing paper
“Smoking decreases the plasma level of vitamin C on an average by 25–50% [52,61,63].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [61]
In the citing paper
“There is no difference between serum and plasma [59,60,61,62,63].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [61]
In the citing paper
“In contrast, only 7.1% of the general US population are vitamin C deficient.57”
From Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia (2018) · cites this paper as [57]
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Metadata
- Authors
- Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A.
- Affiliations
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Schleicher, Rosemary L
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 90
- Issue
- 5
- Pages
- 1252-1263
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2097237102
- Cited by
- 504
- References
- 65
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 32 · 2023: 46 · 2022: 60 · 2021: 44 · 2020: 45 · 2019: 28 · 2018: 35 · 2017: 31 · 2016: 26 · 2015: 28 · 2014: 19 · 2013: 19 · 2012: 25
- FWCI
- 16.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
- Keywords
- vitamin C, scurvy, prevalence, smoking, socioeconomic status, vitamin C supplementation, dietary intake, sex differences, age differences, antioxidant status
- MeSH terms
- Adolescent, Adult, Ascorbic Acid, Ascorbic Acid Deficiency, Child, Cross-Sectional Studies, Diet, Ethnicity, Female, Humans, Interviews as Topic, Male, Nutrition Surveys, Poverty, Probability, Smoking, Socioeconomic Factors, United States, Body Mass Index, Dietary Supplements, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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