Cited by 520Vitamin C and Antioxidants ResearchAntioxidant Activity and Oxidative StressNutrition and Health Studies

The DOI matches its Crossref record; 61 of the 65 references it cites were found in a registry or an index.

Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)

Open access

Schleicher, Rosemary L, Carroll, Margaret D, Ford, Earl S, Lacher, David A·2009·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2008.27016

Open this paper in CoChat — free account

Abstract

Background Vitamin C (ascorbic acid) may be the most important water-soluble antioxidant in human plasma. In the third National Health and Nutrition Examination Survey (NHANES III, 1988-1994), approximately 13% of the US population was vitamin C deficient (serum concentrations <11.4 micromol/L).Objective The aim was to determine the most current distribution of serum vitamin C concentrations in the United States and the prevalence of deficiency in selected subgroups.Design Serum concentrations of total vitamin C were measured in 7277 noninstitutionalized civilians aged > or =6 y during the cross-sectional, nationally representative NHANES 2003-2004. The prevalence of deficiency was compared with results from NHANES III.Results The overall age-adjusted mean from the square-root transformed (SM) concentration was 51.4 micromol/L (95% CI: 48.4, 54.6). The highest concentrations were found in children and older persons. Within each race-ethnic group, women had higher concentrations than did men (P < 0.05). Mean concentrations of adult smokers were one-third lower than those of nonsmokers (SM: 35.2 compared with 50.7 micromol/L and 38.6 compared with 58.0 micromol/L in men and women, respectively). The overall prevalence (+/-SE) of age-adjusted vitamin C deficiency was 7.1 +/- 0.9%. Mean vitamin C concentrations increased (P < 0.05) and the prevalence of vitamin C deficiency decreased (P < 0.01) with increasing socioeconomic status. Recent vitamin C supplement use or adequate dietary intake decreased the risk of vitamin C deficiency (P < 0.05).Conclusions In NHANES 2003-2004, vitamin C status improved, and the prevalence of vitamin C deficiency was significantly lower than that during NHANES III, but smokers and low-income persons were among those at increased risk of deficiency.

Integrity signals

Registry

Crossref · 10.3945/ajcn.2008.27016

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Statistical principles in experimental design.
Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
Categorical Data Analysis
Agresti, A. (2002) · Wiley Series in Probability and Statistics · doi:10.1002/0471249688 · Cited by 6,746
Vitamin C as an Antioxidant: Evaluation of Its Role in Disease Prevention
Padayatty, S. J., Katz, A., Wang, Y., Eck, P., Kwon, O., Lee, J.-H., Chen, S., Corpe, C., Dutta, A., Dutta, S. K., et al. (2003) · Journal of the American College of Nutrition · doi:10.1080/07315724.2003.10719272 · Cited by 1,949
Statistical Principles in Experimental Design.
Geisser, S., & Winer, B. J. (1963) · Journal of the American Statistical Association · doi:10.2307/2283359 · Cited by 1,934
Introduction to Variance Estimation.
King, B. F., & Wolter, K. M. (1987) · Journal of the American Statistical Association · doi:10.2307/2289497 · Cited by 1,377
Fruit and vegetables, and cardiovascular disease: A review
Ness, A. R., & Powles, J. W. (1997) · International Journal of Epidemiology · doi:10.1093/ije/26.1.1 · Cited by 1,368
Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance
Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3704 · Cited by 1,325
Analysis of Health Surveys
Korn, E. L., & Graubard, B. I. (1999) · Wiley eBooks · doi:10.1002/9781118032619 · Cited by 1,081
Categorical Data Analysis
Suárez, E. L., Pérez, C. M., Nogueras, G. M., & Moreno-Gorrín, C. (2016) · CRC Press eBooks · doi:10.1201/b19547-8 · Cited by 1,049
Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study,,
Bazzano, L. A., He, J., Ogden, L. G., Loria, C. M., Vupputuri, S., Myers, L., & Whelton, P. K. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.1.93 · Cited by 1,035

Flagged first, then by citations

Show all 65 references

4 of the 65 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

1994, Anonymous. Plan and operation of the Third National Health and Nutrition Examination Survey, 1988–94. Series 1: programs and collection procedures., Vital Health Stat 1, 1, 1
Pirkle, 1996, Exposure of the US population to environmental tobacco smoke., JAMA, 275, 1233, 10.1001/jama.1996.03530400021033 · DOI
2007, Fruit and vegetable consumption among adults–United States, 2005., MMWR Morb Mortal Wkly Rep, 56, 213

Sorted by citations

Items 101–200 of 520

Plasma Vitamin C Concentrations and Cognitive Function: A Cross-Sectional Study
Travica, N., Ried, K., Sali, A., Hudson, I. L., Scholey, A. B., & Pipingas, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00072 · Cited by 49
Oral Health, Nutritional Choices, and Dental Fear and Anxiety
Beaudette, J. R., Fritz, P. C., Sullivan, P., & Ward, W. E. (2017) · Dentistry Journal · doi:10.3390/dj5010008 · Cited by 50
A Bendable Biofuel Cell-Based Fully Integrated Biomedical Nanodevice for Point-of-Care Diagnosis of Scurvy
Sun, M., Xin, T., Ran, Z., Pei, X., Ma, C., Liu, J., Cao, M., Bai, J., & Zhou, M. (2020) · ACS Sensors · doi:10.1021/acssensors.0c02335 · Cited by 48
A Randomized Study of the Effects of Additional Fruit and Nuts Consumption on Hepatic Fat Content, Cardiovascular Risk Factors and Basal Metabolic Rate
Agebratt, C., Ström, E., Romu, T., Dahlqvist-Leinhard, O., Borga, M., Leandersson, P., & Nyström, F. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0147149 · Cited by 47
Magnetic resonance imaging appearance of scurvy with gelatinous bone marrow transformation
Brennan, C. M., Atkins, K. A., Druzgal, C. H., & Gaskin, C. M. (2012) · Skeletal Radiology · doi:10.1007/s00256-011-1350-9 · Cited by 46
Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection
Patterson, T., Isales, C. M., & Fulzele, S. (2021) · Aging and Disease · doi:10.14336/ad.2020.0918 · Cited by 44
Curcumin-functionalized nanocomposite AgNPs/SDS/MWCNTs for electrocatalytic simultaneous determination of dopamine, uric acid, and guanine in co-existence of ascorbic acid by glassy carbon electrode
Haghnegahdar, N., Tarighat, M. A., & Dastan, D. (2021) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-021-05282-1 · Cited by 44
Challenges and Lessons Learned in Generating and Interpreting NHANES Nutritional Biomarker Data
Pfeiffer, C. M., Lacher, D. A., Schleicher, R. L., Johnson, C. L., & Yetley, E. A. D. (2017) · Advances in Nutrition · doi:10.3945/an.116.014076 · Cited by 44
Self-citation
Vitamin C promotes decitabine or azacytidine induced DNA hydroxymethylation and subsequent reactivation of the epigenetically silenced tumour suppressor CDKN1A in colon cancer cells
Gerecke, C., Schumacher, F., Edlich, A., Wetzel, A., Yealland, G., Neubert, L. K., Scholtka, B., Homann, T., & Kleuser, B. (2018) · Oncotarget · doi:10.18632/oncotarget.25999 · Cited by 46
The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free mass
Jungert, A., & Neuhäuser‐Berthold, M. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515000240 · Cited by 42
The impact of nutrient-rich food choices on agricultural water-use efficiency
Damerau, K., Waha, K., & Herrero, M. (2019) · Nature Sustainability · doi:10.1038/s41893-019-0242-1 · Cited by 42
Engineering Elevated Vitamin C in Plants to Improve their Nutritional Content, Growth, and Tolerance to Abiotic Stress
Lisko, K. A., Aboobucker, S. I., Torres, R., & Lorence, A. (2014) · Springer eBooks · doi:10.1007/978-3-319-04045-5_6 · Cited by 42
Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the European Prospective Investigation into Cancer-Norfolk
McCall, S. J., Clark, A. B., Luben, R. N., Wareham, N. J., Khaw, K.-T., & Myint, P. K. (2019) · Nutrients · doi:10.3390/nu11071552 · Cited by 41
Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding
Xing, Y., Zhao, B., Yin, L., Guo, M., Shi, H., Zhu, Z., Zhang, L., He, J., Ling, Y., Gao, M., et al. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.113927 · Cited by 41
Advances in Ascorbic Acid (Vitamin C) Manufacturing: Green Extraction Techniques from Natural Sources
Susa, F., & Pisano, R. (2023) · Processes · doi:10.3390/pr11113167 · Cited by 41
Vitamin C status of Canadian adults: Findings from the 2012/2013 Canadian Health Measures Survey.
Langlois, K. A., Cooper, M., & Colapinto, C. K. (2016) · PubMed · Cited by 41
The risk for scurvy in children with neurodevelopmental disorders
Kothari, P., Tate, A. R., Adewumi, A. O., Kinlin, L. M., & Ritwik, P. (2020) · Special Care in Dentistry · doi:10.1111/scd.12459 · Cited by 40
The epidemiology, impact, and diagnosis of micronutrient nutritional dermatoses part 1: Zinc, selenium, copper, vitamin A, and vitamin C
Nosewicz, J., Spaccarelli, N., Roberts, K. M., Hart, P. A., Kaffenberger, J. A., Trinidad, J. C., & Kaffenberger, B. H. (2021) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2021.07.079 · Cited by 40
Effect of Atorvastatin, Vitamin E and C on Nonalcoholic Fatty Liver Disease: Is the Combination Required?
Arendt, B. M., & Allard, J. P. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.310 · Cited by 39
Marginal Ascorbate Status (Hypovitaminosis C) Results in an Attenuated Response to Vitamin C Supplementation
Carr, A. C., Pullar, J. M., Bozonet, S. M., & Vissers, M. C. M. (2016) · Nutrients · doi:10.3390/nu8060341 · Cited by 40
Total Carotenoids and l-Ascorbic Acid Content in 60 Varieties of Potato (Solanum tuberosum L.) Grown in Ireland
Valcárcel, J., Reilly, K., Gaffney, M. T., & O’Brien, N. M. (2014) · Potato Research · doi:10.1007/s11540-014-9270-4 · Cited by 38
Quercetin bioavailability is associated with inadequate plasma vitamin C status and greater plasma endotoxin in adults
Guo, Y. C., Mah, E., & Bruno, R. S. (2014) · Nutrition · doi:10.1016/j.nut.2014.03.032 · Cited by 37
Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo−/− mice
Aumailley, L., Warren, A., Garand, C., Dubois, M. J., Paquet, É. R., Couteur, D. G. L., Marette, A., Cogger, V. C., & Lebel, M. (2016) · Aging · doi:10.18632/aging.100902 · Cited by 38
Urban foraging for food security and sovereignty: quantifying edible forest yield in Syracuse, New York using four common fruit- and nut-producing street tree species
Bunge, A., Diemont, S. A. W., Bunge, J. A., & Harris, S. (2019) · Journal of Urban Ecology · doi:10.1093/jue/juy028 · Cited by 37
Insufficient Vitamin C Levels among Adults in the United States: Results from the NHANES Surveys, 2003–2006
Crook, J., Horgas, A. L., Yoon, S. L., Grundmann, O., & Johnson‐Mallard, V. (2021) · Nutrients · doi:10.3390/nu13113910 · Cited by 37
Massive doses of vitamin C and the virus diseases
KLENNER, F. R. (1951) · PubMed · doi:10.5281/zenodo.10932887 · Cited by 37
Vitamin C in combination with inhibition of mutant IDH1 synergistically activates TET enzymes and epigenetically modulates gene silencing in colon cancer cells
Gerecke, C., Schumacher, F., Berndzen, A., Homann, T., & Kleuser, B. (2019) · Epigenetics · doi:10.1080/15592294.2019.1666652 · Cited by 36
Vitamin C supplementation reduces the odds of developing a common cold in Republic of Korea Army recruits: randomised controlled trial
Kim, T. K., Lim, H., & Byun, J. S. (2020) · BMJ Military Health · doi:10.1136/bmjmilitary-2019-001384 · Cited by 39
MicroRNAs-141 and 200a regulate the SVCT2 transporter in bone marrow stromal cells
Sangani, R., Periyasamy‐Thandavan, S., Kolhe, R. B., Bhattacharyya, M. H., Chutkan, N. B., Hunter, M., Isales, C. M., Hamrick, M. W., Hill, W., & Fulzele, S. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.01.007 · Cited by 36
Trends in Vitamin C consumption in the United States: 1999-2018
Brauchla, M., Dekker, M. J., & Rehm, C. D. (2021) · Nutrients · doi:10.3390/nu13020420 · Cited by 35
Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease
Gordon, B. L., Galati, J. S., Yang, S., Longman, R., Lukin, D. J., Scherl, E., & Battat, R. J. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i33.4834 · Cited by 35
Effects of vitamins C and D in type 2 diabetes mellitus
Girgis, C. M., Christie‐David, D., & Gunton, J. E. (2015) · Nutrition and Dietary Supplements · doi:10.2147/nds.s52022 · Cited by 36
Simultaneous voltammetric detection of anti-depressant drug, sertraline HCl and paracetamol in biological fluid at CNT-cesium modified electrode in micellar media
Atty, S. A., Ibrahim, A. H., Ibrahim, H., Abdelzaher, A. M., Abdel‐Raoof, A. M., & Fouad, F. A. (2020) · Microchemical Journal · doi:10.1016/j.microc.2020.105524 · Cited by 35
Serum antioxidant vitamins and respiratory morbidity and mortality: a pooled analysis
Salo, P. M., Mendy, A., Wilkerson, J., Molsberry, S. A., Feinstein, L., London, S. J., Fessler, M. B., Thorne, P. S., & Zeldin, D. C. (2022) · Respiratory Research · doi:10.1186/s12931-022-02059-w · Cited by 35
Determination of plasma and leukocyte vitamin C concentrations in a randomized, double-blind, placebo-controlled trial with Ester-C(®)
Mitmesser, S. H., Ye, Q., Evans, M., & Combs, M. (2016) · SpringerPlus · doi:10.1186/s40064-016-2605-7 · Cited by 34
Can vitamins improve periodontal wound healing/regeneration?
El‐Sayed, K. M. F., Cosgarea, R., Sculean, A., & Dörfer, C. E. (2023) · Periodontology 2000 · doi:10.1111/prd.12513 · Cited by 34
Pharmacokinetics of vitamin dosage forms: A complete overview
Sugandhi, V. V., Pangeni, R., Vora, L. K., Poudel, S., Nangare, S., Jagwani, S., Gadhave, D. G., Qin, C., Pandya, A., Shah, P., et al. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3787 · Cited by 35
Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1
Block, G., Shaikh, N., Jensen, C. D., Volberg, V., & Holland, N. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.011460 · Cited by 34
Genetic Variation in Human Vitamin C Transporter Genes in Common Complex Diseases
Shaghaghi, M. A., Kloss, O., & Eck, P. (2016) · Advances in Nutrition · doi:10.3945/an.115.009225 · Cited by 38
Emerging Evidence on Neutrophil Motility Supporting Its Usefulness to Define Vitamin C Intake Requirements
Elste, V., Troesch, B., Eggersdorfer, M. L., & Weber, P. (2017) · Nutrients · doi:10.3390/nu9050503 · Cited by 34
Vitamin C deficiency in an Australian cohort of metropolitan surgical patients
Ravindran, P., Wiltshire, S., Das, K., & Wilson, R. B. (2018) · Pathology · doi:10.1016/j.pathol.2018.07.004 · Cited by 33
Correlation of D-xylose with severity and morbidity-related factors of COVID-19 and possible therapeutic use of D-xylose and antibiotics for COVID-19
Cheudjeu, A. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118335 · Cited by 33
Epigenetic remodeling by vitamin C potentiates plasma cell differentiation
Chen, H.-Y., Almonte-Loya, A., Lay, F.-Y., Hsu, M., Johnson, E. C., González‐Avalos, E., Yin, J., Bruno, R. S., Ma, Q., Ghoneim, H. E., et al. (2022) · eLife · doi:10.7554/elife.73754 · Cited by 37
Titanium(IV) and Vitamin C: Aqueous Complexes of a Bioactive Form of Ti(IV)
Buettner, K. M., Collins, J. M., & Valentine, A. M. (2012) · Inorganic Chemistry · doi:10.1021/ic301545m · Cited by 33
Mitochondrial Uptake and Accumulation of Vitamin C: What Can We Learn from Cell Culture Studies?
Cantoni, O., Guidarelli, A., & Fiorani, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7253 · Cited by 33
Mouse Homolog of the Human TP53 R337H Mutation Reveals Its Role in Tumorigenesis
Park, J., Li, J., Starost, M. F., Liu, C., Zhuang, J., Chen, J., Achatz, M. I., Kang, J., Wang, P., Savage, S. A., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0016 · Cited by 32
Vitamins as Possible Cancer Biomarkers: Significance and Limitations
Venturelli, S., Leischner, C., Helling, T., Burkard, M., & Marongiu, L. (2021) · Nutrients · doi:10.3390/nu13113914 · Cited by 33
The Effects of Supplementation with a Vitamin and Mineral Complex with Guaraná Prior to Fasted Exercise on Affect, Exertion, Cognitive Performance, and Substrate Metabolism: A Randomized Controlled Trial
Veasey, R. C., Haskell‐Ramsay, C. F., Kennedy, D. O., Wishart, K., Maggini, S., Fuchs, C. J., & Stevenson, E. (2015) · Nutrients · doi:10.3390/nu7085272 · Cited by 37
Scurvy as a mimicker of osteomyelitis in a child with autism spectrum disorder
Kinlin, L. M., Blanchard, A. C., Silver, S., & Morris, S. K. (2018) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2018.02.002 · Cited by 32
Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells
Wohlrab, C., Kuiper, C., Vissers, M. C. M., Phillips, E., Robinson, B. A., & Dachs, G. U. (2019) · Hypoxia · doi:10.2147/hp.s201643 · Cited by 32
Vitamin C and A1c Relationship in the National Health and Nutrition Examination Survey (NHANES) 2003–2006
Kositsawat, J., & Freeman, V. L. (2011) · Journal of the American College of Nutrition · doi:10.1080/07315724.2011.10719993 · Cited by 32
Genetic Determinants of Dietary Antioxidant Status
Costa, L. A. D., García‐Bailo, B., Badawi, A. F., & El‐Sohemy, A. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-398397-8.00008-3 · Cited by 30
Vitamin C fortification: need and recent trends in encapsulation technologies
Maurya, V. K., Shakya, A., McClements, D. J., Srinivasan, R., Bashir, K., Ramesh, T., Lee, J., & Sathiyamoorthi, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1229243 · Cited by 37
Vitamin C Deficiency in Inflammatory Bowel Disease: The Forgotten Micronutrient
Dunleavy, K. A., Ungaro, R. C., Manning, L., Gold, S. L., Novak, J. D., & Colombel, J. (2021) · Crohn s & Colitis 360 · doi:10.1093/crocol/otab009 · Cited by 29
Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight
Carr, A. C., Spencer, E. S., Heenan, H. F., Lunt, H., Vollebregt, M. J., & Prickett, T. C. R. (2022) · Antioxidants · doi:10.3390/antiox11020245 · Cited by 29
The Contribution of Plasma and Brain Vitamin C on Age and Gender-Related Cognitive Differences: A Mini-Review of the Literature
Travica, N., Ried, K., Hudson, I. L., Sali, A., Scholey, A. B., & Pipingas, A. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00047 · Cited by 31
Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports
Hemilä, H., & de Man, A. (2024) · BMC Pulmonary Medicine · doi:10.1186/s12890-024-02941-x · Cited by 29
The Dietary Fructose:Vitamin C Intake Ratio Is Associated with Hyperuricemia in African-American Adults
Zheng, Z., Harman, J. L., Coresh, J., Köttgen, A., McAdams‐DeMarco, M., Correa, A., Young, B. A., Katz, R., & Rebholz, C. M. (2018) · Journal of Nutrition · doi:10.1093/jn/nxx054 · Cited by 27
Dietary intake and micronutrient deficiency in children with cancer
Morrell, M. B. G., Baker, R. A., Johnson, A., Santizo, R. O., Liu, D., & Moody, K. M. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27895 · Cited by 27
Vitamin C Status of US Adults Assessed as Part of the National Health and Nutrition Examination Survey Remained Unchanged between 2003–2006 and 2017–2018
Powers, C. D., Sternberg, M., Patel, S. B., Pfeiffer, C. M., Storandt, R., & Schleicher, R. L. (2023) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfac093 · Cited by 27
Self-citation
Does Aging Have an Impact on Vitamin C Status and Requirements? A Scoping Review of Comparative Studies of Aging and Institutionalisation
Carr, A. C., & Zawari, M. (2023) · Nutrients · doi:10.3390/nu15040915 · Cited by 27
Neuropsychiatric Scurvy
Brown, T. M. (2014) · Psychosomatics · doi:10.1016/j.psym.2014.05.010 · Cited by 27
Bleeding tendency and ascorbic acid requirements: systematic review and meta-analysis of clinical trials
Hujoel, P. P., Kato, T., Hujoel, I. A., & Hujoel, M. L. A. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuaa115 · Cited by 27
Vitamin C – a scoping review for Nordic Nutrition Recommendations 2023
Lykkesfeldt, J., & Carr, A. C. (2023) · Food & Nutrition Research · doi:10.29219/fnr.v67.10300 · Cited by 25
Prolonged maternal vitamin C deficiency overrides preferential fetal ascorbate transport but does not influence perinatal survival in guinea pigs
Schjoldager, J. G., Tveden‐Nyborg, P., & Lykkesfeldt, J. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000913 · Cited by 25
Molecular mechanism(s) involved in differential expression of vitamin C transporters along the intestinal tract
Subramanian, V. S., Srinivasan, P., Wildman, A., Marchant, J. S., & Said, H. M. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00369.2016 · Cited by 25
High doses of vitamin C plus E reduce strength training-induced improvements in areal bone mineral density in elderly men
Stunes, A. K., Syversen, U., Berntsen, S., Paulsen, G., Stea, T. H., Hetlelid, K. J., Lohne‐Seiler, H., Mosti, M. P., Bjørnsen, T., Raastad, T., et al. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3588-y · Cited by 25
A Pilot Study Examining Vitamin C Levels in Periodontal Patients
Munday, M.-R., Rodricks, R., Fitzpatrick, M., Flood, V. M., & Gunton, J. E. (2020) · Nutrients · doi:10.3390/nu12082255 · Cited by 24
Vitamin C levels amongst initial survivors of out of hospital cardiac arrest
Gardner, R. M., Liu, X., Wang, Y., Cole, A. C., Heydrick, S. J., Donnino, M. W., & Moskowitz, A. L. (2020) · Resuscitation · doi:10.1016/j.resuscitation.2020.09.005 · Cited by 25
Evidence of a Positive Link between Consumption and Supplementation of Ascorbic Acid and Bone Mineral Density
Rondanelli, M., Peroni, G., Fossari, F., Vecchio, V., Faliva, M. A., Naso, M., Perna, S., Paolo, E. D., Riva, A., Petrangolini, G., et al. (2021) · Nutrients · doi:10.3390/nu13031012 · Cited by 24
Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists
Chapple, I., Matthews, J. B., Wright, H. J., Scott, A. E., Griffiths, H. R., & Grant, M. M. (2012) · Innate Immunity · doi:10.1177/1753425912455207 · Cited by 24
Scurvy: An Unexpected Nutritional Complication in an Adolescent Female With Anorexia Nervosa
Roy-Lavallee, J., Bahrani, B., Weinstein, M., & Katzman, D. K. (2020) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2020.02.022 · Cited by 23
A New Method for Calculating Vitamin C Content and Determining Appropriate Vitamin C Levels in FoodsPreprint
Forouzesh, A., Forouzesh, F., Foroushani, S. S., & Forouzesh, A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4133651 · Cited by 23
Una mirada actual de la vitamina C en salud y enfermedad
Villagrán, M., Muñoz-Roa, M., Díaz, F., Troncoso-Pantoja, C., Celis-Morales, C. A., & Mardones, L. (2019) · Revista chilena de nutrición · doi:10.4067/s0717-75182019000600800 · Cited by 22
Vitamin C, Antioxidant Status, and Cardiovascular Aging
Ashor, A. W., Siervo, M., & Mathers, J. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00043-1 · Cited by 23
Illuminating tomato fruit enhances fruit vitamin C content
Ntagkas, N., Min, Q., Woltering, E. J., Labrie, C. W., Nicole, C. C. S., & Marcelis, L. F. M. (2016) · Acta Horticulturae · doi:10.17660/actahortic.2016.1134.46 · Cited by 21
Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People
Gana, W., Luca, A. D., Debacq, C., Poitau, F., Poupin, P., Aïdoud, A., & Fougère, B. (2021) · Nutrients · doi:10.3390/nu13093163 · Cited by 26
Vitamin C improves gut Bifidobacteria in humans
Hazan, S., Davé, S., Papoutsis, A. J., Deshpande, N., Howell, M., & Martin, L. M. A. (2022) · Future Microbiology · doi:10.2217/fmb-2022-0209 · Cited by 21
Micronutrients in hair loss
Ruiz-Tagle, S. A., Figueira, M. M. D. S. A., Vial, V., Espinoza-Benavides, L., & Maria, M. (2018) · Our Dermatology Online · doi:10.7241/ourd.20183.25 · Cited by 21
Scurvy is Back
Callus, C. A., Vella, S., & Ferry, P. (2018) · Nutrition and Metabolic Insights · doi:10.1177/1178638818809097 · Cited by 21
Vitamin C Deficiency in the Young Brain—Findings from Experimental Animal Models
Tveden‐Nyborg, P. (2021) · Nutrients · doi:10.3390/nu13051685 · Cited by 25
Intake of Vitamin E and C in Women of Reproductive Age: Results from the Latin American Study of Nutrition and Health (ELANS)
Busso, D., David, A., Peñailillo, R. S., Echeverría, G., Rigotti, A., Kovalskys, I., Gómez, G., Cortés, L. Y., García, M. C. Y., Pareja, R. G., et al. (2021) · Nutrients · doi:10.3390/nu13061954 · Cited by 23
Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis
Chang, G. R., Lin, W., Fan, H., Tu, M., Liu, Y.-H., Yen, C., Cidem, A., Chen, W., & Chen, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113859 · Cited by 20
Scurvy: a rare case in an adult
Joshi, R., French, C. N., Fanburg–Smith, J. C., Helm, K. F., & Flemming, D. J. (2018) · Skeletal Radiology · doi:10.1007/s00256-018-3069-3 · Cited by 20
Ascorbic Acid Route to the Endoplasmic Reticulum: Function and Role in Disease
Pozzer, D., Invernizzi, R. W., Blaauw, B., Cantoni, O., & Zito, E. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7912 · Cited by 20
Massive doses of vitamin C and the virus diseases
Klenner, F. R. (1951) · doi:10.5281/zenodo.14495005 · Cited by 20
Gender Differences in Plasma Vitamin C Concentrations and Cognitive Function: A Pilot Cross-Sectional Study in Healthy Adults
Travica, N., Ried, K., Hudson, I. L., Sali, A., Scholey, A. B., & Pipingas, A. (2020) · Current Developments in Nutrition · doi:10.1093/cdn/nzaa038 · Cited by 19
Vitamin C Differentially Impacts the Serum Proteome Profile in Female and Male Mice
Aumailley, L., Bourassa, S., Gotti, C., Droit, A., & Lebel, M. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00542 · Cited by 20
When the limp has a dietary cause: A retrospective study on scurvy in a tertiary Italian pediatric hospital
Masci, D., Rubino, C., Basile, M., Indolfi, G., & Trapani, S. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.981908 · Cited by 19
The association between vitamin C dietary intake and its serum levels with anthropometric indices: A systematic review and meta-analysis
Mazaheri‐Tehrani, S., Yazdi, M., Heidari‐Beni, M., Yazdani, Z., & Kelishadi, R. (2023) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2023.101733 · Cited by 20
Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells
Chothe, P. P., Chutkan, N. B., Sangani, R., Wenger, K., Prasad, P. D., Thangaraju, M., Hamrick, M. W., Isales, C. M., Ganapathy, V., & Fulzele, S. (2013) · The Spine Journal · doi:10.1016/j.spinee.2013.01.022 · Cited by 20
Vitamin C supplementation for prevention and treatment of pneumonia
Padhani, Z. A., Moazzam, Z., Ashraf, A., Bilal, H., Salam, R. A., Das, J. K., & Bhutta, Z. A. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013134.pub3 · Cited by 19
Vitamin C: working on the x-axis
Levine, M., & Eck, P. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28687 · Cited by 19
Cobinamide is a strong and versatile antioxidant that overcomes oxidative stress in cells, flies, and diabetic mice
Chang, S. C., Tat, J., China, S. P., Kalyanaraman, H., Zhuang, S., Chan, A., Lai, C., Radić, Z., Abdel‐Rahman, E. A., Casteel, D. E., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac191 · Cited by 19
Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension
Gayen, S. K., Abdelrahman, A. A., Preston, I. R., Petit, R. D., & Hill, N. S. (2020) · CHEST Journal · doi:10.1016/j.chest.2019.06.043 · Cited by 18
Vitamin C deficiency mimicking inflammatory bone disease of the hand
Liebling, E. J., Sze, R. W., & Behrens, E. M. (2020) · Pediatric Rheumatology · doi:10.1186/s12969-020-00439-4 · Cited by 18
Skin manifestations of nutritional deficiency disease in children: modern day contexts
Lee, L. W., & Yan, A. C. (2012) · International Journal of Dermatology · doi:10.1111/j.1365-4632.2012.05646.x · Cited by 18
A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma
Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S., & Yamada, K. (2016) · RSC Advances · doi:10.1039/c6ra07693a · Cited by 18
Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly
Lane, D. J. R., Jansson, P. J., & Richardson, D. R. (2016) · Aging · doi:10.18632/aging.100966 · Cited by 18
The Total Nutrient Index is a Useful Measure for Assessing Total Micronutrient Exposures Among US Adults
Cowan, A., Bailey, R. L., Jun, S., Dodd, K. W., Gahche, J. J., Eicher‐Miller, H. A., Guenther, P. M., Dwyer, J. T., Potischman, N. A., Bhadra, A., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab428 · Cited by 18

Authors: Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A.
Affiliations: Centers for Disease Control and Prevention (US)
Corresponding author: Schleicher, Rosemary L
ORCID: Schleicher, Rosemary L
Carroll, Margaret D
Lacher, David A
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2009-11
Volume: 90
Issue: 5
Pages: 1252-1263
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2008.27016
OpenAlex: W2097237102
Cited by: 504
References: 65
Citations by year: 2026: 12 · 2025: 25 · 2024: 32 · 2023: 46 · 2022: 60 · 2021: 44 · 2020: 45 · 2019: 28 · 2018: 35 · 2017: 31 · 2016: 26 · 2015: 28 · 2014: 19 · 2013: 19 · 2012: 25
FWCI: 16.46
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4862 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
Keywords: vitamin C, scurvy, prevalence, smoking, socioeconomic status, vitamin C supplementation, dietary intake, sex differences, age differences, antioxidant status
MeSH terms: Adolescent, Adult, Ascorbic Acid, Ascorbic Acid Deficiency, Child, Cross-Sectional Studies, Diet, Ethnicity, Female, Humans, Interviews as Topic, Male, Nutrition Surveys, Poverty, Probability, Smoking, Socioeconomic Factors, United States, Body Mass Index, Dietary Supplements, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES)

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks