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Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
Open accessAbstract
Background Caloric restriction leads to retardation of the aging processes and to longer life in many organisms. This effect of caloric restriction can be mimicked by resveratrol, a natural plant product present in grapes and red wine, which is known as a potent activator of sirtuin 1 [silent mating type information regulation 2 homolog 1 (Sirt1)].Objectives One main effect of caloric restriction in mammals is a reduction of body fat from white adipose tissue. We sought to identify the effects of resveratrol on fat cell biology and to elucidate whether Sirt1 is involved in resveratrol-mediated changes.Design Human Simpson-Golabi-Behmel syndrome preadipocytes and adipocytes were used to study proliferation, adipogenic differentiation, glucose uptake, de novo lipogenesis, and adipokine secretion. Sirt1-deficient human preadipocytes were generated by using a lentiviral small hairpin RNA system to study the role of Sirt1 in resveratrol-mediated changes.Results Resveratrol inhibited preadipocyte proliferation and adipogenic differentiation in a Sirt1-dependent manner. In human adipocytes, resveratrol stimulated basal and insulin-stimulated glucose uptake. De novo lipogenesis was inhibited in parallel with a down-regulation of lipogenic gene expression. Furthermore, resveratrol down-regulated the expression and secretion of interleukin-6 and interleukin-8. Sirt1 was only partially responsible for the regulation of resveratrol-mediated changes in adipokine secretion.Conclusions Taken together, our data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. Thus, our findings open up the new perspective that resveratrol-induced intracellular pathways could be a target for prevention or treatment of obesity-associated endocrine and metabolic adverse effects.
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“In addition, the polyphenol resveratrol was able to inhibit adipocyte proliferation [48,49].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [49]
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Metadata
- Authors
- Fischer-Posovszky, P., Kukulus, V., Tews, D., Unterkircher, T., Debatin, K.-M., Fulda, S., & Wabitsch, M.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Wabitsch, Martin
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 92
- Issue
- 1
- Pages
- 5-15
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2120061094
- Cited by
- 195
- References
- 67
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 11 · 2016: 20 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 26
- FWCI
- 9.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- resveratrol, SIRT1, adipocytes, adipocyte proliferation, adipogenesis, glucose uptake, de novo lipogenesis, adipokine secretion, interleukin-6, interleukin-8, caloric restriction, obesity, white adipose tissue, sirtuin activation
- MeSH terms
- Resveratrol, Adipose Tissue, Anti-Inflammatory Agents, Non-Steroidal, Cell Differentiation, Cell Division, DNA Replication, Glucose, Humans, RNA, Stilbenes, Thymidine, Cytokines, Adipocytes, DNA Primers, Codon, Nonsense, Reverse Transcriptase Polymerase Chain Reaction, Vitis, Caloric Restriction, Inverted Repeat Sequences, Sirtuin 1
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