Cited by 195Sirtuins and Resveratrol in MedicineAdipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

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Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

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Fischer-Posovszky, Pamela, Kukulus, Vera, Tews, Daniel, Unterkircher, Thomas, Debatin, Klaus-Michael, Fulda, Simone, Wabitsch, Martin·2010·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2009.28435

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Abstract

Background Caloric restriction leads to retardation of the aging processes and to longer life in many organisms. This effect of caloric restriction can be mimicked by resveratrol, a natural plant product present in grapes and red wine, which is known as a potent activator of sirtuin 1 [silent mating type information regulation 2 homolog 1 (Sirt1)].Objectives One main effect of caloric restriction in mammals is a reduction of body fat from white adipose tissue. We sought to identify the effects of resveratrol on fat cell biology and to elucidate whether Sirt1 is involved in resveratrol-mediated changes.Design Human Simpson-Golabi-Behmel syndrome preadipocytes and adipocytes were used to study proliferation, adipogenic differentiation, glucose uptake, de novo lipogenesis, and adipokine secretion. Sirt1-deficient human preadipocytes were generated by using a lentiviral small hairpin RNA system to study the role of Sirt1 in resveratrol-mediated changes.Results Resveratrol inhibited preadipocyte proliferation and adipogenic differentiation in a Sirt1-dependent manner. In human adipocytes, resveratrol stimulated basal and insulin-stimulated glucose uptake. De novo lipogenesis was inhibited in parallel with a down-regulation of lipogenic gene expression. Furthermore, resveratrol down-regulated the expression and secretion of interleukin-6 and interleukin-8. Sirt1 was only partially responsible for the regulation of resveratrol-mediated changes in adipokine secretion.Conclusions Taken together, our data suggest that resveratrol influences adipose tissue mass and function in a way that may positively interfere with the development of obesity-related comorbidities. Thus, our findings open up the new perspective that resveratrol-induced intracellular pathways could be a target for prevention or treatment of obesity-associated endocrine and metabolic adverse effects.

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Authors: Fischer-Posovszky, P., Kukulus, V., Tews, D., Unterkircher, T., Debatin, K.-M., Fulda, S., & Wabitsch, M.
Affiliations: Universität Ulm (DE)
Corresponding author: Wabitsch, Martin
ORCID: Tews, Daniel
Debatin, Klaus-Michael
Fulda, Simone
Wabitsch, Martin
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2010-07
Volume: 92
Issue: 1
Pages: 5-15
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2009.28435
OpenAlex: W2120061094
Cited by: 195
References: 67
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 7 · 2018: 15 · 2017: 11 · 2016: 20 · 2015: 14 · 2014: 12 · 2013: 17 · 2012: 26
FWCI: 9.32
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4617 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: resveratrol, SIRT1, adipocytes, adipocyte proliferation, adipogenesis, glucose uptake, de novo lipogenesis, adipokine secretion, interleukin-6, interleukin-8, caloric restriction, obesity, white adipose tissue, sirtuin activation
MeSH terms: Resveratrol, Adipose Tissue, Anti-Inflammatory Agents, Non-Steroidal, Cell Differentiation, Cell Division, DNA Replication, Glucose, Humans, RNA, Stilbenes, Thymidine, Cytokines, Adipocytes, DNA Primers, Codon, Nonsense, Reverse Transcriptase Polymerase Chain Reaction, Vitis, Caloric Restriction, Inverted Repeat Sequences, Sirtuin 1

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Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

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