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Cited by 368Thermoregulation and physiological responsesClinical Laboratory Practices and Quality ControlElectrolyte and hormonal disorders

The DOI matches its Crossref record; 59 of the 62 references it cites were found in a registry or an index.

Biological variation and diagnostic accuracy of dehydration assessment markers

Open access
Cheuvront, Samuel N, Ely, Brett R, Kenefick, Robert W, Sawka, Michael N·2010·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.2010.29490
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Abstract

Background Well-recognized markers for static (one time) or dynamic (monitoring over time) dehydration assessment have not been rigorously tested for their usefulness in clinical, military, and sports medicine communities. Objective This study evaluated the components of biological variation and the accuracy of potential markers in plasma, urine, saliva, and body mass (B(m)) for static and dynamic dehydration assessment. Design We studied 18 healthy volunteers (13 men and 5 women) while carefully controlling hydration and numerous preanalytic factors. Biological variation was determined over 3 consecutive days by using published methods. Atypical values based on statistical deviations from a homeostatic set point were examined. Measured deviations in body fluid were produced by using a separate, prospective dehydration experiment and evaluated by receiver operating characteristic (ROC) analysis to quantify diagnostic accuracy. Results All dehydration markers displayed substantial individuality and one-half of the dehydration markers displayed marked heterogeneity of intraindividual variation. Decision levels for all dehydration markers were within one SD of the ROC criterion values, and most levels were nearly identical to the prospective group means after volunteers were dehydrated by 1.8-7.0% of B(m). However, only plasma osmolality (P(osm)) showed statistical promise for use in the static dehydration assessment. A diagnostic decision level of 301 plusmn 5 mmol/kg was propo…

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Research works printed but not linked: 2

  1. Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academies Press, 2005:73–185.
  2. Institute of Medicine. Hydration status monitoring. In: Monitoring metabolic status: predicting decrements in physiological and cognitive performance. Washington, DC: National Academies Press, 2004:270–80.

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Metadata

Authors
Cheuvront, S. N., Ely, B. R., Kenefick, R. W., & Sawka, M. N.
Affiliations
U.S. Army Research Institute of Environmental Medicine (US)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2010-09
Volume
92
Issue
3
Pages
565-573
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.2010.29490
OpenAlex
W1997497052
Cited by
367
References
62
Citations by year
2026: 12 · 2025: 20 · 2024: 26 · 2023: 21 · 2022: 18 · 2021: 29 · 2020: 28 · 2019: 34 · 2018: 26 · 2017: 20 · 2016: 29 · 2015: 28 · 2014: 20 · 2013: 21 · 2012: 23
FWCI
11.91
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords
dehydration assessment, biological variation, plasma osmolality, urine specific gravity, body mass, reference change value, diagnostic accuracy, within-person variability, fluid balance, military medicine, sports medicine
MeSH terms
Adult, Body Weight, Dehydration, Female, Humans, Male, Osmolar Concentration, Prospective Studies, Reference Values, ROC Curve, Saliva, Specific Gravity, Biomarkers, Young Adult

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