Cited by 368Thermoregulation and physiological responsesClinical Laboratory Practices and Quality ControlElectrolyte and hormonal disorders

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Biological variation and diagnostic accuracy of dehydration assessment markers

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Cheuvront, Samuel N, Ely, Brett R, Kenefick, Robert W, Sawka, Michael N·2010·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.2010.29490

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Abstract

Background Well-recognized markers for static (one time) or dynamic (monitoring over time) dehydration assessment have not been rigorously tested for their usefulness in clinical, military, and sports medicine communities. Objective This study evaluated the components of biological variation and the accuracy of potential markers in plasma, urine, saliva, and body mass (B(m)) for static and dynamic dehydration assessment. Design We studied 18 healthy volunteers (13 men and 5 women) while carefully controlling hydration and numerous preanalytic factors. Biological variation was determined over 3 consecutive days by using published methods. Atypical values based on statistical deviations from a homeostatic set point were examined. Measured deviations in body fluid were produced by using a separate, prospective dehydration experiment and evaluated by receiver operating characteristic (ROC) analysis to quantify diagnostic accuracy. Results All dehydration markers displayed substantial individuality and one-half of the dehydration markers displayed marked heterogeneity of intraindividual variation. Decision levels for all dehydration markers were within one SD of the ROC criterion values, and most levels were nearly identical to the prospective group means after volunteers were dehydrated by 1.8-7.0% of B(m). However, only plasma osmolality (P(osm)) showed statistical promise for use in the static dehydration assessment. A diagnostic decision level of 301 plusmn 5 mmol/kg was propo…

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Authors: Cheuvront, S. N., Ely, B. R., Kenefick, R. W., & Sawka, M. N.
Affiliations: U.S. Army Research Institute of Environmental Medicine (US)
ORCID: Cheuvront, Samuel N
Ely, Brett R
Sawka, Michael N
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2010-09
Volume: 92
Issue: 3
Pages: 565-573
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.2010.29490
OpenAlex: W1997497052
Cited by: 367
References: 62
Citations by year: 2026: 12 · 2025: 20 · 2024: 26 · 2023: 21 · 2022: 18 · 2021: 29 · 2020: 28 · 2019: 34 · 2018: 26 · 2017: 20 · 2016: 29 · 2015: 28 · 2014: 20 · 2013: 21 · 2012: 23
FWCI: 11.91
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 4556 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords: dehydration assessment, biological variation, plasma osmolality, urine specific gravity, body mass, reference change value, diagnostic accuracy, within-person variability, fluid balance, military medicine, sports medicine
MeSH terms: Adult, Body Weight, Dehydration, Female, Humans, Male, Osmolar Concentration, Prospective Studies, Reference Values, ROC Curve, Saliva, Specific Gravity, Biomarkers, Young Adult

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Biological variation and diagnostic accuracy of dehydration assessment markers

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