The DOI matches its Crossref record; 159 of the 160 references it cites were found in a registry or an index.
(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights
Open accessAbstract
Obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. Chronic low-grade inflammation occurring in the adipose tissue of obese individuals is causally linked to the pathogenesis of insulin resistance and the metabolic syndrome. Although the exact trigger of this inflammatory process is unknown, adipose tissue hypoxia, endoplasmic reticular stress, and saturated fatty acid-mediated activation of innate immune processes have been identified as important processes in these disorders. Furthermore, macrophages and T lymphocytes have important roles in orchestrating this immune process. Although energy restriction leading to weight loss is the primary dietary intervention to reverse these obesity-associated metabolic disorders, other interventions targeted at alleviating adipose tissue inflammation have not been explored in detail. In this regard, (n-3) PUFA of marine origin both prevent and reverse high-fat-diet-induced adipose tissue inflammation and insulin resistance in rodents. We provide an update on the pathogenesis of adipose tissue inflammation and insulin resistance in obesity and discuss potential mechanisms by which (n-3) PUFA prevent and reverse these changes and the implications in human health.
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“n-3 PUFAs are well known for their anti-inflammatory, cardioprotective and hypotriglyceridemic effects, which we have reviewed previously [10,11,12].”
From Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in Polycystic Ovary Syndrome (2024) · cites this paper as [12]
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1 retracted
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Satija, A., Bhupathiraju, S. N., Rimm, E. B., Spiegelman, D., Chiuve, S. E., Borgi, L., Willett, W. C., Manson, J. E., Sun, Q., & Hu, F. B. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002039 · Cited by 1,069
Novel insights of dietary polyphenols and obesity
Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 929
Modulation of adipose tissue inflammation by bioactive food compounds
Siriwardhana, N., Kalupahana, N. S., Cekanova, M., LeMieux, M. J., Greer, B. P., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.013 · Cited by 360
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The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance
Kalupahana, N. S., & Moustaïd‐Moussa, N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00942.x · Cited by 284
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Metadata
- Authors
- Kalupahana, N. S., Claycombe, K. J., & Moustaid-Moussa, N.
- Affiliations
- University of Peradeniya (LK)
- Agricultural Research Service (US)
- Venue
- Advances in Nutrition
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 2
- Issue
- 4
- Pages
- 304-316
- ISSN
- 2156-5376 (ISSN-L)
- 2161-8313
- PMC
- PMC3125680
- OpenAlex
- W2058154833
- Cited by
- 305
- References
- 160
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 13 · 2023: 9 · 2022: 16 · 2021: 20 · 2020: 23 · 2019: 24 · 2018: 19 · 2017: 23 · 2016: 26 · 2015: 30 · 2014: 30 · 2013: 37 · 2012: 12
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Advances in Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- AgResearch
- National Institute of Food and Agriculture (2005-35200, 2005-35200-15224)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- omega-3 fatty acids, adipose tissue inflammation, insulin resistance, obesity, metabolic syndrome, type 2 diabetes, adipose tissue hypoxia, endoplasmic reticulum stress, innate immunity, macrophages, T cells, high-fat diet, caloric restriction, marine fatty acids
- MeSH terms
- Adipose Tissue, Animals, Docosahexaenoic Acids, Humans, Inflammation, Insulin Resistance, Obesity, Eicosapentaenoic Acid, Metabolic Syndrome, Rats
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