(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity

Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

The chemokine system in diverse forms of macrophage activation and polarization

MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Fish Consumption, Fish Oil, Omega-3 Fatty Acids, and Cardiovascular Disease

Kris-Etherton, P. M., Harris, W. S., & Appel, L. J. (2002) · Circulation · doi:10.1161/01.cir.0000038493.65177.94 · Cited by 3,707

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359

Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents

Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061

The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases

Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 3,003

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

Macrophages, inflammation, and insulin resistance

Olefsky, J. M., & Glass, C. K. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135846 · Cited by 2,733

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682

Type 2 diabetes: principles of pathogenesis and therapy

Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428

AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity

Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245

Subcutaneous and visceral adipose tissue: Structural and functional differences

Ibrahim, M. M. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00623.x · Cited by 2,238

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145

IKK-β links inflammation to obesity-induced insulin resistance

Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773

Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40

Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P., Hunter, D., Huber, R., Lemieux, J., Slaymaker, S., Vaddi, K., Charo, I., Leibel, R. L., & Jr., A. W. F. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335 · Cited by 1,497

CCR2 modulates inflammatory and metabolic effects of high-fat feeding

Weisberg, S. P. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24335c1 · Cited by 1,425

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370

Relationship between Adipocyte Size and Adipokine Expression and Secretion

Skurk, T., Alberti-Huber, C., Herder, C., & Hauner, H. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1055 · Cited by 1,288

Resolvin E1 and protectin D1 activate inflammation-resolution programmes

Schwab, J. M., Chiang, N., Arita, M., & Serhan, C. N. (2007) · Nature · doi:10.1038/nature05877 · Cited by 1,219

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191

Adiponectin and development of type 2 diabetes in the Pima Indian population

Lindsay, R. S., Funahashi, T., Hanson, R. L., Matsuzawa, Y., Tanaka, S., Tataranni, P. A., Knowler, W. C., & Krakoff, J. A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09335-2 · Cited by 1,094

Identification and characterization of metabolically benign obesity in humans

Stefan, N. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.15.1609 · Cited by 1,049

Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid

Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967

Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes

Lumeng, C. N.-K., DelProposto, J. B., Westcott, D. J., & Saltiel, A. R. (2008) · Diabetes · doi:10.2337/db08-0872 · Cited by 956

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904

Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action

Yang, R.-Z., Lee, M.-J., Hu, H., Pray, J., Wu, H.-B., Hansen, B. C., Shuldiner, A. R., Fried, S. K., McLenithan, J. C., & Gong, D.-W. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00572.2004 · Cited by 884

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

Blasbalg, T. L., Hibbeln, J. R., Ramsden, C. E., Majchrzak, S. F., & Rawlings, R. R. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006643 · Cited by 881

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob / ob and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840

Reduced Adipose Tissue Oxygenation in Human Obesity

Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786

Fish Oil Prevents Insulin Resistance Induced by High-Fat Feeding in Rats

Storlien, L. H., Kraegen, E. W., Chisholm, D. J., Ford, G. L., Bruce, D. G., & Pascoe, W. S. (1987) · Science · doi:10.1126/science.3303333 · Cited by 648

Evolutionary Aspects of Diet: The Omega-6/Omega-3 Ratio and the Brain

Simopoulos, A. P. (2011) · Molecular Neurobiology · doi:10.1007/s12035-010-8162-0 · Cited by 627

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

Kennedy, A. J., Martinez, K., Chuang, C., LaPoint, K., & McIntosh, M. (2008) · Journal of Nutrition · doi:10.3945/jn.108.098269 · Cited by 579

Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production

Zeyda, M., Farmer, D., Todoric, J., Aszmann, O. C., Speiser, M., Györi, G., Zlabinger, G. J., & Stulnig, T. M. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803632 · Cited by 575

Obesity‐induced insulin resistance and hepatic steatosis are alleviated by ω‐3 fatty acids: a role for resolvins and protectins

González‐Périz, A., Horrillo, R., Ferré, N., Gronert, K., Dong, B., Morán‐Salvador, E., Titos, E., Martínez‐Clemente, M., López‐Parra, M., Arroyo, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125674 · Cited by 567

Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation

Massiéra, F., Bloch-Faure, M., Ceiler, D. L., Murakami, K., Fukamizu, A., Gasc, J., Quignard‐Boulangé, A., Négrel, R., Ailhaud, G. P., Seydoux, J., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0457fje · Cited by 505

Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH

Bekri, S., Gual, P., Anty, R., Luciani, N., Dahman, M., Ramesh, B., Iannelli, A., Staccini–Myx, A., Casanova, D., Ben Amor, I., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.007 · Cited by 496

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411860200 · Cited by 469

Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

Boden, G., Duan, X., Homko, C., Molina, E. J., Song, W., Perez, O., Cheung, P., & Merali, S. (2008) · Diabetes · doi:10.2337/db08-0604 · Cited by 468

Insulin signaling meets mitochondria in metabolism

Cheng, Z., Tseng, Y. D., & White, M. F. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.06.005 · Cited by 460

Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation

Chavey, C., Mari, B. P., Monthouel, M.-N., Bonnafous, S., Anglard, P., OBBERGHEN, E. V., & Tartare‐Deckert, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209196200 · Cited by 451

SOCS-3 Inhibits Insulin Signaling and Is Up-regulated in Response to Tumor Necrosis Factor-α in the Adipose Tissue of Obese Mice

Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects

Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 424

Resistin, central obesity, and type 2 diabetes

McTernan, C. L., McTernan, P. G., Harte, A. L., Levick, P., Barnett, A. H., & Kumar, S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07281-1 · Cited by 421

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression

Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.028 · Cited by 415

Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass

Klöting, N., Graham, T. E., Berndt, J., Kralisch, S., Kovacs, P. L., Wason, C. J., Faßhauer, M., Schön, M. R., Stümvoll, M., Blüher, M., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.002 · Cited by 405

Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce β-oxidation in white fat

Flachs, P., Horakova, O., Brauner, P., Rossmeisl, M., Pecina, P., Franssen-van Hal, N., Ruzickova, J., Sponarova, J., Drahota, Z., Vlcek, C., et al. (2005) · Diabetologia · doi:10.1007/s00125-005-1944-7 · Cited by 388

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

Prieur, X., Mok, C. Y. L., Velagapudi, V. R., Núñez, V., Fuentes, L., Montaner, D., Ishikawa, K., Camacho, A., Barbarroja, N., O’Rahilly, S., et al. (2011) · Diabetes · doi:10.2337/db10-0705 · Cited by 381

Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet

Flachs, P., Mohamed‐Ali, V., Horakova, O., Rossmeisl, M., Hosseinzadeh‐Attar, M. J., Hensler, M., Ruzickova, J., & Kopecký, J. (2006) · Diabetologia · doi:10.1007/s00125-005-0053-y · Cited by 362

Acute-Phase Serum Amyloid A: An Inflammatory Adipokine and Potential Link between Obesity and Its Metabolic Complications

Yang, R., Lee, M., Hu, H., Pollin, T. I., Ryan, A. S., Nicklas, B. J., Snitker, S., Horenstein, R. B., Hull, K., Goldberg, N. H., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030287 · Cited by 354

Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults

Couet, C., Delarue, J., Ritz, P., Antoine, J.-M., & Lamisse, F. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800451 · Cited by 344

n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: A review

Nettleton, J. A., & Katz, R. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.11.029 · Cited by 341

Vaspin gene expression in human adipose tissue: Association with obesity and type 2 diabetes

Klöting, N., Berndt, J., Kralisch, S., Kovacs, P. L., Faßhauer, M., Schön, M. R., Stümvoll, M., & Blüher, M. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.11.039 · Cited by 339

Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice

Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., & Kotani, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309895200 · Cited by 327

Omega‐3 PUFA of marine origin limit diet‐induced obesity in mice by reducing cellularity of adipose tissue

Ruzickova, J., Rossmeisl, M., Prazak, T., Flachs, P., Sponarova, J., Vecka, M., TVRZICKÁ, E., Bryhn, M., & Kopecký, J. (2004) · Lipids · doi:10.1007/s11745-004-1345-9 · Cited by 327

Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance

Zick, Y. (2005) · Science s STKE · doi:10.1126/stke.2682005pe4 · Cited by 326

The secretory function of adipocytes in the physiology of white adipose tissue

Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318

Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318

Adipose tissue macrophages

Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316

Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: A randomized controlled study

Kabir, M., Skurnik, G., Naour, N., Pechtner, V., Meugnier, E., Rome, S., Quignard-Boulangé, A., Vidal, H., Slama, G., Clément, K., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1670 · Cited by 316

Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

Dentin, R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25256 · Cited by 315

Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae

DeFuria, J., Bennett, G., Strissel, K. J., James, W. P., Milbury, P. E., Greenberg, A. S., & Obin, M. S. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.105155 · Cited by 313

Eicosapentaenoic Acid Prevents and Reverses Insulin Resistance in High-Fat Diet-Induced Obese Mice via Modulation of Adipose Tissue Inflammation1–3

Kalupahana, N. S., Claycombe, K., Newman, S. J., Stewart, T. P., Siriwardhana, N., Matthan, N. R., Lichtenstein, A. H., & Moustaïd‐Moussa, N. (2010) · Journal of Nutrition · doi:10.3945/jn.110.125732 · Cited by 301

Inflammation and impaired adipogenesis in hypertrophic obesity in man

Gustafson, B., Gogg, S., Hedjazifar, S., Jenndahl, L. E., Hammarstedt, A., & Smith, U. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00377.2009 · Cited by 298

The unfolded protein response—a stress signaling pathway of the endoplasmic reticulum

Shen, X., Zhang, K., & Kaufman, R. J. (2004) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2004.02.006 · Cited by 294

Dietary fish as a major component of a weight-loss diet: effect on serum lipids, glucose, and insulin metabolism in overweight hypertensive subjects

Mori, T. A., Bao, D. Q., Burke, V., Puddey, I. B., Watts, G. F., & Beilin, L. J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.817 · Cited by 294

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

Flachs, P., Rossmeisl, M., Bryhn, M., & Kopecký, J. (2008) · Clinical Science · doi:10.1042/cs20070456 · Cited by 293

Increased Adiponectin Secretion by Highly Purified Eicosapentaenoic Acid in Rodent Models of Obesity and Human Obese Subjects

Itoh, M., Suganami, T., Satoh, N., Tanimoto-Koyama, K., Yuan, X., Tanaka, M., Kawano, H., Yano, T., Aoe, S., Takeya, M., et al. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.106.136853 · Cited by 292

Eicosapentaenoic acid reduces hepatic synthesis and secretion of triacylglycerol by decreasing the activity of acyl-coenzyme A:1,2-diacylglycerol acyltransferase

Rustan, A. C., Nossen, J. Ø., Christiansen, E. N., & Drevon, C. A. (1988) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38418-2 · Cited by 288

Dietary docosahexaenoic and eicosapentaenoic acid: Emerging mediators of inflammation

Chapkin, R. S., Kim, W., Lupton, J. R., & McMurray, D. N. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.05.010 · Cited by 282

Fish Oil Regulates Adiponectin Secretion by a Peroxisome Proliferator–Activated Receptor-γ–Dependent Mechanism in Mice

Neschen, S., Morino, K., Rossbacher, J. C., Pongratz, R. L., Cline, G. W., Sono, S., Gillum, M. P., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-0985 · Cited by 275

Modulation of Adipose Tissue Expression of Murine Matrix Metalloproteinases and Their Tissue Inhibitors With Obesity

Maquoi, E., Munaut, C., Colige, A., Collen, D., & Lijnen, H. R. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1093 · Cited by 271

A Model of Insulin Resistance and Nonalcoholic Steatohepatitis in Rats

Svegliati‐Baroni, G., Candelaresi, C., Saccomanno, S., Ferretti, G., Bachetti, T., Marzioni, M., Minicis, S. D., Nobili, L., Salzano, R., Omenetti, A., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050953 · Cited by 258

Relation of C-Reactive Protein to Abdominal Adiposity

Brooks, G. C., Blaha, M. J., & Blumenthal, R. S. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.02.017 · Cited by 255

Secretory, Endocrine and Autocrine/Paracrine Function of the Adipocyte

Kim, S., & Moustaïd‐Moussa, N. (2000) · Journal of Nutrition · doi:10.1093/jn/130.12.3110s · Cited by 244

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Ehses, J. A., Meier, D. T., Wueest, S., Rytka, J. M., Boller, S., Wielinga, P. Y., Schraenen, A., Lemaire, K., Debray, S., Lommel, L. V., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1747-3 · Cited by 243

n-3 Fatty Acids Preserve Insulin Sensitivity In Vivo in a Peroxisome Proliferator–Activated Receptor-α–Dependent Manner

Neschen, S., Morino, K., Dong, J., Wang-Fischer, Y., Cline, G. W., Romanelli, A. J., Rossbacher, J. C., Moore, I. K., Regittnig, W., Muñoz, D. S., et al. (2007) · Diabetes · doi:10.2337/db06-1206 · Cited by 236

Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

Pettinelli, P., del Pozo, T., Julia Araya, A., Rodrigo, R., Araya, A. V., Smok, G., Csendes, A., Gutiérrez, L., Rojas, J., Owen Korn, B., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.08.015 · Cited by 233

Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation

Suganami, T., Mieda, T., Itoh, M., Shimoda, Y., Kamei, Y., & Ogawa, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.190 · Cited by 230

Additive benefits of long-chain n-3 polyunsaturated fatty acids and weight-loss in the management of cardiovascular disease risk in overweight hyperinsulinaemic women

Krebs, J. D., Browning, L. M., McLean, N., Rothwell, J. L., Mishra, G. D., Moore, C. S., & Jebb, S. A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803309 · Cited by 228

Role of adipose tissue renin–angiotensin system in metabolic and inflammatory diseases associated with obesity

Yvan‐Charvet, L., & Quignard‐Boulangé, A. (2010) · Kidney International · doi:10.1038/ki.2010.391 · Cited by 221

Fatty Acid-induced Insulin Resistance in L6 Myotubes Is Prevented by Inhibition of Activation and Nuclear Localization of Nuclear Factor κB

Sinha, S., Perdomo, G., Brown, N. F., & O'Doherty, R. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406514200 · Cited by 219

-Adrenergic Regulation of IL-6 Release from Adipose Tissue: In Vivo and in Vitro Studies

Mohamed‐Ali, V., Flower, L., Sethi, J. K., Hotamışlıgil, G. S., Gray, R. P., Humphries, S. E., York, D. A., & Pinkney, J. H. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8104 · Cited by 204

SPARC: a key player in the pathologies associated with obesity and diabetes

Kos, K., & Wilding, J. P. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.18 · Cited by 197

Thrombospondin-1 Is an Adipokine Associated With Obesity, Adipose Inflammation, and Insulin Resistance

Varma, V., Yao-Borengasser, A., Bodles, A. M., Rasouli, N., Phanavanh, B., Nolen, G. T., Kern, E. M., Nagarajan, R., Spencer, H. J., Lee, M.-J., et al. (2008) · Diabetes · doi:10.2337/db07-0840 · Cited by 194

Regulation of Interleukin 8 Production and Gene Expression in Human Adipose Tissue in Vitro

Bruun, J. M., Pedersen, S. B., & Richelsen, B. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7264 · Cited by 192

Nutritional Supplementation Withtrans-10,cis-12–Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue

Poirier, H., Shapiro, J. S., Kim, R. J., & Lazar, M. A. (2006) · Diabetes · doi:10.2337/db06-0036 · Cited by 188

Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference

Madsen, L., Rustan, A. C., Vaagenes, H., Berge, K., Dyrøy, E., & Berge, R. K. (1999) · Lipids · doi:10.1007/s11745-999-0445-x · Cited by 186

Transgenic restoration of long-chain n-3 fatty acids in insulin target tissues improves resolution capacity and alleviates obesity-linked inflammation and insulin resistance in high-fat-fed mice

White, P. J., Arita, M., Taguchi, R., Kang, J. X., & Marette, A. (2010) · Diabetes · doi:10.2337/db10-0054 · Cited by 185

Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production

Gealekman, O., Burkart, A., Chouinard, M., Nicoloro, S. M. C., Straubhaar, J., & Corvera, S. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90345.2008 · Cited by 180

Angiotensinogen gene expression in adipose tissue: analysis of obese models and hormonal and nutritional control

Jones, B. H., Standridge, M. K., Taylor, J. W., & Moustaïd, N. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.1.r236 · Cited by 176

Expression of Interleukin-6 Is Greater in Preadipocytes than in Adipocytes of 3T3-L1 Cells and C57BL/6J and ob/ob Mice

Claycombe, K., Harkins, J. M., Chung, Y.-J., Penner, K. M., Pestka, J. J., North, C. M., & Moustaïd‐Moussa, N. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2673 · Cited by 169

Long-Term Effects of Fish Oil on Insulin Resistance and Plasma Lipoproteins in NIDDM Patients With Hypertriglyceridemia

Rivellese, A. A., Maffettone, A., Iovine, C., Marino, L. D., Annuzzi, G., Mancini, M., & Riccardi, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.11.1207 · Cited by 166

Uncoupling of Inflammation and Insulin Resistance by NF-κB in Transgenic Mice through Elevated Energy Expenditure

Tang, T., Zhang, J., Yin, J., Staszkiewicz, J., Gawrońska‐Kozak, B., Jung, D. Y., Ko, H. J., Ong, H., Kim, J. K., Mynatt, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068007 · Cited by 164

T-ing up inflammation in fat

Lumeng, C. N.-K., Maillard, I. P., & Saltiel, A. R. (2009) · Nature Medicine · doi:10.1038/nm0809-846 · Cited by 162

Effect of hypocaloric diet-induced weight loss in obese women on plasma apelin and adipose tissue expression of apelin and APJ.

Castan‐Laurell, I., Šiklová, M., Daviaud, D., Dray, C., Kováčiková, M., Kováčová, Z., Hejnová, J., Štich, V., & Valet, P. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0039 · Cited by 161

Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation

STRATFORD, S., DEWALD, D. B., & SUMMERS, S. A. (2001) · Biochemical Journal · doi:10.1042/bj3540359 · Cited by 161

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

Neschen, S., Moore, I. K., Regittnig, W., Yu, C. L., Wang, Y., Pypaert, M., Petersen, K. F., & Shulman, G. I. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00414.2001 · Cited by 155

NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines

Peeraully, R., Jenkins, J. R., & Trayhurn, P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00076.2004 · Cited by 143

n-3 Fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet

Kuda, O., Jelenik, T., Jilkova, Z., Flachs, P., Rossmeisl, M., Hensler, M., Kazdova, L., Ogston, N., Baranowski, M., Gorski, J., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1305-z · Cited by 142

Overproduction of Angiotensinogen from Adipose Tissue Induces Adipose Inflammation, Glucose Intolerance, and Insulin Resistance

Kalupahana, N. S., Massiéra, F., Quignard‐Boulangé, A., Ailhaud, G. P., Voy, B. H., Wasserman, D. H., & Moustaïd‐Moussa, N. (2011) · Obesity · doi:10.1038/oby.2011.299 · Cited by 140

Interaction of Fish Oil and Conjugated Linoleic Acid in Affecting Hepatic Activity of Lipogenic Enzymes and Gene Expression in Liver and Adipose Tissue

Ide, T. (2005) · Diabetes · doi:10.2337/diabetes.54.2.412 · Cited by 129

Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats

Suchánková, G., Tekle, M., Saha, A. K., Ruderman, N. B., Clarke, S. D., & Gettys, T. W. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.114 · Cited by 116

Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice

Zhang, X., Xu, A., Chung, S. K., Cresser, J., Sweeney, G., Wong, R. L. C., Lin, A., & Lam, K. S. L. (2011) · Diabetes · doi:10.2337/db10-0650 · Cited by 116

Presence of functional TLR2 and TLR4 on human adipocytes

Bès-Houtmann, S., Roche, R., Hoareau, L., Gonthier, M., Festy, F., Caillens, H., Gasque, P., d’Hellencourt, C. L., & Césari, M. (2006) · Histochemistry and Cell Biology · doi:10.1007/s00418-006-0230-1 · Cited by 114

Macrophage Adiponectin Expression Improves Insulin Sensitivity and Protects Against Inflammation and Atherosclerosis

Luo, N., Liu, J., Chung, B. H., Yang, Q., Klein, R. L., Garvey, W. T., & Fu, Y. (2010) · Diabetes · doi:10.2337/db09-1338 · Cited by 114

Effects of eicosapentaenoic acid (EPA) treatment on insulin sensitivity in an animal model of diabetes: Improvement of the inflammatory status

Figueras, M., Olivan, M., Busquets, S., López‐Soriano, F. J., & Argilés, J. M. (2011) · Obesity · doi:10.1038/oby.2010.194 · Cited by 113

The role of adipose tissue in mediating the beneficial effects of dietary fish oil

Puglisi, M. J., Hasty, A. H., & Saraswathi, V. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.003 · Cited by 108

Regulatory Effects of Interleukin (IL)-1, Interferon-β, and IL-4 on the Production of IL-1 Receptor Antagonist by Human Adipose Tissue

Juge-Aubry, C. E., Somm, E., Chicheportiche, R., Burger, D., Pernin, A., Pittet-Cuenod, B. M., Quinodoz, P., Giusti, V., Dayer, J., & Meier, C. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031219 · Cited by 108

Expression of Human Chemerin Induces Insulin Resistance in the Skeletal Muscle but Does Not Affect Weight, Lipid Levels, and Atherosclerosis in LDL Receptor Knockout Mice on High-Fat Diet

Becker, M., Rabe, K., Lebherz, C., Zugwurst, J., Göke, B., Parhofer, K. G., Lehrke, M., & Broedl, U. C. (2010) · Diabetes · doi:10.2337/db10-0362 · Cited by 108

Effects of Statins on Adipose Tissue Inflammation

Abe, M., Matsuda, M., Kobayashi, H., Miyata, Y., Nakayama, Y., Komuro, R., Fukuhara, A., & Shimomura, I. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.160663 · Cited by 106

Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c

Teran-Garcia, M., Adamson, A. W., Yu, G., Rufo, C., Suchankova, G., Dreesen, T. D., Tekle, M., Clarke, S. D., & Gettys, T. W. (2007) · Biochemical Journal · doi:10.1042/bj20061722 · Cited by 104

Trans-10, cis-12 conjugated linoleic acid causes inflammation and delipidation of white adipose tissue in mice: a microarray and histological analysis

LaRosa, P. C., Miner, J. L., Xia, Y., Zhou, Y., Kachman, S. D., & Fromm, M. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00076.2006 · Cited by 104

Fish Oil Increases Cholesterol Storage in White Adipose Tissue with Concomitant Decreases in Inflammation, Hepatic Steatosis, and Atherosclerosis in Mice

Saraswathi, V., Gao, L., Morrow, J. D., Chait, A., Niswender, K. D., & Hasty, A. H. (2007) · Journal of Nutrition · doi:10.1093/jn/137.7.1776 · Cited by 103

Adipocytes as Immune Cells: Differential Expression of TWEAK, BAFF, and APRIL and Their Receptors (Fn14, BAFF-R, TACI, and BCMA) at Different Stages of Normal and Pathological Adipose Tissue Development

Alexaki, V. I., Notas, G., Pelekanou, V., Kampa, M., Valkanou, M., Theodoropoulos, P. A., Stathopoulos, E. N., Tsapis, A., & Castanas, E. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901186 · Cited by 103

Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells

Aas, V., Rokling-Andersen, M. H., Kase, E. T., Thoresen, G. H., & Rustan, A. C. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m500300-jlr200 · Cited by 101 · cited 1×

Endurance training induces depot-specific changes in IL-10/TNF-alpha ratio in rat adipose tissue.

Lira, F. S., Neto, J. C. R., Yamashita, A. S., Koyama, C. H., Júnior, M. L. B., & Seelaender, M. C. L. (2009) · PubMed · doi:10.1016/j.cyto.2008.10.018 · Cited by 100

PAI-1 Produced Ex Vivo by Human Adipose Tissue Is Relevant to PAI-1 Blood Level

Morange, P., Alessi, M., Verdier, M., Casanova, D., Magalon, G., & Juhan-Vague, I. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.5.1361 · Cited by 100

The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFα in human adipocytes

Wood, I. S., Wang, B., Jenkins, J. R., & Trayhurn, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.068 · Cited by 94

AMP-activated protein kinase α2 subunit is required for the preservation of hepatic insulin sensitivity by n-3 polyunsaturated fatty acids

Jelenik, T., Rossmeisl, M., Kuda, O., Jilkova, Z. M., Medrikova, D., Kus, V., Hensler, M., Janovska, P., Miksik, I., Baranowski, M., et al. (2010) · Diabetes · doi:10.2337/db09-1716 · Cited by 88

Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass

Kos, K., Harte, A. L., James, S. G., Snead, D. R. J., O’Hare, J. P., McTernan, P. G., & Kumar, S. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00333.2007 · Cited by 87

Eicosapentaenoic acid stimulates AMP-activated protein kinase and increases visfatin secretion in cultured murine adipocytes

Lorente‐Cebrián, S., Bustos, M., Martí, A., Martínez, J. A., & Moreno-Aliaga, M. J. (2009) · Clinical Science · doi:10.1042/cs20090020 · Cited by 80

Dietary (n-3) Long Chain Polyunsaturated Fatty Acids Prevent Sucrose-Induced Insulin Resistance in Rats

Ghafoorunissa, Ibrahim, A., Rajkumar, L. A. P., & Acharya, V. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2634 · Cited by 79

Visfatin mRNA expression in human subcutaneous adipose tissue is regulated by exercise

Frydelund‐Larsen, L., Akerstrom, T. C. A., Nielsen, S. J., Keller, P., Keller, C., & Pedersen, B. K. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00113.2006 · Cited by 78

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation

Wensaas, A. J., Rustan, A. C., Just, M., Berge, R. K., Drevon, C. A., & Gaster, M. (2009) · Diabetes · doi:10.2337/db08-1043 · Cited by 73

Eicosapentaenoic acid, but not oleic acid, stimulates β‐oxidation in adipocytes

Guo, W., Xie, W., Lei, T., & Hamilton, J. A. (2005) · Lipids · doi:10.1007/s11745-005-1443-8 · Cited by 72

Angiotensin II Increases Leptin Secretion by 3T3-L1 and Human Adipocytes via a Prostaglandin-Independent Mechanism

Kim, S., Whelan, J., Moustaïd‐Moussa, N., Claycombe, K., & Reath, D. B. (2002) · Journal of Nutrition · doi:10.1093/jn/132.6.1135 · Cited by 71

Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet

van Schothorst, E. M., Flachs, P., Franssen-van Hal, N. L., Kuda, O., Bunschoten, A., Molthoff, J., Vink, C., Hooiveld, G. J., Kopecky, J., & Keijer, J. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-110 · Cited by 64

Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats

Pérez-Echarri, N., Pérez‐Matute, P., Marcos‐Gómeź, B., Martínez, J. A., & Moreno-Aliaga, M. J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508048307 · Cited by 63

Targeting Ceramide Synthesis to Reverse Insulin Resistance

Schmitz‐Peiffer, C. (2010) · Diabetes · doi:10.2337/db10-0912 · Cited by 62

Low Levels of the Omega‐3 Index are Associated with Sudden Cardiac Arrest and Remain Stable in Survivors in the Subacute Phase

Aarsetoey, H., Aarsetoey, R., Lindner, T. W., Staines, H., Harris, W. S., & Nilsen, D. W. T. (2011) · Lipids · doi:10.1007/s11745-010-3511-3 · Cited by 61

Stearidonic and Eicosapentaenoic Acids Inhibit Interleukin-6 Expression in ob/ob Mouse Adipose Stem Cells via Toll-Like Receptor-2Mediated Pathways

Hsueh, H. W., Zhou, Z., Whelan, J., Allen, K. G. D., Moustaïd‐Moussa, N., Kim, H., & Claycombe, K. (2011) · Journal of Nutrition · doi:10.3945/jn.110.132571 · Cited by 57

Nuclear receptors and hepatic lipidogenic enzyme response to a dyslipidemic sucrose-rich diet and its reversal by fish oil n-3 polyunsaturated fatty acids

Hein, G. J., Bernasconi, A. M., Montanaro, M. A., Maisón, M. P., Finarelli, G. S., Chicco, A. G., Lombardo, Y. B., & Brenner, R. R. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00513.2009 · Cited by 55

Early postprandial low-grade inflammation after high-fat meal in healthy rats: possible involvement of visceral adipose tissue

Magné, J., Mariotti, F., Fischer, R., Mathé, V., Tomé, D., & Huneau, J. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.03.004 · Cited by 54

Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment

Pérez-Echarri, N., Pérez‐Matute, P., Marcos‐Gómeź, B., Baena, M. J., Martí, A., Martínez, J. A., & Moreno-Aliaga, M. J. (2008) · European Journal of Nutrition · doi:10.1007/s00394-008-0738-3 · Cited by 54

(n-3) Fatty Acids: Clinical Trials in People with Type 2 Diabetes

Hendrich, S. (2010) · Advances in Nutrition · doi:10.3945/an.110.1003 · Cited by 46

n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes

Wortman, P., Miyazaki, Y., Kalupahana, N. S., Kim, S., Hansen‐Petrik, M., Saxton, A. M., Claycombe, K., Voy, B. H., Whelan, J., & Moustaïd‐Moussa, N. (2009) · Nutrition & Metabolism · doi:10.1186/1743-7075-6-5 · Cited by 43

Energy‐Restricted High‐Fat Diets Only Partially Improve Markers of Systemic and Adipose Tissue Inflammation

Kalupahana, N. S., Voy, B. H., Saxton, A. M., & Moustaïd‐Moussa, N. (2010) · Obesity · doi:10.1038/oby.2010.196 · Cited by 42

Relationship between epicardial adipose tissue adipocyte size and MCP-1 expression

Eiras-Penas, S., Teijeira‐Fernández, E., Salgado‐Somoza, A., Couso, E., García‐Caballero, T., Sierra, J., & González‐Juanatey, J. R. (2010) · Cytokine · doi:10.1016/j.cyto.2010.05.009 · Cited by 42

Absence of macrophage inflammatory protein-1α does not impact macrophage accumulation in adipose tissue of diet-induced obese mice

Surmi, B. K., Webb, C. D., Ristau, A. C., & Hasty, A. H. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00050.2010 · Cited by 40

P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance

Sato, C., Shikata, K., Hirota, D., Sasaki, M., Nishishita, S., Miyamoto, S., Kodera, R., Ogawa, D., Tone, A., Kataoka, H. U., et al. (2010) · Diabetes · doi:10.2337/db09-1894 · Cited by 36

Obesity-associated mouse adipose stem cell secretion of monocyte chemotactic protein-1

Zhou, H. R., Kim, E., Kim, H., & Claycombe, K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00186.2007 · Cited by 35

Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats

Kusunoki, M., Tsutsumi, K., Hara, T., Ogawa, H., Nakamura, T., Miyata, T., Sakakibara, F., Fukuzawa, Y., Suga, T., Kato, K., et al. (2003) · Metabolism · doi:10.1053/meta.2003.50012 · Cited by 21

Plant-Based Dietary Patterns and Incidence of Type 2 Diabetes in US Men and Women: Results from Three Prospective Cohort Studies

Satija, A., Bhupathiraju, S. N., Rimm, E. B., Spiegelman, D., Chiuve, S. E., Borgi, L., Willett, W. C., Manson, J. E., Sun, Q., & Hu, F. B. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1002039 · Cited by 1,069

Novel insights of dietary polyphenols and obesity

Wang, S. F., Moustaïd‐Moussa, N., Chen, L., Mo, H., Shastri, A. A., Su, R., Bapat, P., Kwun, I., & Shen, C. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.001 · Cited by 929

Modulation of adipose tissue inflammation by bioactive food compounds

Siriwardhana, N., Kalupahana, N. S., Cekanova, M., LeMieux, M. J., Greer, B. P., & Moustaïd‐Moussa, N. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.12.013 · Cited by 360

Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures

Patsch, J., Li, X., Baum, T. H., Yap, S. P., Karampinos, D. C., Schwartz, A. V., & Link, T. M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1950 · Cited by 331

The renin‐angiotensin system: a link between obesity, inflammation and insulin resistance

Kalupahana, N. S., & Moustaïd‐Moussa, N. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00942.x · Cited by 284

REVIEW (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance:

Insights, M., Kalupahana, N. S., Claycombe, K. J., & Moustaïd‐Moussa, N. (2015)

n-3 PUFA: bioavailability and modulation of adipose tissue function

Kopecký, J., Rossmeisl, M., Flachs, P., Kuda, O., Brauner, P., Jílková, Z. M., Staňková, B., TVRZICKÁ, E., & Bryhn, M. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990231 · Cited by 138

Role of n-3 Polyunsaturated Fatty Acids in Ameliorating the Obesity-Induced Metabolic Syndrome in Animal Models and Humans

Huang, C., Chien, Y.-S., Chen, Y.-J., Ajuwon, K. M., Mersmann, H. J., & Ding, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17101689 · Cited by 107

Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n−3 polyunsaturated fatty acids

Todoric, J., Löffler, M. G., Huber, J., Bilban, M., Reimers, M., Kadl, A., Zeyda, M., Waldhäusl, W., & Stulnig, T. M. (2006) · Diabetologia · doi:10.1007/s00125-006-0300-x · Cited by 318

Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome

Martínez‐Fernández, L., Laiglesia, L. M., Huerta, A. E., Martínez, J. A., & Moreno-Aliaga, M. J. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.07.003 · Cited by 218