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Cited by 213Selenium in Biological SystemsOrganoselenium and organotellurium chemistryT-cell and B-cell Immunology

Dietary Selenium Modulates Activation and Differentiation of CD4+ T Cells in Mice through a Mechanism Involving Cellular Free Thiols

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Hoffmann, FuKun W., Hashimoto, Ann C., Shafer, Leigh Anne, Dow, Steven, Berry, Marla J., Hoffmann, Peter R.·2010·The Journal of Nutrition
DOI 10.3945/jn.109.120725PMC PMC2869499
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Abstract

The immune-enhancing effects of selenium (Se) supplementation make it a promising complementary and alternative medicine modality for boosting immunity, although mechanisms by which Se influences immunity are unclear. Mice fed low (0.08 mg/kg), medium (0.25 mg/kg), or high (1.0 mg/kg) Se diets for 8 wk were challenged with peptide/adjuvant. Antigen-specific CD4(+) T cell responses were increased in the high Se group compared with the low and medium Se groups. T cell receptor signaling in ex vivo CD4(+) T cells increased with increasing dietary Se, with all 3 groups differing from one another in terms of calcium mobilization, oxidative burst, translocation of nuclear factor of activated T cells, and proliferation. The high Se diet increased expression of interleukin (IL)-2 and the high affinity chain of the IL-2 receptor compared with the low and medium Se diets. The high Se diet skewed the T helper (Th)1/Th2 balance toward a Th1 phenotype, leading to higher interferon-gamma and CD40 ligand levels compared with the low and medium Se diets. Prior to CD4(+) T cell activation, levels of reactive oxygen species did not differ among the groups, but the low Se diet decreased free thiols compared with the medium and high Se diets. Addition of exogenous free thiols eliminated differences in CD4(+) T cell activation among the dietary groups. Overall, these data suggest that dietary Se levels modulate free thiol levels and specific signaling events during CD4(+) T cell activation, which influence their proliferation and differentiation.

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  • Strong links have been shown between antioxidant supplementation and T cell function at rest.

    “Although strong links have been shown between antioxidant supplementation and T cell function at rest (Hoffmann et al. 2010; Malmberg et al. 2002; Marthandan et al. 2013, 2014)”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Hoffmann et al. 2010

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Authors
Hoffmann, F. W., Hashimoto, A. C., Shafer, L. A., Dow, S., Berry, M. J., & Hoffmann, P. R.
Affiliations
  • University of Hawaiʻi at Mānoa (US)
  • Colorado State University (US)
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2010-06
Volume
140
Issue
6
Pages
1155-1161
ISSN
0022-3166 (ISSN-L)
DOI
10.3945/jn.109.120725
PMC
PMC2869499
OpenAlex
W2099316303
Cited by
213
References
44
Citations by year
2026: 5 · 2025: 9 · 2024: 14 · 2023: 20 · 2022: 19 · 2021: 21 · 2020: 18 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 9 · 2015: 9 · 2014: 16 · 2013: 14 · 2012: 16
FWCI
13.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (G12RR003061, P20RR016453)
  • National Center for Complementary and Integrative Health (R21AT004844)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Organoselenium and organotellurium chemistry
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
dietary selenium, CD4+ T cells, T cell activation, T cell differentiation, free thiols, T cell receptor signaling, Th1/Th2 balance, interleukin-2, interleukin-2 receptor, interferon-gamma, CD40 ligand, respiratory burst, calcium mobilization, T cell proliferation
MeSH terms
Animals, Cell Differentiation, Gene Expression Regulation, Interleukin-2, Lymphocyte Activation, Mice, Inbred C57BL, Selenium, Sulfhydryl Compounds, Receptors, Interleukin-2, CD4-Positive T-Lymphocytes, Dietary Supplements, Cell Proliferation, Mice

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