A Mitochondria-Targeted Vitamin E Derivative Decreases Hepatic Oxidative Stress and Inhibits Fat Deposition in Mice , ,
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Our objective in this study was to determine whether a mitochondria-targeted vitamin E derivative (MitoVit E) would decrease oxidative stress and associated obesity by preventing a previously proposed aconitase inhibition cascade. Sixty-four mice were fed a high-fat (HF) diet for 5 wk. They were then switched to either a low-fat (LF) or a medium-fat (MF) diet and gavaged with MitoVit E (40 mg MitoVit E x kg body weight(-1)) or drug vehicle (10% ethanol in 0.9% NaCl solution) every other day for 5 wk. Epididymal fat weight, as well as liver lipid and remaining carcass lipid, were significantly lower in the MF group receiving MitoVit E (MF-E) than in the MF group receiving vehicle only (MF-C). Liver mitochondrial H(2)O(2) production and the protein carbonyl level were also significantly lower in MF-E than in MF-C mice. In contrast, none of the biochemical variables (aconitase activity, ATP and H(2)O(2) production, and protein carbonyl level) in the muscle mitochondria were modified by MitoVit E in either MF or LF groups. Expression of acetyl-CoA carboxylase and fatty acid synthase in both liver and adipose tissue of MF groups was not affected by MitoVit E. However, expression of carnitine palmitoyltransferase 1a in the liver and uncoupling protein 2 in adipose tissue were significantly enhanced by MitoVit E in both LF and MF groups. In conclusion, MitoVit E attenuates hepatic oxidative stress and inhibits fat deposition in mice but not through alleviation of the aconitase inhibition cascade.
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MitoQ and MitoVitE have been shown to target mitochondrial dysfunction.
“Mitochondrially-targeted coenzyme Q (MitoQ) or mitochondrially-targeted vitamin E (MitoVitE) have been shown to target mitochondrial dysfunction282,283.”
From Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022) · cites this paper as [282]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations
Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173 · see citing works
Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells
Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091 · see citing works
Complex iii releases superoxide to both sides of the inner mitochondrial membrane
Muller, F. L., Liu, Y., & Van Remmen, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407715200 · Cited by 1,036 · see citing works
Delivery of bioactive molecules to mitochondria <i>in</i> <i>vivo</i>
Smith, R. A. J., Porteous, C. M., Gane, A. M., & Murphy, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931245100 · Cited by 725 · see citing works
Malonyl-CoA, fuel sensing, and insulin resistance
Ruderman, N. B., Saha, A. K., Vavvas, D. G., & Witters, L. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e1 · Cited by 644 · see citing works
Oxidative damage during aging targets mitochondrial aconitase
Yan, L., Levine, R. L., & Sohal, R. S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11168 · Cited by 620 · see citing works
Matthews, R. T., Yang, L., Browne, S., Baik, M., & Beal, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8892 · Cited by 557 · see citing works
Selective targeting of an antioxidant to mitochondria
Smith, R. A. J., Porteous, C. M., Coulter, C. V., & Murphy, M. P. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00543.x · Cited by 466 · see citing works
Klaus, S., Pültz, S., Thöne‐Reineke, C., & Wolfram, S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802926 · Cited by 423 · see citing works
Mitochondrial dysfunction as a cause of ageing
Trifunović, A., & Larsson, N. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01905.x · Cited by 375 · see citing works
Jauslin, M. L., Meier, T., Smith, R. A. J., & Murphy, P. M. (2003) · The FASEB Journal · doi:10.1096/fj.03-0240fje · Cited by 358 · see citing works
Biochemical and Osmotic Properties of Skeletal Muscle Mitochondria
Chappell, J., & PERRY, S. V. (1954) · Nature · doi:10.1038/1731094a0 · Cited by 291 · see citing works
Dhanasekaran, A., Kotamraju, S., Kalivendi, S. V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., & Kalyanaraman, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404003200 · Cited by 241 · see citing works
Mansouri, A., Muller, F. L., Liu, Y., Ng, R., Faulkner, J., Hamilton, M., Richardson, A., Huang, T.-T., Epstein, C. J., & Van Remmen, H. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.11.004 · Cited by 227 · see citing works
Sokol, R. J., McKim, J. M., Goff, M., Ruyle, S. Z., Devereaux, M. W., Han, D., Packer, L., & Everson, G. T. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70644-4 · Cited by 199 · see citing works
Superoxide-Driven Aconitase FE-S Center Cycling
Gardner, P. R. (1997) · Bioscience Reports · doi:10.1023/a:1027383100936 · Cited by 190 · see citing works
Kent, T. A., Dreyer, J.-L., Kennedy, M. C., Huynh, B. H., Emptage, M. H., Beinert, H., & Münck, E. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.4.1096 · Cited by 179 · see citing works
Bulteau, A., Lundberg, K. C., Ikeda‐Saito, M., Isaya, G., & Szweda, L. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501519102 · Cited by 131 · see citing works
Lee, Y. M., Choi, J. S., Kim, M. H., Jung, M. H., Lee, Y. S., & Song, J. (2006) · Nutrition · doi:10.1016/j.nut.2005.12.014 · Cited by 116 · see citing works
Miquel, J., Ferrándiz, M. L., de Juan, E., Sevila, I., & Martı́nez, M. (1995) · European Journal of Pharmacology Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(95)90041-1 · Cited by 88 · see citing works
Siler‐Marsiglio, K. I., Pan, Q., Paiva, M., Madorsky, I., Khurana, N. C., & Heaton, M. B. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.030 · Cited by 74 · see citing works
Decreased energy levels can cause and sustain obesity
Wlodek, D., & Gonzales, M. (2003) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(03)00218-2 · Cited by 68 · see citing works
Cawthon, D. L., McNew, R. W., Beers, K., et al. (1999) · Poultry Science · doi:10.1093/ps/78.1.114 · Cited by 68 · see citing works
Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content
Judge, S., Judge, A. R., Grune, T., et al. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00502.2003 · Cited by 66 · see citing works
Prevention of Fatty Liver in Transition Dairy Cows by Subcutaneous Injections of Glucagon
Nafikov, R. A., Ametaj, B. N., Bobe, G., Koehler, K. J., Young, J. W., & Beitz, D. C. (2006) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(06)72221-4 · Cited by 50 · see citing works
Self-citationThe 'PREXCEL-Q Method' for qPCR
Gallup, J. M., & Ackermann, M. R. (2008) · International Journal of Biomedical Science · doi:10.59566/ijbs.2008.4273 · Cited by 49 · see citing works
Sun, X., & Zemel, M. B. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803294 · Cited by 46 · see citing works
Synthetic Studies of α-Tocopherol. I. Synthesis of α-Tocopheryl Acetate
Ichikawa, T., & Kato, T. (1968) · Bulletin of the Chemical Society of Japan · doi:10.1246/bcsj.41.1224 · Cited by 19 · see citing works
Reduced muscle lactate during prolonged exercise following induced plasma volume expansion
Green, H. J., Grant, S., Phillips, S. M., et al. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y97-165 · Cited by 7 · see citing works
Synthesis of α-tocopherol and naphthotocopherol analogs with a carboxyl group in the side chain
Spivak, A. Y., Knyshenko, O. V., Mallyabaeva, M. I., et al. (2006) · Russian Chemical Bulletin · doi:10.1007/s11172-006-0253-8 · Cited by 3 · see citing works
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Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
Amorim, J. A., Coppotelli, G., Rolo, A. P., Palmeira, C. M., Ross, J. M., & Sinclair, D. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00626-7 · Cited by 990 · see citing works
- Authors
- Mao, G., Kraus, G. A., Kim, I., Spurlock, M. E., Bailey, T. B., Zhang, Q., & Beitz, D. C.
- Affiliations
- Iowa State University (US)
- Corresponding author
- Beitz, Donald C.
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 140
- Issue
- 8
- Pages
- 1425-1431
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2145054353
- Cited by
- 48
- References
- 31
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 4 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- hepatic oxidative stress, fat deposition, obesity, aconitase inhibition, high-fat diet, liver mitochondria, hydrogen peroxide production, protein carbonylation, CPT1A, UCP2, acetyl-CoA carboxylase, fatty acid synthase, adipose tissue, hepatic lipid metabolism
- MeSH terms
- Aconitate Hydratase, Adenosine Triphosphate, Adipose Tissue, Animals, Body Composition, Body Weight, Diet, Dietary Fats, Eating, Hydrogen Peroxide, Lipids, Liver, Male, Mice, Inbred C57BL, Mitochondria, Liver, Mitochondria, Muscle, Obesity, Organ Size, Organophosphorus Compounds, RNA, Messenger, Ubiquinone, Gene Expression, Oxidative Stress, Muscle, Skeletal, Mice, Fatty Acid Synthases
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