Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 62

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet

Deminice, Rafael, da Silva, Robin P., Lamarre, Simon G., Brown, Colin, Furey, George N., McCarter, Shannon A., Jordao, Alceu Afonso, Kelly, Karen B., King-Jones, Kirst, Jacobs, Renaé L., Brosnan, Margaret E., Brosnan, John T.·2011·The Journal of Nutrition

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.3945/jn.111.144857

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 3 references

Research works printed but not linked: 32

  1. Adams, 2005, Recent concepts in non-alcoholic fatty liver disease., Diabet Med., 22, 1129, 10.1111/j.1464-5491.2005.01748.x · DOI · Paper page
  2. Duvnjak, 2007, Pathogenesis and management issues for non-alcoholic fatty liver disease., World J Gastroenterol., 13, 4539, 10.3748/wjg.v13.i34.4539 · DOI · Paper page
  3. Kwon, 2009, Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats., J Nutr., 139, 63, 10.3945/jn.108.094771 · DOI
  4. Day, 1998, Steatohepatitis: a tale of two "hits"?, Gastroenterology., 114, 842, 10.1016/S0016-5085(98)70599-2 · DOI · Paper page
  5. Kim, 2003, Effect of acute betaine administration on hepatic metabolism of S-amino acids in rats and mice., Biochem Pharmacol., 65, 1565, 10.1016/S0006-2952(03)00115-1 · DOI
  6. Kim, 2005, Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice., J Hepatol., 42, 907, 10.1016/j.jhep.2005.01.017 · DOI
  7. Erman, 2004, Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication., Amino Acids., 27, 199, 10.1007/s00726-004-0105-5 · DOI
  8. Edison, 2007, Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo., Am J Physiol Renal Physiol., 293, F1799, 10.1152/ajprenal.00356.2007 · DOI
  9. Deminice, 2009, Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats., Br J Nutr., 102, 110, 10.1017/S0007114508162985 · DOI
  10. Stead, 2001, Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate., Am J Physiol Endocrinol Metab., 281, E1095, 10.1152/ajpendo.2001.281.5.E1095 · DOI
  11. Lieber, 2004, Model of nonalcoholic steatohepatitis., Am J Clin Nutr., 79, 502, 10.1093/ajcn/79.3.502 · DOI · Paper page
  12. Jacobs, 2008, Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein., J Biol Chem., 283, 2147, 10.1074/jbc.M706628200 · DOI · Paper page
  13. Buchberger, 2004, Improved high-performance liquid chromatographic determination of guanidino compounds by precolumn derivatization with ninhydrin and fluorescence detection., J Sep Sci., 27, 1309, 10.1002/jssc.200401866 · DOI
  14. Vester, 1991, High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum., Eur J Clin Chem Clin Biochem., 29, 549
  15. Van Pilsum, 1970, Simplified assay for transamidinase activities of rat kidney homogenates., Anal Biochem., 35, 277, 10.1016/0003-2697(70)90035-7 · DOI
  16. Schreurs, 2010, Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome., Obes Rev., 11, 380, 10.1111/j.1467-789X.2009.00642.x · DOI · Paper page
  17. Koonen, 2007, Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity., Diabetes., 56, 2863, 10.2337/db07-0907 · DOI · Paper page
  18. Kim, 2008, Kwon do Y, Kim YC. Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation., Biochem Biophys Res Commun., 368, 893, 10.1016/j.bbrc.2008.02.003 · DOI
  19. Kharbanda, 2007, Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway., J Hepatol., 46, 314, 10.1016/j.jhep.2006.08.024 · DOI
  20. Balkan, 2004, The effect of betaine treatment on triglyceride levels and oxidative stress in the liver of ethanol-treated guinea pigs., Exp Toxicol Pathol., 55, 505, 10.1078/0940-2993-00347 · DOI
  21. Jacobs, 2010, Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity., J Biol Chem., 285, 22403, 10.1074/jbc.M110.108514 · DOI
  22. Jacobs, 2004, Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins., J Biol Chem., 279, 47402, 10.1074/jbc.M404027200 · DOI
  23. Li, 2006, The ratio of phosphatidylcholine to phosphatidylethanolaine influences membrane integrity and steatohepatitis., Cell Metab., 3, 321, 10.1016/j.cmet.2006.03.007 · DOI · Paper page
  24. Noga, 2003, Plasma homocysteine is regulated by phospholipid methylation., J Biol Chem., 278, 5952, 10.1074/jbc.M212194200 · DOI
  25. Abdelmegeed, 2011, PPAR&alpha expression protects male mice from high fat-induced nonalcoholic fatty liver., J Nutr., 141, 603, 10.3945/jn.110.135210 · DOI
  26. Brady, 1989, Co-ordinate induction of hepatic mitochondrial and peroxisomal carnitine acyltransferase synthesis by diet and drugs., Biochem J., 260, 93, 10.1042/bj2600093 · DOI
  27. Ferraé, 2004, The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity., Diabetes., 53, S43, 10.2337/diabetes.53.2007.S43 · DOI · Paper page
  28. Frier, 2011, Interactions between the consumption of a high-fat diet and fasting in the regulation of fatty acid oxidation enzyme gene expression: an evaluation of potential mechanisms., Am J Physiol Regul Integr Comp Physiol., 300, R212, 10.1152/ajpregu.00367.2010 · DOI
  29. Stienstra, 2007, Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation., Endocrinology., 148, 2753, 10.1210/en.2007-0014 · DOI
  30. Barr, 2010, Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease., J Proteome Res., 9, 4501, 10.1021/pr1002593 · DOI
  31. Aoyama, 1998, Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)., J Biol Chem., 273, 5678, 10.1074/jbc.273.10.5678 · DOI · Paper page
  32. Hultman, 1996, Muscle creatine loading in men., J Appl Physiol., 81, 232, 10.1152/jappl.1996.81.1.232 · DOI · Paper page

Cited by

See all 62

Metadata

Authors
Deminice, R., da Silva, R. P., Lamarre, S. G., Brown, C., Furey, G. N., McCarter, S. A., Jordao, A. A., Kelly, K. B., King-Jones, K., Jacobs, R. L., Brosnan, M. E., & Brosnan, J. T.
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2011-10
Volume
141
Issue
10
Pages
1799-1804
ISSN
0022-3166
Cited by
62
References
3
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. https://app.cochat.ai/papers/10.3945/jn.111.144857
The paper
Deminice, R., da Silva, R. P., Lamarre, S. G., Brown, C., Furey, G. N., McCarter, S. A., Jordao, A. A., Kelly, K. B., King-Jones, K., Jacobs, R. L., Brosnan, M. E., & Brosnan, J. T. (2011). Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. The Journal of Nutrition. https://doi.org/10.3945/jn.111.144857

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.