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Cited by 433Food Nutrient Composition and Product DevelopmentAnimal Nutrition and PhysiologyMuscle metabolism and nutrition

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Protein Digestibility-Corrected Amino Acid Scores and Digestible Indispensable Amino Acid Scores Differentially Describe Protein Quality in Growing Male Rats

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Rutherfurd, Shane M, Fanning, Aaron C, Miller, Bruce J, Moughan, Paul J·2015·The Journal of Nutrition
DOI 10.3945/jn.114.195438
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Abstract

Background The FAO has recommended replacing the protein digestibility-corrected amino acid score (PDCAAS) with the digestible indispensable amino acid score (DIAAS).Objective The objective of this study was to compare aspects underlying the calculation of the DIAAS and PDCAAS, including 1) fecal digestibility vs. ileal digestibility, 2) using a single nitrogen digestibility value for all amino acids, and 3) the effect of truncation. Truncated PDCAAS and untruncated DIAAS values calculated as formally defined were also compared and DIAAS data presented for 14 dietary protein sources.Methods Semisynthetic wheat starch-based diets were formulated to contain the test protein (as consumed by humans) source (whey- and soy-protein isolates, milk-, whey-, rice- and pea- protein concentrates, cooked kidney beans, roasted peanuts, cooked peas, corn-based breakfast cereal, cooked rice, cooked rolled oats, and wheat bran) as the sole nitrogen source and with an indigestible marker (titanium dioxide). Growing male rats (∼250 g bodyweight) were given a basal casein-based diet from day 1 to day 7 and then allocated (n = 6) to the test diets for day 8 to day 14 before ileal digesta were collected after the rats were killed. Total feces were collected from day 11 to day 14.Results True fecal nitrogen digestibility was different (P < 0.05; 10% difference on average) from true ileal nitrogen digestibility for 11 of the 14 protein sources. True ileal nitrogen digestibility was different (P < 0.05) from true ileal amino acid digestibility for almost half of the indispensable and conditionally indispensable amino acids (differences ranged from 0.9% to 400%). DIAAS values ranged from 0.01 for a corn-based cereal to 1.18 for milk protein concentrate.Conclusion Untruncated PDCAAS values were generally higher than a DIAAS values, especially for the poorer quality proteins; therefore, the reported differences in the scores are of potential practical importance for populations in which dietary protein intake may be marginal.

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  1. Fenwick, 1995, Protein quality measurement by the PDCAAS technique, Int Dairy Fed Nutr Newslett, 4, 40

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Metadata

Authors
Rutherfurd, S. M., Fanning, A. C., Miller, B. J., & Moughan, P. J.
Affiliations
  • Riddet Institute (NZ)
  • Fonterra (New Zealand) (NZ)
Corresponding author
Rutherfurd, Shane M
ORCID
Venue
The Journal of Nutrition
Publisher
Elsevier BV
Published
2015-02
Volume
145
Issue
2
Pages
372-379
ISSN
0022-3166 (ISSN-L)
DOI
10.3945/jn.114.195438
OpenAlex
W2171412593
Cited by
433
References
21
Citations by year
2026: 47 · 2025: 37 · 2024: 51 · 2023: 38 · 2022: 47 · 2021: 59 · 2020: 40 · 2019: 45 · 2018: 21 · 2017: 27 · 2016: 18 · 2015: 3
FWCI
22.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
New Zealand Government
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
protein quality, PDCAAS, DIAAS, amino acid digestibility, truncation, dietary protein source, whey protein isolate, soy protein isolate, milk protein concentrate, pea protein concentrate, rice protein concentrate, casein, growing rats
MeSH terms
Amino Acids, Amino Acids, Essential, Animals, Edible Grain, Zea mays, Cross-Sectional Studies, Dietary Proteins, Digestion, Feces, Food Analysis, Ileum, Fabaceae, Male, Milk, Nitrogen, Oryza, Triticum, Rats, Sprague-Dawley, Rats

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