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Cited by 189Animal Nutrition and PhysiologyMuscle metabolism and nutritionFood and Agricultural Sciences

Comparison of the ileal and faecal digestibility of dietary amino acids in adult humans and evaluation of the pig as a model animal for digestion studies in man

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Rowan, Angela M., Moughan, P. J., Wilson, M. N., Maher, K., Tasman-Jones, C.·1994·British Journal of Nutrition
DOI 10.1079/bjn19940108
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Abstract

The aim of the study was to determine if there is a difference between ileal and faecal assays for determining amino acid and N digestibilities in adult human subjects. Comparison of true ileal amino acid and N digestibilities was also made between adult human subjects and growing pigs to establish the usefulness of the pig as a model animal. Five subjects with established ileostomies and six subjects with intact large bowels consumed a constant diet consisting of meat, vegetables, fruit, bread and dairy products for 7 d with collection of ileostomy contents or faeces respectively over the last 4 d. The study was repeated using 25 kg body weight ileostomized and intact pigs. Apparent amino acid and N digestibility coefficients were determined. For human subjects the faecal digestibility values were significantly higher (P< 0·05) than the ileal values for Arg, Asp, Gly, Phe, Pro, Ser, Thr and Trp. The faecal digestibility of Met was significantly lower than the ileal value. Determination of DNA, diaminopimelic acid (DAPA) and the digestibilities of pectin, hemicellulose and cellulose in human subjects indicated that some microbial colonization had occurred at the terminal ileum after formation of an ileostomy; however, this was not as extensive as in the large intestine. True ileal amino acid and N digestibilities were calculated after correcting for the endogenous contribution of amino acids at the terminal ileum determined using a protein-free diet. There were no significant differences between adult human subjects and pigs for true ileal dietary amino acid digestibility except for Thr, Phe, Cys and Met. There were no significant differences between adult humans and pigs for the ileal digestibility of dry matter and the faecal digestibility of gross energy.

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  2. Dodds, W. J. (1982). The pig model for biomedical research. Federation Proceedings 41, 247-256.
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  4. Inc. through the human small intestine. Gastroenterology 49, 58-66. ileostomates. Proceedings qf the Nutrition Society 49, 1 IOA. https://doi.org/10.1079/BJN19940108 Published online by Cambridge University Press · DOI
  5. Moughan, P. J. & Rowan, A. M. (1989). The pig as a model animal for human nutrition research. Proceedings
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  7. R. M. Batt and T. L. J. Lawrence, editors]. Liverpool: Liverpool University Press.
  8. Rowan, A. M. (1989). A study of the digestion of protein in humans using ileal and faecal assays. MSc Thesis, Massey University, Palmerston North, New Zealand.
  9. Rowan, A. M., Moughan, P. J. & Wilson, M. N. (1989). Alkaline hydrolysis for the determination of tryptophan in biological samples. Proceedings of the Nutrition Society of New Zealand 14, 169-1 72.
  10. Russell, C. A., Evans, S. J. & Mabbutt, C. (1984). A comparison of the absorption of nitrogen from ''chemically- defined elemental " or "whole-protein" enteral feeds by the human small bowel. Proceedings of the Nutrition Society 43, 123A.
  11. Sandstrom, B., Anderson, H., Kivisto, B. & Sandberg, A. S. (1986). Apparent small intestinal absorption of nitrogen and minerals from soy and meat-protein based diets. Journal of Nutrition 116, 2209-221 8. of the Nutrition Society of New Zealand 14, 116-124.
  12. London: H M Stationery Office. of amino acids. Federation Proceedings 27, 1 199-1 203. https://doi.org/10.1079/BJN19940108 Published online by Cambridge University Press · DOI
  13. Southgate, D. A. T. (1981). In The Analysis of'Dierary Fibre in Foods, pp. 1-21 [
  14. Zebrowska, T. (1973). Influence of dietary protein source on the rate of digestion in the small intestine of pigs. Part 11. The rate of protein digestion and amino acid absorption. Roczniki Nauk Rolniczych B 95, 135-155. Printed in Great Britain https://doi.org/10.1079/BJN19940108 Published online by Cambridge University Press

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Authors
Rowan, A. M., Moughan, P. J., Wilson, M. N., Maher, K., & Tasman-Jones, C.
Affiliations
  • Massey University (NZ)
  • University of Auckland (NZ)
ORCID
Moughan, P. J.
Venue
British Journal of Nutrition
Publisher
Cambridge University Press (CUP)
Published
1994-01
Volume
71
Issue
1
Pages
29-42
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1079/bjn19940108
OpenAlex
W1983871291
Cited by
189
References
49
Citations by year
2026: 7 · 2025: 10 · 2024: 9 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 11 · 2019: 11 · 2018: 8 · 2017: 7 · 2016: 3 · 2015: 1 · 2014: 7 · 2013: 12 · 2012: 14
FWCI
8.14
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 4815 d)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
Keywords
ileal digestibility, faecal digestibility, nitrogen digestibility, ileostomy, endogenous amino acids, gross energy digestibility
MeSH terms
Adult, Aged, Amino Acids, Animals, Diet, Dietary Fiber, Digestion, DNA, Evaluation Studies as Topic, Feces, Female, Humans, Ileostomy, Ileum, Male, Middle Aged, Models, Biological, Nitrogen, Swine

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