Cited by 229Probiotics and Fermented FoodsGut microbiota and healthMicrobial Metabolites in Food Biotechnology

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Modulation of Fecal Clostridiales Bacteria and Butyrate by Probiotic Intervention with Lactobacillus paracasei DG Varies among Healthy Adults

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Ferrario, Chiara, Taverniti, Valentina, Milani, Christian, Fiore, Walter, Laureati, Monica, De Noni, Ivano, Stuknyte, Milda, Chouaia, Bessem, Riso, Patrizia, Guglielmetti, Simone·2014·The Journal of Nutrition

DOI 10.3945/jn.114.197723

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Abstract

Background The modulation of gut microbiota is considered to be the first target to establish probiotic efficacy in a healthy population.Objective This study was conducted to determine the impact of a probiotic on the intestinal microbial ecology of healthy volunteers.Methods High-throughput 16S ribosomal RNA gene sequencing was used to characterize the fecal microbiota in healthy adults (23-55 y old) of both sexes, before and after 4 wk of daily consumption of a capsule containing at least 24 billion viable Lactobacillus paracasei DG cells, according to a randomized, double-blind, crossover placebo-controlled design.Results Probiotic intake induced an increase in Proteobacteria (P = 0.006) and in the Clostridiales genus Coprococcus (P = 0.009), whereas the Clostridiales genus Blautia (P = 0.036) was decreased; a trend of reduction was also observed for Anaerostipes (P = 0.05) and Clostridium (P = 0.06). We also found that the probiotic effect depended on the initial butyrate concentration. In fact, participants with butyrate >100 mmol/kg of wet feces had a mean butyrate reduction of 49 ± 21% and a concomitant decrease in the sum of 6 Clostridiales genera, namely Faecalibacterium, Blautia, Anaerostipes, Pseudobutyrivibrio, Clostridium, and Butyrivibrio (P = 0.021), after the probiotic intervention. In contrast, in participants with initial butyrate concentrations <25 mmol/kg of wet feces, the probiotic contributed to a 329 ± 255% (mean ± SD) increment in butyrate concomitantly with an ∼55% decrease in Ruminococcus (P = 0.016) and a 150% increase in an abundantly represented unclassified Bacteroidales genus (P = 0.05).Conclusions The intake of L. paracasei DG increased the Blautia:Coprococcus ratio, which, according to the literature, can potentially confer a health benefit on the host. The probiotic impact on the microbiota and on short-chain fatty acids, however, seems to strictly depend on the initial characteristics of the intestinal microbial ecosystem. In particular, fecal butyrate concentrations could represent an important biomarker for identifying subjects who may benefit from probiotic treatment. This trial was registered at www.controlled-trials.com/isrctn as ISRCTN56945491.

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Authors: Ferrario, C., Taverniti, V., Milani, C., Fiore, W., Laureati, M., De Noni, I., Stuknyte, M., Chouaia, B., Riso, P., & Guglielmetti, S.
Affiliations: University of Milan (IT)
University of Parma (IT)
Sofar (Italy) (IT)
Corresponding author: Guglielmetti, Simone
ORCID: Ferrario, Chiara
Taverniti, Valentina
Milani, Christian
Fiore, Walter
Laureati, Monica
Chouaia, Bessem
Riso, Patrizia
Guglielmetti, Simone
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2014-11
Volume: 144
Issue: 11
Pages: 1787-1796
ISSN: 0022-3166 (ISSN-L)
DOI: 10.3945/jn.114.197723
OpenAlex: W2162642016
Cited by: 228
References: 48
Citations by year: 2026: 7 · 2025: 18 · 2024: 19 · 2023: 14 · 2022: 35 · 2021: 40 · 2020: 22 · 2019: 19 · 2018: 18 · 2017: 12 · 2016: 13 · 2015: 11
FWCI: 17.20
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3010 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, cc-by-nc)
BOA (University of Milano-Bicocca) (submittedVersion, other-oa)
ARCA (Università Ca' Foscari Venezia) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, fecal microbiota, Clostridiales, butyrate, short-chain fatty acids, Proteobacteria, Ruminococcus, Faecalibacterium, Bacteroidales, healthy adults, gut microbiota modulation, 16S rRNA gene sequencing
MeSH terms: Adult, Double-Blind Method, Feces, Female, Humans, Lactobacillus, Male, Middle Aged, Gram-Positive Endospore-Forming Rods, Probiotics, Butyric Acid, Young Adult

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Modulation of Fecal Clostridiales Bacteria and Butyrate by Probiotic Intervention with Lactobacillus paracasei DG Varies among Healthy Adults

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