Physician's guide to popular low-carbohydrate weight-loss diets.

Blackburn, G L; Phillips, J C; Morreale, S

doi:10.3949/ccjm.68.9.761

Cited by 60Diet and metabolism studiesDietary Effects on HealthBariatric Surgery and Outcomes

Physician's guide to popular low-carbohydrate weight-loss diets.

Blackburn, G L, Phillips, J C, Morreale, S·2001·Cleveland Clinic Journal of Medicine

DOI 10.3949/ccjm.68.9.761

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Abstract

Low-carbohydrate weight-loss diets are very popular, but the recommendations of many of these diets are diametrically opposed to those put forth by the US Department of Agriculture, the American Heart Association, and other national organizations. Their focus on foods high in protein, fat, and cholesterol has potentially serious health implications. Physicians need to be knowledgeable about the efficacy of these programs and to talk to overweight patients about weight loss.

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Blood concentrations of LDL-cholesterol are expected to decrease with moderate weight loss.
“Blood concentrations of LDL-cholesterol are expected to decrease with moderate weight loss (44)”
From Effects of low-carbohydrate diets<i>v</i>. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials (2016) · cites this paper as [44]

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Low-Carbohydrate High-Fat (LCHF) Diet: Evidence of Its Benefits
De, P., & Mukhopadhyay, S. (2018) · InTech eBooks · doi:10.5772/intechopen.73138 · Cited by 2 · see citing works
Effects of Low-Carbohydrate, High-Fat Diets on Weight Loss, Cardiovascular Health and Mortality
Kim, B. (2020) · Cardiovascular Prevention and Pharmacotherapy · doi:10.36011/cpp.2020.2.e7 · Cited by 2 · see citing works
The ketogenic diet in health and disease
Rajiyah, T., & Pannain, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00025-1 · Cited by 1 · see citing works
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Hyperuricemia, Gout, and Diet
Schlesinger, N. (2008) · Nutrition and Health · doi:10.1007/978-1-59745-403-2_10 · Cited by 1 · see citing works
The obesogenic effects of high-fat diets are influenced by both protein source and amount
Bjelland, S. (2013) · NORA - Norwegian Open Research Archives
The Low-Carbohydrate Diet as an Effective Measure to Achieve Significant Weight Loss and Improve Parameters of Cardiovascular Disease
Mansoor, N. (2014) · NORA - Norwegian Open Research Archives
Reduction: A Randomized Trial and Zone Diets for Weight Loss and Heart Disease Risk Comparison of the Atkins, Ornish, Weight Watchers,
Eckel, R. H., Dansinger, M. L., & Ornish, D. M. (2010)
Nonpharmacologic Treatment of Gout
Schlesinger, N. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54823-6.00013-0
Body Composition
Carr, T. P. (2002) · doi:10.1002/9780470693759.ch8
Weight Loss Study: A Randomized Trial Among Overweight Premenopausal Women: The A TO Z Diets for Change in Weight and Related Risk Factors Comparison of the Atkins, Zone, Ornish, and LEARN
Latner, J. D. (2010)
Foetal Starvation, Economic Adversity and Health a Difference-in-Difference Approach
Husain, Z., Mukherjee, D., Dutta, M., & Mukhopadhyay, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-9981-7_20
Weight Control: Challenges and Solutions
Spark, A., Dinour, L. M., & Obenchain, J. (2015) · CRC Press eBooks · doi:10.1201/b19301-10
Nutrition
Burd, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-28683-1.00032-1
Weight Control
(2007) · CRC Press eBooks · doi:10.1201/9780203507889.ch7

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Obesity among Saudi children
Shehri, A. A., Alwan, I. A. A., & Fattani, A. A. (2013) · Saudi Journal of Obesity · doi:10.4103/wkmp-0035.119467 · Cited by 8 · see citing works
Occurrence of overweight and obesity among adult rural population in Eastern Poland. Relationship between obesity and selected socio-economic factors.
Panasiuk, L., Wdowiak, L., Paprzycki, P., et al. (2008) · PubMed · Cited by 15 · see citing works
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Singh, S., Somers, V. K., Clark, M. M., Vickers, K. S., Hensrud, D. D., Korenfeld, Y., & López-Jiménez, F. A. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.07.023 · Cited by 36 · see citing works
Expanding the Limits of Treatment—New Strategic Initiatives
Blackburn, G. L., & Waltman, B. A. (2005) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2005.02.019 · Cited by 17 · see citing works
Self-citation

Authors: Blackburn, G. L., Phillips, J. C., & Morreale, S.
Affiliations: Harvard University (US)
Venue: Cleveland Clinic Journal of Medicine
Publisher: Cleveland Clinic Journal of Medicine
Published: 2001-09-01
Volume: 68
Issue: 9
Pages: 761-761
ISSN: 0891-1150 (ISSN-L)
1939-2869
DOI: 10.3949/ccjm.68.9.761
OpenAlex: W2037084925
Cited by: 60
References: 0
Citations by year: 2024: 1 · 2020: 7 · 2019: 4 · 2018: 3 · 2017: 3 · 2015: 3 · 2014: 3 · 2013: 5
FWCI: 2.99
Type: journal article
Language: en
Open access: closed
Locations: Cleveland Clinic Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Diet and metabolism studies
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords: low-carbohydrate diet, weight loss diet, obesity, overweight patients, dietary recommendations, protein intake, dietary cholesterol, dietary fat, physician counseling
MeSH terms: Diet Fads, Dietary Carbohydrates, Humans, Obesity, Weight Loss, Practice Guidelines as Topic

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Physician's guide to popular low-carbohydrate weight-loss diets.

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