A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men

Sharman, Matthew J.; Kraemer, William J.; Love, Dawn M.; Avery, Neva G.; Gómez, Ana L.; Scheett, Timothy P.; Volek, Jeff S.

doi:10.1093/jn/132.7.1879

Cited by 312Diet and metabolism studiesDietary Effects on HealthNutritional Studies and Diet

A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men

Open access

Sharman, Matthew J., Kraemer, William J., Love, Dawn M., Avery, Neva G., Gómez, Ana L., Scheett, Timothy P., Volek, Jeff S.·2002·The Journal of Nutrition

DOI 10.1093/jn/132.7.1879

Open this paper in CoChat — free account Open PDF

Abstract

Very low-carbohydrate (ketogenic) diets are popular yet little is known regarding the effects on serum biomarkers for cardiovascular disease (CVD). This study examined the effects of a 6-wk ketogenic diet on fasting and postprandial serum biomarkers in 20 normal-weight, normolipidemic men. Twelve men switched from their habitual diet (17% protein, 47% carbohydrate and 32% fat) to a ketogenic diet (30% protein, 8% carbohydrate and 61% fat) and eight control subjects consumed their habitual diet for 6 wk. Fasting blood lipids, insulin, LDL particle size, oxidized LDL and postprandial triacylglycerol (TAG) and insulin responses to a fat-rich meal were determined before and after treatment. There were significant decreases in fasting serum TAG (-33%), postprandial lipemia after a fat-rich meal (-29%), and fasting serum insulin concentrations (-34%) after men consumed the ketogenic diet. Fasting serum total and LDL cholesterol and oxidized LDL were unaffected and HDL cholesterol tended to increase with the ketogenic diet (+11.5%; P = 0.066). In subjects with a predominance of small LDL particles pattern B, there were significant increases in mean and peak LDL particle diameter and the percentage of LDL-1 after the ketogenic diet. There were no significant changes in blood lipids in the control group. To our knowledge this is the first study to document the effects of a ketogenic diet on fasting and postprandial CVD biomarkers independent of weight loss. The results suggest that a short-term ketogenic diet does not have a deleterious effect on CVD risk profile and may improve the lipid disorders characteristic of atherogenic dyslipidemia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1093/jn/132.7.1879

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Increases in LDL cholesterol and decreases in triglycerides are common effects of low-carb diets, and have been linked with a shift in the LDL cholesterol particle size that is associated with a decreased cardiovascular risk.
“Increases in LDL cholesterol and decreases in triglycerides are common effects of low-carb diets, and have been linked with a shift in the LDL cholesterol particle size that is associated with a decreased cardiovascular risk (45–48).”
From Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: the Interventional Keto-Med Randomized Crossover Trial. (2022) · cites this paper as [45]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502 · see citing works
Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction
Austin, M. A. (1988) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1988.03410130125037 · Cited by 1,780 · see citing works
Low Density Lipoprotein Oxidation and Its Pathobiological Significance
Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,643 · see citing works
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411 · see citing works
Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state
Patsch, J. R., Miesenböck, G., Hopferwieser, T., Mühlberger, V, Knapp, E., Dunn, J. K., Gotto, A. M., & Patsch, W. (1992) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.12.11.1336 · Cited by 1,122 · see citing works
Hypertriglyceridemia as a cardiovascular risk factor
Austin, M. A., Hokanson, J. E., & Edwards, K. L. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00031-9 · Cited by 1,066 · see citing works
Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis
Dattilo, A., & Kris-Etherton, P. (1992) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.2.320 · Cited by 1,055 · see citing works
Enhanced susceptibility to in vitro oxidation of the dense low density lipoprotein subfraction in healthy subjects.
Graaf, J. D., Hak-Lemmers, H. L. M., Hectors, M. P. C., Demacker, P. N. M., Hendriks, J. C. M., & Stalenhoef, A. F. H. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.2.298 · Cited by 714 · see citing works
Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms
Parks, E. J., & Hellerstein, M. K. (2000) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.412 · Cited by 530 · see citing works
Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) subfractions: relative contribution of small, dense LDL to coronary heart disease risk
Griffin, B. A., Freeman, D. J., Tait, G. W., Thomson, J., Caslake, M. J., Packard, C. J., & Shepherd, J. (1994) · Atherosclerosis · doi:10.1016/0021-9150(94)90129-5 · Cited by 525 · see citing works
The human metabolic response to chronic ketosis without caloric restriction: Preservation of submaximal exercise capability with reduced carbohydrate oxidation
Phinney, S. D., Bistrian, B. R., Evans, W. J., Gervino, E., & Blackburn, G. L. (1983) · Metabolism · doi:10.1016/0026-0495(83)90106-3 · Cited by 422 · see citing works
Oxygen-mediated heterogeneity of apo-low-density lipoprotein.
Schuh, J., Fairclough, G. F., & Haschemeyer, R. H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3173 · Cited by 271 · see citing works
Development of a Rapid, Quantitative Method for LDL Subfractionation with Use of the Quantimetrix Lipoprint LDL System
Hoefner, D. M., Hodel, S. D., O’Brien, J. F., Branum, E. L., Sun, D. H., Meissner, I., & McConnell, J. P. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.2.266 · Cited by 266 · see citing works
The Soft Science of Dietary Fat
Taubes, G. (2001) · Science · doi:10.1126/science.291.5513.2536 · Cited by 259 · see citing works
The effect of different diets and of insulin on the hormonal response to prolonged exercise
Galbo, H., Holst, J. J., & Christensen, N. J. (1979) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1979.tb06438.x · Cited by 252 · see citing works
Low‐density lipoprotein subclass patterns and lipoprotein response to a reduced‐fat diet in men
Dreon, D. M., Fernstrom, H. A., Miller, B., & Krauss, R. M. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.1.8299884 · Cited by 196 · see citing works
Dietary fat content alters insulin-mediated glucose metabolism in healthy men
Bisschop, P. H. L. T., de Metz, J., Ackermans, M. T., Endert, E., Pijl, H., Kuipers, F., Meijer, A. J., Sauerwein, H. P., & Romijn, J. A. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.3.554 · Cited by 163 · see citing works
A very-low-fat diet is not associated with improved lipoprotein profiles in men with a predominance of large, low-density lipoproteins
Dreon, D. M., Fernstrom, H. A., Williams, P. T., & Krauss, R. M. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.3.411 · Cited by 149 · see citing works
Lipoprotein lipase activity and intramuscular triglyceride stores after long‐term high‐fat and high‐carbohydrate diets in physically trained men
Kiens, B., Essén-Gustavsson, B., Gad, P., & Lithell, H. (1987) · Clinical Physiology · doi:10.1111/j.1475-097x.1987.tb00628.x · Cited by 134 · see citing works
Associations of hepatic and lipoprotein lipase activities with changes in dietary composition and low density lipoprotein subclasses.
Campos, H., Dreon, D. M., & Krauss, R. M. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39880-1 · Cited by 121 · see citing works
Why Do Low-Fat High-Carbohydrate Diets Accentuate Postprandial Lipemia in Patients With NIDDM?
Chen, Y. I., Coulston, A. M., Zhou, M., Hollenbeck, C. B., & Reaven, G. M. (1995) · Diabetes Care · doi:10.2337/diacare.18.1.10 · Cited by 120 · see citing works
Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight
LAROSA, J. C., FRY, A. G., MUESING, R., & ROSING, D. R. (1980) · Journal of the American Dietetic Association · doi:10.1016/s1094-7159(21)03514-5 · Cited by 116 · see citing works
The Impact of Postprandial Lipemia in Accelerating Atherothrombosis
Roche, H. M., & Gibney, M. J. (2000) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1177/204748730000700504 · Cited by 110 · see citing works
Investigation of low density lipoprotein subfractions as a coronary risk factor in normotriglyceridaemic men
Rajman, I., Kendall, M. J., Cramb, R., Holder, R. L., Salih, M., & GAMMAGE, M. D. (1996) · Atherosclerosis · doi:10.1016/0021-9150(96)05881-9 · Cited by 108 · see citing works
Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions
Krauss, R. M. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.340s · Cited by 101 · see citing works
Insulin Stimulation of Hepatic Triacylglycerol Secretion and the Etiology of Insulin Resistance
Zammit, V. A., Waterman, I. J., McKay, G. A., & Topping, D. L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2074 · Cited by 99 · see citing works
The genetics of serum lipid responsiveness to dietary interventions
Ordovás, J. M. (1999) · Proceedings of The Nutrition Society · doi:10.1079/pns19990023 · Cited by 95 · see citing works
U-shape relationship between change in dietary cholesterol absorptionand plasma lipoprotein responsiveness and evidence for extreme interindividualvariation in dietary cholesterol absorption in humans
Sehayek, E., Nath, C., Heinemann, T., McGee, M., Seidman, C. E., Samuel, P., & Breslow, J. L. (1998) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33320-4 · Cited by 87 · see citing works
Fasting Lipoprotein and Postprandial Triacylglycerol Responses to a Low-Carbohydrate Diet Supplemented with n-3 Fatty Acids
Volek, J. S., Gómez, A. L., & Kraemer, W. J. (2000) · Journal of the American College of Nutrition · doi:10.1080/07315724.2000.10718935 · Cited by 84 · see citing works
Self-citation
Diet and syndrome X
Reaven, G. M. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0050-z · Cited by 83 · see citing works
The effect of a low-carbohydrate diet on performance, hormonal and metabolic responses to a 30-s bout of supramaximal exercise
Langfort, J., Zarzeczny, R., Pilis, W., Nazar, K., & Kaciuba-Uściłko, H. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050224 · Cited by 67 · see citing works
Effect of low-carbohydrate-ketogenic diet on metabolic and hormonal responses to graded exercise in men.
Langfort, J., Pilis, W., Zarzeczny, R., Nazar, K., & Kaciuba-Uściłko, H. (1996) · PubMed · Cited by 64 · see citing works
Effects of a high-fat diet on postabsorptive and postprandial testosterone responses to a fat-rich meal
Volek, J. S., mez, A. L. G., Love, D. M., Avery, N. G., Sharman, M. J., & Kraemer, W. J. (2001) · Metabolism · doi:10.1053/meta.2001.25648 · Cited by 61 · see citing works
Self-citation
Physician's guide to popular low-carbohydrate weight-loss diets.
Blackburn, G. L., Phillips, J. C., & Morreale, S. (2001) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.68.9.761 · Cited by 60 · see citing works
Prolactin, Growth Hormone, Thyrotropin, 3,5,3′-Triiodothyronine, and Thyroxine Responses to Exercise after Fat- and Carbohydrate-Enriched Diet*
Johannessen, A. C., Hagen, C., & Galbo, H. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-1-56 · Cited by 58 · see citing works
Postchallenge plasma lipoprotein retinoids: Chylomicron remnants in endogenous hypertriglyceridemia
Wilson, D. E., Chan, I.-F., Buchi, K. N., & Horton, S. C. (1985) · Metabolism · doi:10.1016/0026-0495(85)90193-3 · Cited by 51 · see citing works
Relationship between Post-Heparin Plasma Lipases, Triglycerides and High Density Lipoproteins in Normal Subjects
Jackson, R. L., Yates, M., McNerney, C. A., & Kashyap, M. L. (1990) · Hormone and Metabolic Research · doi:10.1055/s-2007-1004904 · Cited by 50 · see citing works
Low-carbohydrate diet alters intracellular glucose metabolism but not overall glucose disposal in exercise-trained subjects
Cutler, D. L., Gray, C. G., Park, S. W., Hickman, M. G., Bell, J., & Kolterman, O. (1995) · Metabolism · doi:10.1016/0026-0495(95)90027-6 · Cited by 39 · see citing works
Hormonal and metabolic changes induced by an isocaloric isoproteinic ketogenic diet in healthy subjects.
Féry, F., Bourdoux, P. P., Christophe, J., & BALASSE, E. O. (1982) · PubMed · Cited by 30 · see citing works
An NCEP II Diet Reduces Postprandial Triacylglycerol in Normocholesterolemic Adults
Miller, M. J., Teter, B. B., Dolinar, C., & Georgopoulos, A. (1998) · Journal of Nutrition · doi:10.1093/jn/128.3.582 · Cited by 10 · see citing works
Carbohydrate: Friend or Foe? Summary of Research Needs
Schneeman, B. O. (2001) · Journal of Nutrition · doi:10.1093/jn/131.10.2764s · Cited by 8 · see citing works
A successful dietary treatment fails to normalize plasma triglyceride postprandial response in type IV patients
Zoppo, A., Maggi, F. M., & Catapano, A. L. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00121-5 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets
Paoli, A., Rubini, A., Volek, J. S., & Grimaldi, K. A. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.116 · Cited by 885 · see citing works
Self-citation
Scientific Opinion on Dietary Reference Values for protein
EFSA Panel on Dietetic Products, N. A. A. (. (2012) · EFSA Journal · doi:10.2903/j.efsa.2012.2557 · Cited by 739 · see citing works
Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works
Efficacy and Safety of Low-Carbohydrate Diets: A Systematic Review
Bravata, D. M., Sanders, L., Huang, J., Krumholz, H. M., Olkin, I., Gardner, C. D., & Bravata, D. M. (2003) · JAMA · doi:10.1001/jama.289.14.1837 · Cited by 561 · see citing works
Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo
Brinkworth, G. D., Noakes, M., Buckley, J. D., Keogh, J. B., & Clifton, P. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27326 · Cited by 284 · see citing works
Effects of a Ketogenic Diet in Overweight Women with Polycystic Ovary Syndrome
Paoli, A., Mancin, L., Giacona, M. C., Bianco, A., & Caprio, M. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02277-0 · Cited by 281 · see citing works
Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: Time for a critical appraisal
Accurso, A., Bernstein, R. K., Dahlqvist, A., Draznin, B., Feinman, R. D., Fine, E. J., Gleed, A., Jacobs, D. B., Larson, G., Lustig, R. H., et al. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-9 · Cited by 263 · see citing works
Self-citation
Efficacy of low carbohydrate diet for type 2 diabetes mellitus management: A systematic review and meta-analysis of randomized controlled trials
Meng, Y., Bai, H., Wang, S., Li, Z., Wang, Q., & Chen, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.07.006 · Cited by 221 · see citing works
Comparison of energy-restricted very low-carbohydrate and low-fat diets on weight loss and body composition in overweight men and women
Volek, J., Sharman, M., Gómez, A., Judelson, D., Rubin, M., Watson, G., Sokmen, B., Silvestre, R., French, D., & Kraemer, W. (2004) · Nutrition & Metabolism · doi:10.1186/1743-7075-1-13 · Cited by 175 · see citing works
Self-citation
The Management of Very Low-Calorie Ketogenic Diet in Obesity Outpatient Clinic: A Practical Guide
Muscogiuri, G., Barrea, L., Laudisio, D., Pugliese, G., Salzano, C., Savastano, S., & Colao, A. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2104-z · Cited by 180 · see citing works
Very low-carbohydrate and low-fat diets affect fasting lipids and postprandial lipemia differently in overweight men
Sharman, M. J., Gómez, A. L., Kraemer, W. J., & Volek, J. S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.4.880 · Cited by 167 · see citing works
Self-citation
Modification of Lipoproteins by Very Low-Carbohydrate Diets
Volek, J. S., Sharman, M. J., & Forsythe, C. E. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.6.1339 · Cited by 159 · see citing works
Self-citation
Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults
Mohorko, N., Černelič-Bizjak, M., Poklar-Vatovec, T., Grom, G., Kenig, S., Petelin, A., & Jenko-Pražnikar, Z. (2019) · Nutrition Research · doi:10.1016/j.nutres.2018.11.007 · Cited by 147 · see citing works
Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: the Interventional Keto-Med Randomized Crossover Trial.
Gardner, C. D., Landry, M. J., Perelman, D., Petlura, C., Durand, L. R., Aronica, L., Crimarco, A., Cunanan, K. M., Chang, A., Dant, C. C., et al. (2022) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac154 · Cited by 151 · see citing works
Protein in optimal health: heart disease and type 2 diabetes
Layman, D. K., Clifton, P., Gannon, M. C., Krauss, R. M., & Nuttall, F. Q. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1571s · Cited by 142 · see citing works
A review of low-carbohydrate ketogenic diets
Westman, E. C., Mavropoulos, J., Yancy, W. S., & Volek, J. S. (2003) · Current Atherosclerosis Reports · doi:10.1007/s11883-003-0038-6 · Cited by 133 · see citing works
Self-citation
Effect of a low-carbohydrate, ketogenic diet program compared to a low-fat diet on fasting lipoprotein subclasses
Westman, E. C., Yancy, W. S., Olsen, M. K., Dudley, T., & Guyton, J. R. (2006) · International Journal of Cardiology · doi:10.1016/j.ijcard.2005.08.034 · Cited by 115 · see citing works
Effects of carbohydrate-restricted diets on low-density lipoprotein cholesterol levels in overweight and obese adults: a systematic review and meta-analysis
Gjuladin-Hellon, T., Davies, I. G., Penson, P., & Amiri Baghbadorani, R. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuy049 · Cited by 108 · see citing works
A Ketogenic Low-Carbohydrate High-Fat Diet Increases LDL Cholesterol in Healthy, Young, Normal-Weight Women: A Randomized Controlled Feeding Trial
Burén, J., Ericsson, M., Damasceno, N., & Sjödin, A. (2021) · Nutrients · doi:10.3390/nu13030814 · Cited by 104 · see citing works
Thermodynamics and Metabolic Advantage of Weight Loss Diets
Feinman, R. D., & Fine, E. J. (2003) · Metabolic Syndrome and Related Disorders · doi:10.1089/154041903322716688 · Cited by 98 · see citing works
Effects of a carbohydrate-restricted diet with and without supplemental soluble fiber on plasma low-density lipoprotein cholesterol and other clinical markers of cardiovascular risk
Wood, R. J., Fernandez, M. L., Sharman, M. J., Silvestre, R., Greene, C. M., Zern, T. L., Shrestha, S., Judelson, D. A., Gomez, A. L., Kraemer, W. J., et al. (2007) · Metabolism · doi:10.1016/j.metabol.2006.08.021 · Cited by 87 · see citing works
Self-citation
Resistance training in overweight women on a ketogenic diet conserved lean body mass while reducing body fat
Jabekk, P. T., Moe, I. A., Meen, H. D., Tomten, S. E., & Høstmark, A. T. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-17 · Cited by 85 · see citing works
Safety of low‐carbohydrate diets
Crowe, T. C. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00196.x · Cited by 82 · see citing works
Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet
Paoli, A., Moro, T., Bosco, G., Bianco, A., Grimaldi, K., Camporesi, E., & Mangar, D. (2015) · Marine Drugs · doi:10.3390/md13020996 · Cited by 81 · see citing works
Very-low-carbohydrate weight-loss diets revisited.
Volek, J. S., & Westman, E. C. (2002) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.69.11.849 · Cited by 77 · see citing works
Self-citation
Alternative Dietary Patterns for Americans: Low-Carbohydrate Diets
Volek, J. S., Phinney, S. D., Krauss, R. M., Johnson, R. J., Saslow, L. R., Gower, B., Yancy, W. S., King, J. C., Hecht, F. M., Teicholz, N., et al. (2021) · Nutrients · doi:10.3390/nu13103299 · Cited by 57 · see citing works
Self-citation
VLCKD: a real time safety study in obesity
Barrea, L., Verde, L., Vetrani, C., Marino, F., Aprano, S., Savastano, S., Colao, A., & Muscogiuri, G. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-021-03221-6 · Cited by 47 · see citing works
What is the best diet for cardiovascular wellness? A comparison of different nutritional models
Migliaccio, S., Brasacchio, C., Pivari, F., Salzano, C., Barrea, L., Muscogiuri, G., Savastano, S., Colao, A., & on behalf of Obesity Programs of nutrition, E. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0018-0 · Cited by 39 · see citing works
Comparative Evaluation of a Low-Carbohydrate Diet and a Mediterranean Diet in Overweight/Obese Patients with Type 2 Diabetes Mellitus: A 16-Week Intervention Study
Currenti, W., Losavio, F., Quiete, S., Alanazi, A. M., Messina, G., Polito, R., Ciolli, F., Zappalà, R. S., Galvano, F., & Cincione, R. I. (2023) · Nutrients · doi:10.3390/nu16010095 · Cited by 23 · see citing works
Very Low Calorie Ketogenic Diet: What Effects on Lipid Metabolism?
Suarez, R., Chapela, S., Llobera, N. D., Montalván, M., Vásquez, C. A., Martinuzzi, A. L. N., Katsanos, C. S., Verde, L., Frias-Toral, E., Barrea, L., et al. (2024) · Current Nutrition Reports · doi:10.1007/s13668-024-00556-6 · Cited by 20 · see citing works
To Err is Human: Can American Medicine Learn from Past Mistakes?
Ritterman, J. B. (2017) · The Permanente Journal · doi:10.7812/tpp/16-181 · Cited by 14 · see citing works

Short Report: Treatment In children using intensive insulin therapy, a 20-g variation in carbohydrate amount significantly impacts on postprandial glycaemia
Smart, C. E., King, B. R., McElduff, P., et al. (2012)
Exercise prevents the augmentation of postprandial lipaemia attributable to a low-fat high-carbohydrate diet
Koustsair, C., & Hardman, A. E. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001408 · Cited by 27 · see citing works
In children using intensive insulin therapy, a 20‐g variation in carbohydrate amount significantly impacts on postprandial glycaemia
Smart, C. E., King, B. R., McElduff, P., & Collins, C. E. (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03595.x · Cited by 86 · see citing works
Learning and meal-associated drinking: meal-related deficits produce adjustments in postprandial drinking.
Lucas, G. A., Timberlake, W., & Gawley, D. J. (1989) · Physiology and Behavior · doi:10.1016/0031-9384(89)90004-8 · Cited by 9 · see citing works
The Effect of Meal and Exercise Timing on Postprandial Lipemia
Kern, M., Bushnell, D., & Cheng, M. H.-Y. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000486168.31673.e1

Authors: Sharman, M. J., Kraemer, W. J., Love, D. M., Avery, N. G., Gómez, A. L., Scheett, T. P., & Volek, J. S.
Affiliations: University of Connecticut (US)
Corresponding author: Volek, Jeff S.
ORCID: Sharman, Matthew J.
Kraemer, William J.
Volek, Jeff S.
Venue: The Journal of Nutrition
Publisher: Elsevier BV
Published: 2002-07
Volume: 132
Issue: 7
Pages: 1879-1885
ISSN: 0022-3166 (ISSN-L)
DOI: 10.1093/jn/132.7.1879
OpenAlex: W2096171864
Cited by: 312
References: 43
Citations by year: 2026: 4 · 2025: 6 · 2024: 14 · 2023: 11 · 2022: 18 · 2021: 9 · 2020: 68 · 2019: 15 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 5 · 2012: 7
FWCI: 9.19
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7520 d)
Locations: Journal of Nutrition (publishedVersion)
PubMed (publishedVersion)
eCite Digital Repository (University of Tasmania) (submittedVersion)
Figshare (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Physiology › Diet and metabolism studies
Health Sciences › Medicine › Physiology › Dietary Effects on Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: ketogenic diet, very low carbohydrate diet, cardiovascular risk, serum biomarkers, postprandial lipemia, triglycerides, insulin, LDL particle size, oxidized LDL, HDL cholesterol, LDL cholesterol, atherogenic dyslipidemia, high-fat meal
MeSH terms: Adult, Body Weight, Energy Intake, Cardiovascular Diseases, Diet, Dietary Fats, Fasting, Humans, Insulin, Ketosis, Lipids, Lipoproteins, LDL, Male, Middle Aged, Reference Values, Triglycerides, Biomarkers, Postprandial Period

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A ketogenic diet favorably affects serum biomarkers for cardiovascular disease in normal-weight men

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks