COVID-19 in older adults
Open accessAbstract
The impact of COVID-19 varies by age group, and it has become clear that individuals over 65 years are disproportionately impacted by COVID-19 both in terms of severity of illness and mortality. Atypical presentations in older adults may result from pathophysiologic changes during aging and immune dysregulation because of the cumulative impact of chronic comorbidities. Herein we review the different clinical presentations of illness for older adults, the unique challenges faced by this population, and strategies for treatment.
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Cites
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
(2023) · doi:10.1126/science · Cited by 6,063 · see citing works
Docherty, A. B., Harrison, E. M., Green, C. A., Hardwick, H. E., Pius, R., Norman, L., Holden, K. A., Read, J. M., Dondelinger, F., Carson, G., et al. (2020) · BMJ · doi:10.1136/bmj.m1985 · Cited by 3,481 · see citing works
A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye, S. K., Bogardus, S. T., Charpentier, P. A., Leo-Summers, L. S., Acampora, D., Holford, T. R., & Cooney, L. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903043400901 · Cited by 2,904 · see citing works
Neurologic features in severe SARS-CoV-2 infection
Helms, J., Kremer, S., Merdji, H., Clere-Jehl, R., Schenck, M., Kummerlen, C., Collange, O., Boulay, C., Fafi-Kremer, S., Ohana, M., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2008597 · Cited by 2,674 · see citing works
A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans
Morley, J. E., Malmstrom, T. K., & Miller, D. K. (2012) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0084-2 · Cited by 2,032 · see citing works
Gavazzi, G., & Krause, K.-H. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00437-1 · Cited by 990 · see citing works
Wang, H., Li, T., Barbarino, P., Gauthier, S., Brodaty, H., Molinuevo, J. L., Xie, H., Sun, Y., Yu, E., Tang, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30755-8 · Cited by 562 · see citing works
Norman, D. C. (2000) · Clinical Infectious Diseases · doi:10.1086/313896 · Cited by 338 · see citing works
COVID-19 Outbreak — New York City, February 29–June 1, 2020
Thompson, C. N., Baumgartner, J., Pichardo, C., Toro, B., Li, L., Arciuolo, R. J., Chan, P. Y., Chen, J., Culp, G. M., Davidson, A., et al. (2020) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6946a2 · Cited by 323 · see citing works
Delirium in Older Patients With COVID-19 Presenting to the Emergency Department
Kennedy, M., Helfand, B., Gou, R. Y., Gartaganis, S. L., Webb, M. A., Moccia, J. M., Bruursema, S., Dokic, B., McCulloch, B., Ring, H., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.29540 · Cited by 290 · see citing works
Antipsychotics for Treating Delirium in Hospitalized Adults: A Systematic Review
Nikooie, R., Neufeld, K. J., Oh, E. S., Wilson, L. M., Zhang, A., Robinson, K. A., & Needham, D. M. (2019) · Annals of Internal Medicine · doi:10.7326/m19-1860 · Cited by 246 · see citing works
Aging immunity may exacerbate COVID-19
Akbar, A. N., & Gilroy, D. W. (2020) · Science · doi:10.1126/science.abb0762 · Cited by 209 · see citing works
Association between vision impairment and mortality: a systematic review and meta-analysis
Ehrlich, J. R., Ramke, J., Macleod, D., Burn, H., Lee, C. N., Zhang, J. H., Waldock, W. J., Swenor, B. K., Gordon, I., Congdon, N. G., et al. (2021) · The Lancet Global Health · doi:10.1016/s2214-109x(20)30549-0 · Cited by 186 · see citing works
Functional and cognitive outcomes after COVID-19 delirium
Mcloughlin, B. C., Miles, A., Webb, T. E., Knopp, P., Eyres, C., Fabbri, A., Humphries, F., & Davis, D. H. J. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00353-8 · Cited by 178 · see citing works
Delirium: a missing piece in the COVID-19 pandemic puzzle
O’Hanlon, S., & Inouye, S. K. (2020) · Age and Ageing · doi:10.1093/ageing/afaa094 · Cited by 146 · see citing works
Influence of Aging and Environment on Presentation of Infection in Older Adults
Chakhtoura, N. G. E., Bonomo, R. A., & Jump, R. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.07.017 · Cited by 126 · see citing works
From causes of aging to death from COVID-19
Blagosklonny, M. V. (2020) · Aging · doi:10.18632/aging.103493 · Cited by 123 · see citing works
Ma, Y., Hou, L., Yang, X., Huang, Z., Yang, X., Zhao, N., He, M., Shi, Y., Kang, Y. M., Yue, J., et al. (2020) · BMC Medicine · doi:10.1186/s12916-020-01761-0 · Cited by 117 · see citing works
COVID ‐19 in Older Adults: A Series of 76 Patients Aged 85 Years and Older with COVID ‐19
Vrillon, A., Hourrègue, C., Azuar, J., Grosset, L., Boutelier, A., Tan, S., Roger, M., Mourman, V., Mouly, S. J., Sène, D., et al. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16894 · Cited by 59 · see citing works
Typically Atypical: COVID ‐19 Presenting as a Fall in an Older Adult
Norman, R., Stall, N. M., & Sinha, S. K. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16526 · Cited by 48 · see citing works
Falls as One of the Atypical Presentations of COVID-19 in Older Population
Gawrońska, K., & Lorkowski, J. (2021) · Geriatric Orthopaedic Surgery & Rehabilitation · doi:10.1177/2151459321996619 · Cited by 38 · see citing works
Joining Forces against Delirium — From Organ-System Care to Whole-Human Care
Inouye, S. K. (2020) · New England Journal of Medicine · doi:10.1056/nejmp1910499 · Cited by 22 · see citing works
Cerami, C., Canevelli, M., Santi, G. C., Galandra, C., Dodich, A., Cappa, S. F., Vecchi, T., & Crespi, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.626682 · Cited by 19 · see citing works
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1 of the 25 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Life Care Center of Kirkland. Press briefing: Update from Life Care Center of Kirkland -March 13, 2020. https://lcca.com/downloads/ kirkland/Kirkland-Update-03132020.pdf Accessed September 1, 2021.
Cited by
Sorted by citations
The Lancet Commission on lessons for the future from the COVID-19 pandemic
Sachs, J. D., Karim, S. S. A., Aknin, L., Allen, J., Brosbøl, K., Colombo, F., Barron, G. C., Espinosa, M. F., Gaspar, V., Gaviria, A., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01585-9 · Cited by 842 · see citing works
Saxena, S. A., Meldon, S. W., Hashmi, A. Z., Muir, M. R., & Ruwe, J. (2023) · JAMIA Open · doi:10.1093/jamiaopen/ooad021 · Cited by 20 · see citing works
Self-citationZhu, Z., Cai, J., Tang, Q., Mo, Y., Deng, T., Zhang, X., Xu, K., Wu, B., Tang, H., & Zhang, Z. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02473-w · Cited by 8 · see citing works
The effectiveness of COVID deaths to COVID policies: A robust conditional approach
Gearhart, R. S., Michieka, N. M., & Anders, A. I. M. A. (2023) · Economic Analysis and Policy · doi:10.1016/j.eap.2023.06.026 · Cited by 5 · see citing works
Goodwin, J., Harizaj, A., Armstrong, J. N., Maloney, M., Ehrlich, H. Y., Leung, V., & Parikh, S. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.07.009 · Cited by 2 · see citing works
Saxena, S. A., Weaver, E. H., Brady, E. C., Bruckman, D., Muir, M. R., & Meldon, S. W. (2026) · Journal of the American College of Emergency Physicians Open · doi:10.1016/j.acepjo.2026.100439 · Cited by 1 · see citing works
Self-citationKarakteristik Demografi dan Klinis Berdasarkan Status Gizi Pasien Covid-19 Wisma Atlet
Yasin, Y. K., Siddiq, M. N. A. A., & Permatasari, C. A. (2025) · Al GIZZAI PUBLIC HEALTH NUTRITION JOURNAL · doi:10.24252/algizzai.v5i2.58613
- Authors
- Saxena, S., & Hashmi, A. Z.
- Affiliations
- Cleveland Clinic (US)
- Venue
- Cleveland Clinic Journal of Medicine
- Publisher
- Cleveland Clinic Journal of Medicine
- Published
- 2021-09-16
- ISSN
- 0891-1150 (ISSN-L)
- 1939-2869
- OpenAlex
- W3200499211
- Cited by
- 6
- References
- 25
- Citations by year
- 2026: 1 · 2023: 4 · 2022: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Cleveland Clinic Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pandemic, older adults, atypical presentation, immune dysregulation, chronic comorbidities, disease severity, mortality, treatment options
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