Neurological complications during treatment of middle east respiratory syndrome
Open accessAbstract
BACKGROUND AND PURPOSE: Middle East respiratory syndrome (MERS) has a high mortality rate and pandemic potential. However, the neurological manifestations of MERS have rarely been reported since it first emerged in 2012. METHODS: We evaluated four patients with laboratory-confirmed MERS coronavirus (CoV) infections who showed neurological complications during MERS treatment. These 4 patients were from a cohort of 23 patients who were treated at a single designated hospital during the 2015 outbreak in the Republic of Korea. The clinical presentations, laboratory findings, and prognoses are described. RESULTS: Four of the 23 admitted MERS patients reported neurological symptoms during or after MERS-CoV treatment. The potential diagnoses in these four cases included Bickerstaff's encephalitis overlapping with Guillain-Barré syndrome, intensive-care-unit-acquired weakness, or other toxic or infectious neuropathies. Neurological complications did not appear concomitantly with respiratory symptoms, instead being delayed by 2-3 weeks. CONCLUSIONS: Neuromuscular complications are not rare during MERS treatment, and they may have previously been underdiagnosed. Understanding the neurological manifestations is important in an infectious disease such as MERS, because these symptoms are rarely evaluated thoroughly during treatment, and they may interfere with the prognosis or require treatment modification.
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Almost 1/5 of patients with MERS-CoV infection show neurological symptoms during the infection process.
“Kim et al. also reported that almost 1/5 of patients with MERS-CoV infection show neurological symptoms during the infection process, including but not limited to disturbance of consciousness, paralysis, ischemic stroke, Guillain-Barre syndrome and other poisoning or infectious neuropathy.”
From Nervous system involvement after infection with COVID-19 and other coronaviruses (2020) · cites this paper as Kim et al., 2017
Neurological complications in MERS-CoV patients are not accompanied by respiratory symptoms but delayed by 2-3 weeks.
“Interestingly, their neurological complications are not accompanied by respiratory symptoms, but delayed by 2–3 weeks (Kim et al., 2017).”
From Nervous system involvement after infection with COVID-19 and other coronaviruses (2020) · cites this paper as Kim et al., 2017
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- Authors
- Kim, J.-E., Heo, J.-H., Kim, H.-O., Song, S.-H., Park, S.-S., Park, T.-H., Ahn, J.-Y., Kim, M.-K., & Choi, J.-P.
- Affiliations
- Seoul Medical Center (KR)
- Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
- Corresponding author
- Kim, Jee-Eun
- Choi, Jae-Phil
- Venue
- Journal of Clinical Neurology
- Publisher
- Korean Neurological Association
- Published
- 2017
- Volume
- 13
- Issue
- 3
- Pages
- 227
- ISSN
- 1738-6586 (ISSN-L)
- 2005-5013
- PMC
- PMC5532318
- OpenAlex
- W2738307679
- Cited by
- 497
- References
- 27
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 30 · 2022: 52 · 2021: 150 · 2020: 230 · 2019: 4 · 2018: 2 · 2017: 2
- FWCI
- 45.31
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Clinical Neurology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- MERS, MERS-CoV, neurological complications, Guillain-Barré syndrome, ICU-acquired weakness, toxic neuropathy, infectious neuropathy, neuromuscular complications
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