Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia
Open accessAbstract
OBJECTIVES: To report the experience with Middle East respiratory syndrome coronavirus (MERS-CoV) infection at a single center in Saudi Arabia. METHODS: Cases of laboratory-confirmed MERS-CoV occurring from October 1, 2012 to May 31, 2014 were reviewed retrospectively. Information sources included medical files, infection control outbreak investigations, and the preventive medicine database of MERS-CoV-infected patients. Data were collected on clinical and epidemiological aspects and outcomes. RESULTS: Seventy consecutive patients were included. Patients were mostly of older age (median 62 years), male (46, 65.7%), and had healthcare acquisition of infection (39, 55.7%). Fever (43, 61.4%), dyspnea (42, 60%), and cough (38, 54.3%) were the most common symptoms. The majority developed pneumonia (63, 90%) and required intensive care (49, 70%). Infection commonly occurred in clusters. Independent risk factors for severe infection requiring intensive care included concomitant infections (odds ratio (OR) 14.13, 95% confidence interval (CI) 1.58-126.09; p=0.018) and low albumin (OR 6.31, 95% CI 1.24-31.90; p=0.026). Mortality was high (42, 60%), and age ≥65 years was associated with increased mortality (OR 4.39, 95% CI 2.13-9.05; p<0.001). CONCLUSIONS: MERS-CoV can cause severe infection requiring intensive care and has a high mortality. Concomitant infections and low albumin were found to be predictors of severe infection, while age ≥65 years was the only predictor of increased mortality.
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MERS-CoV is potentially neuroinvasive.
“MERS-CoV is known to be potentially neuroinvasive”
From Nervous system involvement after infection with COVID-19 and other coronaviruses (2020) · cites this paper as Saad et al., 2014
25.7% of patients with MERS develop insanity and 8.6% have seizures.
“a retrospective study found that 25.7% of patients with MERS can develop insanity and 8.6% of patients have seizures (Saad et al., 2014).”
From Nervous system involvement after infection with COVID-19 and other coronaviruses (2020) · cites this paper as Saad et al., 2014
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- Authors
- Saad, M., Omrani, A. S., Baig, K., Bahloul, A., Elzein, F., Matin, M. A., Selim, M. A. A., Mutairi, M. A., Nakhli, D. A., Aidaroos, A. Y. A., Sherbeeni, N. A., Al-Khashan, H. I., Memish, Z. A., & Albarrak, A. M.
- Affiliations
- Riyadh Armed Forces Hospital (SA)
- Alfaisal University (SA)
- Corresponding author
- Memish, Ziad A.
- Venue
- International Journal of Infectious Diseases
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 29
- Pages
- 301-306
- ISSN
- 1201-9712 (ISSN-L)
- PMC
- PMC7110769
- OpenAlex
- W1984328389
- Cited by
- 486
- References
- 21
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 18 · 2022: 36 · 2021: 107 · 2020: 173 · 2019: 18 · 2018: 11 · 2017: 21 · 2016: 40 · 2015: 35
- FWCI
- 22.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Infectious Diseases (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- MERS-CoV, clinical outcomes, mortality, intensive care, pneumonia, nosocomial infections, concomitant infection, low albumin, risk factors, old age, Saudi Arabia
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Saudi Arabia, Coronavirus Infections, Middle East Respiratory Syndrome Coronavirus
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