Cited by 14Advanced Chemical Sensor TechnologiesSpectroscopy and Laser ApplicationsOdor and Emission Control Technologies

Exhaled Breath Volatile Organic Compound Analysis for the Detection of Lung Cancer- A Systematic Review

Binson, V.A., Subramoniam, M.·2022·Journal of Biomimetics, Biomaterials and Biomedical Engineering

Abstract

A rapid and effective diagnostic method is essential for lung cancer since it shows symptoms only at its advanced stage. Research is being carried out in the area of exhaled breath analysis for the diagnosis of various pulmonary diseases including lung cancer. In this method exhaled breath volatile organic compounds (VOC) are analyzed with various techniques such as gas chromatography-mass spectrometry, ion mobility spectrometry, and electronic noses. The VOC analysis is suitable for lung cancer detection since it is non-invasive, fast, and also a low-cost method. In addition, this technique can detect primary stage nodules. This paper presents a systematic review of the various method employed by researchers in the breath analysis field. The articles were selected through various search engines like EMBASE, Google Scholar, Pubmed, and Google. In the initial screening process, 214 research papers were selected using various inclusion and exclusion criteria and finally, 55 articles were selected for the review. The results of the reviewed studies show that detection of lung cancer can be effectively done using the VOC analysis of exhaled breath. The results also show that this method can be used for detecting the different stages and histology of lung cancer. The exhaled breath VOC analysis technique will be popular in the future, bypassing the existing imaging techniques. This systematic review conveys the recent research opportunities, obstacles, difficulties, motivations, and suggestions associated with the breath analysis method for lung cancer detection.

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Crossref · 10.4028/p-dab04j

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Authors
Binson, V. A., & Subramoniam, M.
Affiliations
Sathyabama Institute of Science and Technology (IN)
Corresponding author
Binson, V.A.
Venue
Journal of Biomimetics, Biomaterials and Biomedical Engineering
Published
2022-05-20
Volume
56
Pages
17-35
ISSN
  • 2296-9837 (ISSN-L)
  • 2296-9845
OpenAlex
W4280579615
Cited by
14
References
76
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2021: 2
FWCI
0.24
Type
journal article
Language
en
Open access
closed
Locations
Journal of biomimetics, biomaterials and biomedical engineering (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Advanced Chemical Sensor Technologies
  • Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
  • Physical Sciences › Chemical Engineering › Process Chemistry and Technology › Odor and Emission Control Technologies
Keywords
lung cancer detection, breath analysis, volatile organic compounds, non-invasive diagnosis, gas chromatography-mass spectrometry, ion mobility spectrometry, electronic nose, lung cancer histology, lung cancer staging

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