Characterization of a CD44/CD122int Memory CD8 T Cell Subset Generated under Sterile Inflammatory Conditions
Abstract
Most memory CD8 T cell subsets that have been hitherto defined are generated in response to infectious pathogens. In this study, we have characterized the CD8 T cells that survive priming conditions, devoid of pathogen-derived danger signals. In both a TCR-transgenic model and a model of contact hypersensitivity, we show that the priming of naive CD8 T cells under sterile inflammatory conditions generates memory. The corresponding memory CD8 T cells can be identified by their intermediate expression levels of CD44 and CD122. We also show that CD44/122int memory CD8 T cells spontaneously develop in wild type mice and that they display intermediate levels of several other memory traits including functional (IFN-γ secretion capacity, CCL5 messenger stores), phenotypic, and molecular (T-bet and eomesodermin expression levels) features. We finally show that they correspond to an early differentiation stage and can further differentiate in CD44/122high memory T cells. Altogether, our results identify a new memory CD8 T cell subset that is generated under sterile inflammatory conditions and involved in the recall contact hypersensitivity reactions that are responsible for allergic contact dermatitis.
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Inflammatory responses during infection are very similar to responses induced by sterile stimuli, including recruitment of neutrophils and macrophages, production of inflammatory cytokines and chemokines, and induction of T cell-mediated adaptive immune responses.
“Moreover, inflammatory responses during infection are very similar to responses induced by sterile stimuli, including the recruitment of neutrophils and macrophages, the production of inflammatory cytokines and chemokines, and the induction of T cell-mediated adaptive immune responses23.”
From Sterile inflammation: sensing and reacting to damage (2010) · cites this paper as [23]
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- Authors
- Mbitikon-Kobo, F.-M., Vocanson, M., Michallet, M.-C., Tomkowiak, M., Cottalorda, A., Angelov, G. S., Coupet, C.-A., Djebali, S., Marçais, A., Dubois, B., Bonnefoy-Bérard, N., Nicolas, J.-F., Arpin, C., & Marvel, J.
- Affiliations
- Lyon 1 Université (FR)
- Université de Lyon ,
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 182
- Issue
- 6
- Pages
- 3846-3854
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1606948051
- Cited by
- 34
- References
- 46
- Citations by year
- 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- memory CD8+ T cells, CD44, CD122, sterile inflammation, T cell priming, contact hypersensitivity, allergic contact dermatitis, TCR transgenic mice, T cell differentiation, interferon-gamma, RANTES, T-bet, Eomesodermin
- MeSH terms
- Animals, Cell Differentiation, Dermatitis, Contact, Immunologic Memory, Lymphocyte Activation, Mice, Inbred C57BL, Mice, Transgenic, Biomarkers, T-Lymphocyte Subsets, Mice, Knockout, CD8-Positive T-Lymphocytes, Inflammation Mediators, Hyaluronan Receptors, Mice, Interleukin-2 Receptor beta Subunit
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