The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Autophagy and Its Role in MHC-Mediated Antigen Presentation
Open accessAbstract
Intracellular degradation by autophagy plays a role in the maintenance of cellular homeostasis under normal conditions and during periods of cellular stress. Autophagy has also been implicated in several other cellular processes including immune recognition and responsiveness. More specifically, autophagy has been identified as a route by which cytoplasmic and nuclear Ag are delivered to MHC class II molecules for presentation to CD4+ T cells. Autophagy has also recently been implicated in MHC class I cross-presentation of tumor Ag and the activation of CD8+ T cells. This review discusses the role of autophagy in modulating MHC class I and class II Ag presentation as well as its implication in regulating autoimmunity and tolerance, tumor immunity, and host defense against intracellular pathogens.
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Cites
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Autophagy as a Regulated Pathway of Cellular Degradation
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IRF-7 is the master regulator of type-I interferon-dependent immune responses
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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
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Cited by
Martinez, J., Almendinger, J., Oberst, A., Ness, R., Dillon, C. P., Fitzgerald, P., Hengartner, M. O., & Green, D. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113421108 · Cited by 655
RetractedImmunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis
Hmama, Z., Peña‐Díaz, S., Joseph, S., & Av‐Gay, Y. (2015) · Immunological Reviews · doi:10.1111/imr.12268 · Cited by 290
Impact of aging on dendritic cell functions in humans
Agrawal, A., & Gupta, S. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.06.004 · Cited by 246
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Junker, F., Gordon, J., & Qureshi, O. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01393 · Cited by 219
Antigen processing and presentation
(2019) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.07.005 · Cited by 194
Metadata
- Authors
- Crotzer, V. L., & Blum, J. S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-03
- Volume
- 182
- Issue
- 6
- Pages
- 3335-3341
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1624269400
- Cited by
- 281
- References
- 74
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
