The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4
Open accessAbstract
Peroxiredoxin 1 (Prx1) is an antioxidant and molecular chaperone that can be secreted from tumor cells. Prx1 is overexpressed in many cancers, and elevation of Prx1 is associated with poor clinical outcome. In the current study, we demonstrate that incubation of Prx1 with thioglycollate-elicited murine macrophages or immature bone marrow-derived dendritic cells resulted in TLR4-dependent secretion of TNF-α and IL-6 and dendritic cell maturation. Optimal secretion of cytokines in response to Prx1 was dependent upon serum and required CD14 and MD2. Binding of Prx1 to thioglycollate macrophages occurred within minutes and resulted in TLR4 endocytosis. Prx1 interaction with TLR4 was independent of its peroxidase activity and appeared to be dependent on its chaperone activity and ability to form decamers. Cytokine expression occurred via the TLR-MyD88 signaling pathway, which resulted in nuclear translocation and activation of NF-κB. These findings suggest that Prx1 may act as danger signal similar to other TLR4-binding chaperone molecules such as HSP72.
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Citations
Cites
A cytokine-mediated link between innate immunity, inflammation, and cancer
Lin, W.-W., & Karin, M. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31537 · Cited by 1,940 · cited 1×
“TLR4-induced gene activation is mediated through bothMyD88dependent and -independent pathways (21).”
BackgroundTian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372
High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
Bianchi, M. E., & Manfredi, A. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00574.x · Cited by 600
Cited by
Rhee, S. G., & Woo, H. A. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3393 · Cited by 463
Factors Affecting Protein Thiol Reactivity and Specificity in Peroxide Reduction
Ferrer-Sueta, G., Manta, B., Botti, H., Radi, R., Trujillo, M., & Denicola, A. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100413v · Cited by 289
Metadata
- Authors
- Riddell, J. R., Wang, X.-Y., Minderman, H., & Gollnick, S. O.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-27
- Volume
- 184
- Issue
- 2
- Pages
- 1022-1030
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1943329167
- Cited by
- 208
- References
- 3
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Riddell, J. R., Wang, X.-Y., Minderman, H., & Gollnick, S. O. (2010). Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0901945
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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