High‐mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
Abstract
Summary: Tissue damage occurs often in the life of mammals and is usually repaired. Dying cells are swiftly phagocytosed, but before disappearing, they alert surrounding cells to activate homeostatic programs. They release signals that recruit inflammatory cells to the site of injury, promote cell migration and cell division to replace dead cells, and activate the immune system in anticipation of microbial invasion. Many of these events involve high‐mobility group box 1 protein (HMGB1), a nuclear protein that is released passively when necrotic cells lose the integrity of their membranes. HMGB1 behaves as a trigger of inflammation, attracting inflammatory cells, and of tissue repair, recruiting stem cells and promoting their proliferation. Moreover, HMGB1 activates dendritic cells (DCs) and promotes their functional maturation and their response to lymph node chemokines. Activated leukocytes actively secrete HMGB1 in the microenvironment. Thus, HMGB1 acts in an autocrine/paracrine fashion and sustains long‐term repair and defense programs. DCs secrete HMGB1 several hours after contact with the first maturation stimulus; HMGB1 secretion is critical for their ability to reach the lymph nodes, to sustain the proliferation of antigen‐specific T cells, to prevent their activation‐dependent apoptosis, and to promote their polarization towards a T‐helper 1 phenotype. These immune responses will also be directed against self‐antigens that DCs process at the time of injury and can lead to autoimmunity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pattern recognition receptors on or within dendritic cells include signaling receptors that stimulate post-uptake reactions, such as toll-like receptors, NOD-like receptors, and RIG1-like helicases.
“Moreover, PRR present on or within DC include a group of signaling receptors that stimulate the post uptake reactions (including toll-like receptors, NOD-like receptors, and RIG1-like helicases)52,107.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [52]
Heat shock proteins exposed on or released by tumor cells may act on multiple receptors including CD91, scavenger receptors, TLR2 and TLR4.
“Similarly, HSPs exposed on or released by tumor cells may act on multiple receptors including CD91, scavenger receptors, TLR2 and TLR4 52.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [52]
HMGB1 may act on RAGE and possibly on TLR2 and TLR4, although the TLR action is controversial.
“Thus, HMGB1 may act on the receptor for advanced glycated endproducts (RAGEs) and possibly the toll-like receptors (TLRs) including TLR2 and TLR4 51,52, although the latter are controversial 53.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [52]
Cites
Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221 · see citing works
Self-citationHMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386 · see citing works
Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056 · see citing works
DAMPs, PAMPs and alarmins: all we need to know about danger
Bianchi, M. E. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306164 · Cited by 2,794 · see citing works
Self-citationChromatin–IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Leadbetter, E. A., Rifkin, I. R., Hohlbaum, A. M., Beaudette-Zlatanova, B. C., Shlomchik, M. J., & Marshak‐Rothstein, A. (2002) · Nature · doi:10.1038/416603a · Cited by 1,899 · see citing works
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,560 · see citing works
Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401 · see citing works
Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372 · see citing works
Understanding RAGE, the receptor for advanced glycation end products
Bierhaus, A., Humpert, P. M., Morcos, M., Wendt, T., Chavakis, T., Arnold, B., Stern, D. M., & Nawroth, P. P. (2005) · Journal of Molecular Medicine · doi:10.1007/s00109-005-0688-7 · Cited by 1,297 · see citing works
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
Bonaldi, T., Talamo, F., Scaffidi, P., Ferrera, D., Porto, A., Bachi, A., Rubartelli, A., Agresti, A., & Bianchi, M. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg516 · Cited by 1,252 · see citing works
Self-citationThe Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin
Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151 · see citing works
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
Yang, H., Ochani, M., Li, J., Qiang, X., Tanovic, M., Harris, H. E., Susarla, S. M., Ulloa, L., Wang, H., DiRaimo, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2434651100 · Cited by 1,126 · see citing works
The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
Tsung, A., Sahai, R., Tanaka, H., Nakao, A., Fink, M. P., Lotze, M. T., Yang, H., Li, J., Tracey, K. J., Geller, D. A., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042614 · Cited by 1,113 · see citing works
Dendritic-cell trafficking to lymph nodes through lymphatic vessels
Randolph, G. J., Angeli, V., & Swartz, M. A. (2005) · Nature Reviews Immunology · doi:10.1038/nri1670 · Cited by 1,111 · see citing works
Gardella, S., Andrei, C., Ferrera, D., Lotti, L. V., Torrisi, M. R., Bianchi, M. E., & Rubartelli, A. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf198 · Cited by 926 · see citing works
Self-citationβ-Cell death during progression to diabetes
Mathis, D. J., Vence, L., & Benoist, C. O. (2001) · Nature · doi:10.1038/414792a · Cited by 884 · see citing works
A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids
Goodwin, G. H., Sanders, C., & Johns, E. W. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb03026.x · Cited by 783 · see citing works
Protection from septic shock by neutralization of macrophage migration inhibitory factor
Calandra, T., Echtenacher, B., Roy, D. L., Pugin, J., Metz, C. N., Hültner, L., Heumann, D., Männel, D. N., Bucala, R., & Glauser, M. P. (2000) · Nature Medicine · doi:10.1038/72262 · Cited by 724 · see citing works
Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation
Abraham, E. H., Arcaroli, J. J., Carmody, A., Wang, H., & Tracey, K. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.2950 · Cited by 692 · see citing works
HMG1 and 2, and related ‘architectural’ DNA-binding proteins
Thomas, J. O., & TRAVERS, A. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01801-1 · Cited by 619 · see citing works
HMGB1 is an endogenous immune adjuvant released by necrotic cells
Rovere, P. Q., Capobianco, A., Scaffidi, P., Valentinis, B., Catalanotti, F., Giazzon, M., Dumitriu, I. E., Müller, S., Iannacone, M., Traversari, C., et al. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400205 · Cited by 591 · see citing works
Self-citationThe extracellular release of HMGB1 during apoptotic cell death
Bell, C. W., Jiang, W., Reich, C. F., & Pisetsky, D. S. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00616.2005 · Cited by 538 · see citing works
Calogero, S., Grassi, F., Aguzzi, A., Voigtländer, T., Ferrier, P., Ferrari, S., & Bianchi, M. E. (1999) · Nature Genetics · doi:10.1038/10338 · Cited by 528 · see citing works
Self-citationLiliensiek, B., Weigand, M. A., Bierhaus, A., Nicklas, W., Kasper, M. E., Hofer, S., Plachky, J., Gröne, H.-J., Kurschus, F. C., Schmidt, A. M., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18704 · Cited by 525 · see citing works
HMG proteins: dynamic players in gene regulation and differentiation
Bianchi, M. E., & Agresti, A. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.08.007 · Cited by 521 · see citing works
Self-citationDumitriu, I. E., Baruah, P., Valentinis, B., Voll, R. E., Herrmann, M., Nawroth, P. P., Arnold, B., Bianchi, M. E., Manfredi, A. A., & Rovere-Querini, P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7506 · Cited by 503 · see citing works
Self-citationRAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages
Kokkola, R., Andersson, Å., Mullins, G. E., Östberg, T., Treutiger, C.-J., Arnold, B., Nawroth, P. P., Andersson, J., Harris, R. A., & Harris, H. E. (2005) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2005.01534.x · Cited by 496 · see citing works
Hristov, M., Erl, W., Linder, S., & Weber, P. C. (2004) · Blood · doi:10.1182/blood-2003-10-3614 · Cited by 485 · see citing works
A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA
Ivanov, S. S., Dragoi, A., Wang, X., Dallacosta, C., Louten, J., Musco, G., Sitia, G., Yap, G. S., Wan, Y., Biron, C. A., et al. (2007) · Blood · doi:10.1182/blood-2006-09-044776 · Cited by 472 · see citing works
Self-citationExtracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation
Palumbo, R., Sampaolesi, M., Marchis, F. D., Tonlorenzi, R., Colombetti, S., Mondino, A., Cossu, G., & Bianchi, M. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200304135 · Cited by 469 · see citing works
Self-citationLiliensiek, B., Weigand, M. A., Bierhaus, A., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200418704 · Cited by 468 · see citing works
Degryse, B., Bonaldi, T., Scaffidi, P., Müller, S., Resnati, M., Sanvito, F., Arrigoni, G., & Bianchi, M. E. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.6.1197 · Cited by 451 · see citing works
Self-citationMessmer, D., Yang, H., Telusma, G., Knoll, F., Li, J., Messmer, B., Tracey, K. J., & Chiorazzi, N. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.1.307 · Cited by 447 · see citing works
The double life of HMGB1 chromatin protein: architectural factor and extracellular signal
Müller, S., Scaffidi, P., Degryse, B., Bonaldi, T., Ronfani, L., Agresti, A., Beltrame, M., & Bianchi, M. E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.16.4337 · Cited by 427 · see citing works
Self-citationRole of HMGB1 in apoptosis-mediated sepsis lethality
Qin, S., Wang, H., Yuan, R., Li, H., Ochani, M., Ochani, K., Rosas‐Ballina, M., Czura, C. J., Huston, J. M., Miller, E., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052203 · Cited by 401 · see citing works
HMGB proteins and gene expression
Agresti, A., & Bianchi, M. E. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00023-6 · Cited by 394 · see citing works
Self-citationA novel pathway of HMGB1‐mediated inflammatory cell recruitment that requires Mac‐1‐integrin
Orlova, V. V., Choi, E. Y., Xie, C., Chavakis, E., Bierhaus, A., Ihanus, E., Ballantyne, C. M., Gahmberg, C. G., Bianchi, M. E., Nawroth, P. P., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601552 · Cited by 381 · see citing works
Self-citationYang, D., Chen, Q., Yang, H., Tracey, K. J., Bustin, M., & Oppenheim, J. J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306180 · Cited by 379 · see citing works
Botezatu, I. V., Serdyuk, O. I., Потапова, Г. И., Shelepov, V. P., Alechina, R. P., Molyaka, Y., Vs, A., Bazin, I. S., Garin, A. M., Narimanov, M., et al. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.8.1078 · Cited by 379 · see citing works
Müller, S., Ronfani, L., & Bianchi, M. E. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01296.x · Cited by 368 · see citing works
Self-citationYoun, J. H., & Shin, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7889 · Cited by 367 · see citing works
Rumore, P. M., & Steinman, C. R. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114716 · Cited by 366 · see citing works
Hepatic Ischemia/Reperfusion Injury Involves Functional TLR4 Signaling in Nonparenchymal Cells
Tsung, A., Hoffman, R. A., Izuishi, K., Critchlow, N. D., Nakao, A., Chan, M., Lotze, M. T., Geller, D. A., & Billiar, T. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7661 · Cited by 362 · see citing works
Mechanisms of Disease: a 'DAMP' view of inflammatory arthritis
Foell, D., Wittkowski, H., & Roth, J. (2007) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0531 · Cited by 350 · see citing works
High-Mobility Group Box 1 Activates Integrin-Dependent Homing of Endothelial Progenitor Cells
Chavakis, E., Hain, A., Vinci, M., Carmona, G., Bianchi, M. E., Vajkoczy, P., Zeiher, A. M., Chavakis, T., & Dimmeler, S. (2007) · Circulation Research · doi:10.1161/01.res.0000257774.55970.f4 · Cited by 298 · see citing works
Self-citationRonchetti, A. B., Rovere, P. Q., Iezzi, G., Galati, G., Heltai, S., Protti, M. P., Garancini, M. P., Manfredi, A. A., Rugarli, C., & Bellone, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.130 · Cited by 293 · see citing works
Self-citationLimana, F., Germani, A., Zacheo, A., Kajstura, J., Carlo, A. D., Borsellino, G., Leoni, O., Palumbo, R., Battistini, L., Rastaldo, R., et al. (2005) · Circulation Research · doi:10.1161/01.res.0000186276.06104.04 · Cited by 289 · see citing works
Self-citationSystemic lupus erythematosus: all roads lead to type I interferons
Pascual, V., Farkas, L., & Banchereau, J. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.09.014 · Cited by 285 · see citing works
Clearance deficiency and systemic lupus erythematosus (SLE)
Gaipl, U. S., Munoz, L. E., Grossmayer, G., Lauber, K., Franz, S., Sarter, K., Voll, R. E., Winkler, T., Kuhn, A., Kalden, J., et al. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.02.005 · Cited by 277 · see citing works
Increased Expression of the DNA-Binding Cytokine HMGB1 in Human Atherosclerotic Lesions
Kalinina, N., Agrotis, A., Antropova, Y., Vitto, G. D., Kanellakis, P., Kostolias, G., Ilyinskaya, O. P., Tararak, E. M., & Bobik, A. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000145573.36113.8a · Cited by 275 · see citing works
The secretion of HMGB1 is required for the migration of maturing dendritic cells
Dumitriu, I. E., Bianchi, M. E., Bacci, M., Manfredi, A. A., & Rovere, P. Q. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306171 · Cited by 247 · see citing works
Self-citationIto, I., Fukazawa, J., & Yoshida, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608467200 · Cited by 243 · see citing works
Su, Y., Wang, M., Brenner, D. E., Ng, A. K. L., Melkonyan, H. S., Umansky, S. R., Syngal, S., & Block, T. M. (2004) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60497-7 · Cited by 240 · see citing works
Cutting Edge: Extracellular High Mobility Group Box-1 Protein Is a Proangiogenic Cytokine
Mitola, S. M. F., Belleri, M., Urbinati, C., Coltrini, D., Sparatore, B., Pedrazzi, M., Melloni, E., & Presta, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.12 · Cited by 229 · see citing works
Angiogenetic Signaling through Hypoxia
Schlueter, C., Weber, H., Meyer, B., Rogalla, P., Röser, K., Hauke, S., & Bullerdiek, J. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62344-9 · Cited by 229 · see citing works
Yang, R., Harada, T., Mollen, K. P., Prince, J. M., Levy, R. M., Englert, J. A., Gallowitsch‐Puerta, M., Yang, L., Yang, H., Tracey, K. J., et al. (2006) · Molecular Medicine · doi:10.2119/2006-00010.yang · Cited by 221 · see citing works
Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
Rouhiainen, A., Tumova, S., Valmu, L., Kalkkinen, N., & Rauvala, H. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306200 · Cited by 214 · see citing works
Golpon, H. A., Fadok, V. A., Tarasevičienė-Stewart, L., Scerbavicius, R., Sauer, C., Welte, T., Henson, P. M., & Voelkel, N. F. (2004) · The FASEB Journal · doi:10.1096/fj.04-1853fje · Cited by 212 · see citing works
Receptor for advanced glycation end‐products is a marker of type I lung alveolar cells
Shirasawa, M., Fujiwara, N., Hirabayashi, S., Ohno, H., Iida, J., Makita, K., & Hata, Y. (2004) · Genes to Cells · doi:10.1111/j.1356-9597.2004.00712.x · Cited by 204 · see citing works
Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2
Ronfani, L., Ferraguti, M., Croci, L., Ovitt, C. E., Schöler, H. R., Consalez, G. G., & Bianchi, M. E. (2001) · Development · doi:10.1242/dev.128.8.1265 · Cited by 198 · see citing works
Self-citationComplete repair of dystrophic skeletal muscle by mesoangioblasts with enhanced migration ability
Gálvez, B. G., Sampaolesi, M., Brunelli, S., Covarello, D., Gavina, M., Rossi, B., Constantin, G., Torrente, Y., & Cossu, G. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200512085 · Cited by 196 · see citing works
Porto, A., Palumbo, R., Pieroni, M., Aprigliano, G., Chiesa, R., Sanvito, F., Maseri, A., & Bianchi, M. E. (2006) · The FASEB Journal · doi:10.1096/fj.06-5867fje · Cited by 182 · see citing works
Self-citationHMGB1 is a potent trigger of arthritis
Andersson, J., & Erlandsson-Harris, H. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01303.x · Cited by 169 · see citing works
Desai‐Mehta, A., Mao, C., Rajagopalan, S., Robinson, T., & Datta, S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117695 · Cited by 161 · see citing works
Contribution of High-Mobility Group Box-1 to the Development of Ventilator-induced Lung Injury
Ogawa, E. N., Ishizaka, A., Tasaka, S., Koh, H., Ueno, H., Amaya, F., Ebina, M., Yamada, S., Funakoshi, Y., Soejima, J., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200605-699oc · Cited by 146 · see citing works
Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus
Cook, H. T., & Botto, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0191 · Cited by 145 · see citing works
Interleukin-1 Stimulates β-Cell Necrosis and Release of the Immunological Adjuvant HMGB1
Steer, S. A., Scarim, A. L., Chambers, K. T., & Corbett, J. A. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0030017 · Cited by 144 · see citing works
Mahoney, J. A., & Rosen, A. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.09.018 · Cited by 140 · see citing works
Popovic, K., Ek, M., Espinosa, A., Padyukov, L., Harris, H. E., Wahren‐Herlenius, M., & Nyberg, F. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21398 · Cited by 140 · see citing works
HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques
Inoue, K., Kawahara, K., Biswas, K. K., Ando, K., Mitsudo, K., Nobuyoshi, M., & Maruyama, I. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2006.11.006 · Cited by 136 · see citing works
Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
Sitia, G., Iannacone, M., Müller, S., Bianchi, M. E., & Guidotti, L. G. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306173 · Cited by 134 · see citing works
Self-citationRequirements for Apoptotic Cell Contact in Regulation of Macrophage Responses
Lucas, M., Stuart, L. M., Zhang, A., Hodivala‐Dilke, K., Febbraio, M., Silverstein, R. L., Savill, J., & Lacy‐Hulbert, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.4047 · Cited by 133 · see citing works
Bianchi, M. E., & Manfredi, A. A. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2003.10.017 · Cited by 123 · see citing works
Self-citationIncreasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
Tsung, A., Zheng, N., Jeyabalan, G., Izuishi, K., Klune, J. R., Geller, D. A., Lotze, M. T., Lü, L., & Billiar, T. R. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0706468 · Cited by 118 · see citing works
Knapp, S., Müller, S., Digilio, G., Bonaldi, T., Bianchi, M. E., & Musco, G. (2004) · Biochemistry · doi:10.1021/bi049364k · Cited by 106 · see citing works
Self-citationCytolytic cells induce HMGB1 release from melanoma cell lines
Ito, N., DeMarco, R., Mailliard, R. B., Han, J., Rabinowich, H., Kaliński, P., Stolz, D. B., Zeh, H. J., & Lotze, M. T. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306169 · Cited by 100 · see citing works
The evolution of High Mobility Group Box (HMGB) chromatin proteins in multicellular animals
Sessa, L., & Bianchi, M. E. (2006) · Gene · doi:10.1016/j.gene.2006.08.034 · Cited by 95 · see citing works
Self-citationMoser, B., Szabolcs, M., Ankersmit, H. J., Lu, Y. F., Qu, W., Weinberg, A. D., Herold, K., & Schmidt, A. (2007) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2006.01617.x · Cited by 91 · see citing works
Requirement of dying cells and environmental adjuvants for the induction of autoimmunity
Bondanza, A., Zimmermann, V. S., DellʼAntonio, G., Cin, E. D., Balestrieri, G., Tincani, A., Amoura, Z., Pietté, J. C., Sabbadini, M. G., Rovere, P. Q., et al. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20187 · Cited by 73 · see citing works
Self-citationCoupling Toll-like receptor signaling with phagocytosis: potentiation of antigen presentation
Blander, J. M. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.11.001 · Cited by 68 · see citing works
Nemeth, M. J., Cline, A. P., Anderson, S. M., Garrett-Beal, L. J., & Bodine, D. M. (2004) · Blood · doi:10.1182/blood-2004-07-2551 · Cited by 66 · see citing works
The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mechanism
Wang, Q., Zeng, M., Wang, W., & Tang, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.130 · Cited by 61 · see citing works
Sobajima, J., Ozaki, S., Uesugi, H., Osakada, F., Shirakawa, H., Yoshida, M., & Nakao, K. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00491.x · Cited by 57 · see citing works
Does physiological β cell turnover initiate autoimmune diabetes in the regional lymph nodes?
Pearl-Yafe, M., Iskovich, S., Kaminitz, A., Stein, J., Yaniv, I., & Askenasy, N. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.02.005 · Cited by 18 · see citing works
High Mobility Group Box 1 Protein
Delude, R. L. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4252-5.50162-3 · Cited by 8 · see citing works
Sawalha, A. H., Diaz, L. A., & Harley, J. B. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_99 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Immunogenic and tolerogenic cell death
Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works
Kang, R., Chen, R., Zhang, Q., Hou, W., Wu, S., Cao, L., Huang, J., Yu, Y., Fan, X.-G., Yan, Z., et al. (2014) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.05.001 · Cited by 956 · see citing works
Consensus guidelines for the detection of immunogenic cell death
Kepp, O., Senovilla, L., Vitale, I., Vacchelli, E., Adjemian, S., Agostinis, P., Apetoh, L., Aranda, F., Barnaba, V., Bloy, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.955691 · Cited by 832 · see citing works
Self-citationHMGB1: Endogenous Danger Signaling
Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works
HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
Yanai, H., Ban, T., Wang, Z., Choi, M. K., Kawamura, T., Negishi, H., Nakasato, M., Lu, Y., Hangai, S., Koshiba, R., et al. (2009) · Nature · doi:10.1038/nature08512 · Cited by 683 · see citing works
Self-citationPara-Inflammation in the Aging Retina
Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · see citing works
Sparvero, L. J., Asafu-Adjei, D. A., Kang, R., Tang, D., Amin, N., Im, J., Rutledge, R., Lin, B., Amoscato, A. A., Zeh, H. J., et al. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-17 · Cited by 625 · see citing works
HMGB proteins: Interactions with DNA and chromatin
Štros, M. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.09.008 · Cited by 605 · see citing works
Epilepsy and brain inflammation
Vezzani, A., Aronica, E., Mazarati, A., & Pittman, Q. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.033 · Cited by 508 · see citing works
Raucci, A., Cugusi, S., Antonelli, A., Barabino, S. M. L., Monti, L. D., Bierhaus, A., Reiß, K., Säftig, P., & Bianchi, M. E. (2008) · The FASEB Journal · doi:10.1096/fj.08-109033 · Cited by 560 · see citing works
Self-citationAlarmins: awaiting a clinical response
Chan, J. K.-K., Roth, J., Oppenheim, J. J., Tracey, K. J., Vogl, T., Feldmann, M., Horwood, N. J., & Nanchahal, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62423 · Cited by 507 · see citing works
The role of inflammation in epileptogenesis
Vezzani, A., Friedman, A., & Dingledine, R. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.004 · Cited by 499 · see citing works
Romero, R. J., Miranda, J., Chaiworapongsa, T., Korzeniewski, S. J., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., et al. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12296 · Cited by 488 · see citing works
Myeloid-Derived Suppressor Cells
Parker, K. H., Beury, D. W., & Ostrand‐Rosenberg, S. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.002 · Cited by 482 · see citing works
Mayer-Barber, K. D., Barber, D. L., Shenderov, K., White, S., Wilson, M. S., Cheever, A. W., Kugler, D. G., Hieny, S. E., Caspar, P., Núñez, G., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904189 · Cited by 472 · see citing works
High-Mobility Group Box 1, Oxidative Stress, and Disease
Tang, D., Kang, R., Zeh, H. J., & Lotze, M. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3356 · Cited by 465 · see citing works
The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage
Muhammad, S., Barakat, W., Stoyanov, S., Murikinati, S. R., Yang, H., Tracey, K. J., Bendszus, M., Rossetti, G., Nawroth, P. P., Bierhaus, A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2435-08.2008 · Cited by 412 · see citing works
Sangaletti, S., Tripodo, C., Chiodoni, C., Guarnotta, C., Cappetti, B., Casalini, P., Piconese, S., Parenza, M., Guiducci, C., Vitali, C., et al. (2012) · Blood · doi:10.1182/blood-2012-03-416156 · Cited by 398 · see citing works
Allavena, P., & Mantovani, A. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04515.x · Cited by 383 · see citing works
Parainflammation, Chronic Inflammation and Age-Related Macular Degeneration
Chen, M., & Xu, H. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ri0615-239r · Cited by 381 · see citing works
Hu, S., Xie, Z., Onishi, A., Yu, X., Jiang, L., Lin, J., Rho, H., Woodard, C. L., Wang, H., Jeong, J. S., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.037 · Cited by 377 · see citing works
Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?
MEYER, U., FELDON, J., & DAMMANN, O. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212c196 · Cited by 357 · see citing works
“HMGB1 is a highly conserved, ubiquitous protein that activates inflammation-associated immune responses (59).”
RAGE: a single receptor fits multiple ligands
Fritz, G. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.08.008 · Cited by 342 · see citing works
Toll-like receptors as targets in chronic liver diseases
Mencin, A. M., Kluwe, J., & Schwabe, R. F. (2009) · Gut · doi:10.1136/gut.2008.156307 · Cited by 328 · see citing works
Paudel, Y. N., Shaikh, M. F., Chakraborti, A., Kumari, Y., Aledo-Serrano, Á., Aleksovska, K., Alvim, M. K. M., & Othman, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00628 · Cited by 311 · see citing works
Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury
Roychowdhury, S., McMullen, M. R., Pisano, S. G., Liu, X., & Nagy, L. E. (2013) · Hepatology · doi:10.1002/hep.26200 · Cited by 304 · see citing works
Sato, S., St‐Pierre, C., Bhaumik, P., & Nieminen, J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00790.x · Cited by 298 · see citing works
Cauwe, B., & Opdenakker, G. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.501783 · Cited by 296 · see citing works
Hreggvidsdottir, H. S., Östberg, T., Wähämaa, H., Schierbeck, H., Aveberger, A.-C., Klevenvall, L., Palmblad, K., Ottosson, L., Andersson, U., & Harris, H. E. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908548 · Cited by 289 · see citing works
Rosin, D. L., & Okusa, M. D. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040430 · Cited by 284 · see citing works
Yang, H., Rivera, Z., Jube, S., Nasu, M., Bertino, P., Goparaju, C., Franzoso, G., Lotze, M. T., Krausz, T., Pass, H. I., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006542107 · Cited by 281 · see citing works
Self-citationInflammation in epileptogenesis after traumatic brain injury
Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R., & Semple, B. D. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0786-1 · Cited by 273 · see citing works
van Vliet, E. A., Aronica, E., Vezzani, A., & Ravizza, T. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12444 · Cited by 260 · see citing works
Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
Singh, S., Ornatowski, W., Vergne, I., Naylor, J., Delgado, M. A., Roberts, E. A., Ponpuak, M., Master, S. S., Pilli, M., White, E., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2119 · Cited by 257 · see citing works
Nuclear functions of the HMG proteins
Reeves, R. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.09.001 · Cited by 250 · see citing works
Parker, K. H., Sinha, P., Horn, L. A., Clements, V. K., Yang, H., Li, J., Tracey, K. J., & Ostrand‐Rosenberg, S. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2347 · Cited by 246 · see citing works
Receptor for Advanced Glycation End Products and Its Involvement in Inflammatory Diseases
Chuah, Y. K., Basir, R., Talib, H., Tie, T. H., & Nordin, N. (2013) · International Journal of Inflammation · doi:10.1155/2013/403460 · Cited by 243 · see citing works
Bianchi, R., Kastrisianaki, E., Giambanco, I., & Donato, R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.169342 · Cited by 241 · see citing works
Kim, S.-W., Jin, Y., Shin, J., Kim, I., Lee, H., Park, S., Han, P., & Lee, J.-K. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.056 · Cited by 240 · see citing works
Yun, N., Kang, J., & Lee, S. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.06.018 · Cited by 239 · see citing works
Perdiguero, E., Sousa-Victor, P., Ruiz-Bonilla, V., Jardí, M., Caelles, C., Serrano, A. L., & Muñoz-Cánoves, P. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201104053 · Cited by 236 · see citing works
The receptor RAGE: Bridging inflammation and cancer
Riehl, A., Németh, J., Angel, P. E., & Heß, J. (2009) · Cell Communication and Signaling · doi:10.1186/1478-811x-7-12 · Cited by 236 · see citing works
Crosstalk between ER stress and immunogenic cell death
Kepp, O., Menger, L., Vacchelli, E., Locher, C., Adjemian, S., Yamazaki, T., Martins, I., Sukkurwala, A. Q., Michaud, M., Senovilla, L., et al. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.001 · Cited by 233 · see citing works
Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α
Berda‐Haddad, Y., Robert, S., Salers, P., Zekraoui, L., Farnarier, C., Dinarello, C. A., Dignat‐George, F., & Kaplanski, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116848108 · Cited by 232 · see citing works
RAGE in tissue homeostasis, repair and regeneration
Sorci, G., Riuzzi, F., Giambanco, I., & Donato, R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.021 · Cited by 229 · see citing works
Innate immunity in cystic fibrosis lung disease
Hartl, D., Gaggar, A., Bruscia, E. M., Hector, A., Marcos, V., Jung, A., Greene, C. M., McElvaney, N. G., Mall, M. A., & Döring, G. (2012) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.07.003 · Cited by 227 · see citing works
The Neutrophil’s Choice: Phagocytose vs Make Neutrophil Extracellular Traps
Manfredi, A. A., Ramirez, G. A., Rovere, P. Q., & Maugeri, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00288 · Cited by 220 · see citing works
Self-citationLolmede, K., Campana, L., Vezzoli, M., Bosurgi, L., Tonlorenzi, R., Clementi, E., Bianchi, M. E., Cossu, G., Manfredi, A. A., Brunelli, S., et al. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908579 · Cited by 216 · see citing works
Self-citationEpilepsy and Inflammation in the Brain: Overview and Pathophysiology
Vezzani, A. (2014) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7511-14.s2.3 · Cited by 207 · see citing works
Peroxiredoxin 1 Stimulates Secretion of Proinflammatory Cytokines by Binding to TLR4
Riddell, J. R., Wang, X.-Y., Minderman, H., & Gollnick, S. O. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901945 · Cited by 206 · see citing works
Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development
Zurolo, E., Iyer, A., Maroso, M., Carbonell, C., Anink, J. J., Ravizza, T., Fluiter, K., Spliet, W. G. M., van Rijen, P. C., Vezzani, A., et al. (2011) · Brain · doi:10.1093/brain/awr032 · Cited by 184 · see citing works
Kain, V., Prabhu, S. D., & Halade, G. V. (2014) · Basic Research in Cardiology · doi:10.1007/s00395-014-0444-7 · Cited by 202 · see citing works
Lin, A. G., Truong, B., Patel, S. H., Kaushik, N. K., Choi, E. H., Fridman, G., Fridman, A., & Miller, V. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050966 · Cited by 201 · see citing works
Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue
Casula, M., Iyer, A. M., Spliet, W. G. M., Anink, J. J., Steentjes, K., Sta, M., Troost, D., & Aronica, E. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.001 · Cited by 200 · see citing works
From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection
Sharif, O., & Knapp, S. (2008) · Immunobiology · doi:10.1016/j.imbio.2008.07.008 · Cited by 196 · see citing works
Cell death, clearance and immunity in the skeletal muscle
Sciorati, C., Rigamonti, E., Manfredi, A. A., & Rovere, P. Q. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.171 · Cited by 194 · see citing works
Self-citationChemotherapy and radiotherapy: Cryptic anticancer vaccines
Ma, Y., Kepp, O., Ghiringhelli, F., Apétoh, L., Aymeric, L., Locher, C., Tesnière, A., Martins, I., Ly, A., Haynes, N. M., et al. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.03.001 · Cited by 193 · see citing works
Measles virus causes immunogenic cell death in human melanoma
Donnelly, O., Errington‐Mais, F., Steele, L. P., Hadac, E. M., Jennings, V. A., Scott, K. J., Peach, H., Phillips, R. M., Bond, J., Pandha, H., et al. (2011) · Gene Therapy · doi:10.1038/gt.2011.205 · Cited by 188 · see citing works
Pisetsky, D. S., Erlandsson-Harris, H., & Andersson, U. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2440 · Cited by 188 · see citing works
Dying cell clearance and its impact on the outcome of tumor radiotherapy
Lauber, K., Ernst, A., Orth, M., i, M. H., & Belka, C. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00116 · Cited by 186 · see citing works
Maroso, M., Balosso, S., Ravizza, T., Liu, J., Bianchi, M. E., & Vezzani, A. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02431.x · Cited by 182 · see citing works
Self-citationMazarati, A. M., Maroso, M., Iori, V., Vezzani, A., & Carli, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.012 · Cited by 182 · see citing works
Agalave, N. M., Larsson, M., Abdelmoaty, S., Su, J., Baharpoor, A., Lundbäck, P., Palmblad, K., Andersson, U., Harris, H. E., & Svensson, C. I. (2014) · Pain · doi:10.1016/j.pain.2014.06.007 · Cited by 179 · see citing works
A comparative review on European-farmed finfish RNA viruses and their vaccines
Gómez-Casado, E., Estepa, A., & Coll, J. M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.01.097 · Cited by 177 · see citing works
Cao, H., & Crocker, P. R. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03368.x · Cited by 172 · see citing works
Liikanen, I., Ahtiainen, L., Hirvinen, M., Bramante, S., Cerullo, V., Nokisalmi, P., Hemminki, O., Diaconu, I., Pesonen, S. A., Koski, A., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.51 · Cited by 165 · see citing works
Radiation as an Immune Modulator
Burnette, B., & Weichselbaum, R. R. (2013) · Seminars in Radiation Oncology · doi:10.1016/j.semradonc.2013.05.009 · Cited by 164 · see citing works
Balosso, S., Liu, J., Bianchi, M. E., & Vezzani, A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5349 · Cited by 161 · see citing works
Self-citationStress-induced glucocorticoids as a neuroendocrine alarm signal of danger
Frank, M. G., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.004 · Cited by 160 · see citing works
High Mobility Group Box-1 (HMGB1) Participates in the Pathogenesis of Alcoholic Liver Disease (ALD)
Ge, X., Antoine, D. J., Lu, Y., Arriazu, E., Leung, T.-M., Klepper, A. L., Branch, A. D., Fiel, M. I., & Nieto, N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.552141 · Cited by 160 · see citing works
Iori, V., Maroso, M., Rizzi, M., Iyer, A. M., Vertemara, R., Carli, M., Agresti, A., Antonelli, A., Bianchi, M. E., Aronica, E., et al. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.03.006 · Cited by 159 · see citing works
Self-citationTumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1
B, J. R. V. B., Nowak-Sliwinska, P. M., van den Boezem, E., Hautvast, P. A. I., Buurman, W. A., & Griffioen, A. W. (2012) · Oncogene · doi:10.1038/onc.2012.49 · Cited by 159 · see citing works
Toll-like Receptor 4 and Hepatic Fibrogenesis
Pradere, J.-P., Troeger, J., Dapito, D., Mencin, A., & Schwabe, R. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255353 · Cited by 158 · see citing works
Sim, S., Jupatanakul, N., Ramirez, J. L., Kang, S., Romero-Vivas, C. M., Mohammed, H. P., & Dimopoulos, G. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002295 · Cited by 157 · see citing works
Rider, P., Carmi, Y., Voronov, E., & Apte, R. N. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.005 · Cited by 155 · see citing works
Non-thermal plasma induces immunogenic cell deathin vivoin murine CT26 colorectal tumors
Lin, A. G., Xiang, B., Merlino, D. J., Baybutt, T. R., Sahu, J., Fridman, A., Snook, A. E., & Miller, V. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1484978 · Cited by 154 · see citing works
Kim, I., Shin, J., Kim, S.-W., Choi, S., Ahn, J., Han, P., Park, J. S., & Lee, J.-K. (2012) · Molecular Therapy · doi:10.1038/mt.2011.291 · Cited by 150 · see citing works
Bench-to-bedside review: Glucose and stress conditions in the intensive care unit
Losser, M.-R., Damoisel, C., & Payen, D. M. (2010) · Critical Care · doi:10.1186/cc9100 · Cited by 150 · see citing works
Influence of microbial environment on autoimmunity
Chervonsky, A. V. (2009) · Nature Immunology · doi:10.1038/ni.1801 · Cited by 147 · see citing works
Muire, P. J., Mangum, L. H., & Wenke, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01056 · Cited by 134 · see citing works
Arriazu, E., Ge, X., Leung, T.-M., Magdaleno, F., Lopategi, A., Lu, Y., Kitamura, N., Urtasun, R., Theise, N., Antoine, D. J., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310752 · Cited by 144 · see citing works
Kanellakis, P., Agrotis, A., Kyaw, T. S., Koulis, C., Ahrens, I., Mori, S., Takahashi, H. K., Liu, K., Peter, K., Nishibori, M., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.218669 · Cited by 144 · see citing works
Ge, X., Arriazu, E., Magdaleno, F., Antoine, D. J., Cruz, R. D., Theise, N. D., & Nieto, N. (2018) · Hepatology · doi:10.1002/hep.30093 · Cited by 142 · see citing works
The Janus face of HMGB1 in heart disease: a necessary update
Raucci, A., Maggio, S. D., Scavello, F., D’Ambrosio, A., Bianchi, M. E., & Capogrossi, M. C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2930-9 · Cited by 141 · see citing works
Self-citationCell Encapsulation Within Alginate Microcapsules: Immunological Challenges and Outlook
Ashimova, A., Yegorov, S., Negmetzhanov, B., & Hortelano, G. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00380 · Cited by 141 · see citing works
Jiang, M., Zeng, J., Zhao, L., Zhang, M., Ma, J., Guan, X., & Zhang, W. (2021) · Nanoscale · doi:10.1039/d1nr05512g · Cited by 140 · see citing works
HMGB1: a two-headed signal regulating tumor progression and immunity
Campana, L., Bosurgi, L., & Rovere, P. Q. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.04.012 · Cited by 138 · see citing works
RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease
Alexiou, P., Chatzopoulou, M., Pegklidou, K., & Demopoulos, V. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791331086 · Cited by 138 · see citing works
Pentraxins, humoral innate immunity and tissue injury
Manfredi, A. A., Rovere, P. Q., Bottazzi, B., Garlanda, C., & Mantovani, A. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.05.004 · Cited by 136 · see citing works
Self-citationFrye, B. C., Halfter, S., Djudjaj, S., Muehlenberg, P., Weber, S., Raffetseder, U., En‐Nia, A., Knott, H., Baron, J. M., Dooley, S., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.81 · Cited by 134 · see citing works
Regulation of Posttranslational Modifications of HMGB1 During Immune Responses
Tang, Y., Zhao, X. S., Antoine, D. J., Xiao, X., Wang, H., Andersson, U., Billiar, T. R., Tracey, K. J., & Lü, B. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6409 · Cited by 132 · see citing works
Krombach, J., Hennel, R., Brix, N., Orth, M., Schötz, U., Ernst, A., Schuster, J., Zuchtriegel, G., Reichel, C. A., Bierschenk, S., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1523097 · Cited by 132 · see citing works
Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside
Mishra, A., Bandopadhyay, R., Singh, P. K., Mishra, P. S., Sharma, N., & Khurana, N. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00806-4 · Cited by 132 · see citing works
Kim, I., Lim, C., Kim, J., Nam, H. Y., Nam, K., Kim, S.-W., Park, J., & Lee, J.-K. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.011 · Cited by 131 · see citing works
A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis
Scheeren, F. A., Kuo, A. H., van Weele, L. J., Cai, S., Glykofridis, I. E., Sikandar, S. S., Zabala, M., Qian, D., Lam, J. S., Johnston, D. M., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3058 · Cited by 131 · see citing works
Emerging Roles for HMGB1 Protein in Immunity, Inflammation, and Cancer
Ranzato, E., Martinotti, S., & Patrone, M. (2015) · ImmunoTargets and Therapy · doi:10.2147/itt.s58064 · Cited by 127 · see citing works
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Bağdaş, D., Gül, Z., Meade, J. A., Çam, B., Çinkılıç, N., & Gurun, M. S. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666191021111809 · Cited by 126 · see citing works
Campana, L., Bosurgi, L., Bianchi, M. E., Manfredi, A. A., & Rovere, P. Q. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0908576 · Cited by 124 · see citing works
Self-citationGene Silencing of NALP3 Protects Against Liver Ischemia–Reperfusion Injury in Mice
Zhu, P., Duan, L., Chen, J., Xiong, A., Xu, Q. L., Zhang, H., Zheng, F., Tan, Z., Gong, F., & Fang, M. (2010) · Human Gene Therapy · doi:10.1089/hum.2010.145 · Cited by 120 · see citing works
Innate immunity but not NLRP3 inflammasome activation correlates with severity of stable COPD
Stefano, A. D., Caramori, G., Barczyk, A., Vicari, C., Brun, P., Zanini, A., Cappello, F., Garofano, E., Padovani, A., Contoli, M., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2012-203062 · Cited by 119 · see citing works
- Authors
- Bianchi, M. E., & Manfredi, A. A.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Corresponding author
- Bianchi, Marco E.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2007-10-30
- Volume
- 220
- Issue
- 1
- Pages
- 35-46
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2109590683
- Cited by
- 600
- References
- 86
- Citations by year
- 2026: 13 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 28 · 2021: 21 · 2020: 17 · 2019: 25 · 2018: 41 · 2017: 34 · 2016: 26 · 2015: 37 · 2014: 44 · 2013: 55 · 2012: 45
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Associazione Italiana per la Ricerca sul Cancro
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Keywords
- HMGB1, high mobility group box 1, innate immunity, adaptive immunity, inflammation, tissue repair, dendritic cell maturation, T cell activation, autoimmunity, necrosis, chemokines, stem cell recruitment, autocrine and paracrine signaling
- MeSH terms
- Animals, Dendritic Cells, Humans, Immunity, Innate, Lupus Erythematosus, Systemic, T-Lymphocytes, Autoimmunity, Sepsis, HMGB1 Protein, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
