The DOI matches its Crossref record; 232 of the 232 references it cites were found in a registry or an index.
Importance of Cytokines in Murine Allergic Airway Disease and Human Asthma
Open accessAbstract
Asthma is a common, disabling inflammatory respiratory disease that has increased in frequency and severity in developed nations. We review studies of murine allergic airway disease (MAAD) and human asthma that evaluate the importance of Th2 cytokines, Th2 response-promoting cytokines, IL-17, and proinflammatory and anti-inflammatory cytokines in MAAD and human asthma. We discuss murine studies that directly stimulate airways with specific cytokines or delete, inactivate, neutralize, or block specific cytokines or their receptors, as well as controversial issues including the roles of IL-5, IL-17, and IL-13Rα2 in MAAD and IL-4Rα expression by specific cell types. Studies of human asthmatic cytokine gene and protein expression, linkage of cytokine polymorphisms to asthma, cytokine responses to allergen stimulation, and clinical responses to cytokine antagonists are discussed as well. Results of these analyses establish the importance of specific cytokines in MAAD and human asthma and have therapeutic implications.
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Cites
1 retracted
The Effects of a Monoclonal Antibody Directed against Tumor Necrosis Factor-α in Asthma
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Interleukin-13: Central Mediator of Allergic Asthma
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Transforming growth factor beta
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Cited by
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
CD4 + T-cell subsets in inflammatory diseases: beyond the T h 1/T h 2 paradigm
Hirahara, K., & Nakayama, T. (2016) · International Immunology · doi:10.1093/intimm/dxw006 · Cited by 417
Th9 cells: differentiation and disease
Kaplan, M. H. (2013) · Immunological Reviews · doi:10.1111/imr.12028 · Cited by 320
Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab
Ultsch, M., Bevers, J., Nakamura, G., Vandlen, R., Kelley, R. F., Wu, L. C., & Eigenbrot, C. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.024 · Cited by 174
The β-Glucan Receptor Dectin-1 Promotes Lung Immunopathology during Fungal Allergy via IL-22
Lilly, L. M., Gessner, M. A., Dunaway, C. W., Metz, A. E., Schwiebert, L., Weaver, C. T., Brown, G. D., & Steele, C. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201797 · Cited by 130
Metadata
- Authors
- Finkelman, F. D., Hogan, S. P., Hershey, G. K. K., Rothenberg, M. E., & Wills-Karp, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-01-27
- Volume
- 184
- Issue
- 4
- Pages
- 1663-1674
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2170299167
- Cited by
- 293
- References
- 232
- FWCI
- 23.02
- Type
- journal article
- Language
- en
- Open access
- green
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