The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses
Open accessAbstract
High expression of CXCR5 is one of the defining hallmarks of T follicular helper cells (TFH), a CD4 Th cell subset that promotes germinal center reactions and the selection and affinity maturation of B cells. CXCR5 is also expressed on 20–25% of peripheral blood human central memory CD4 T cells (TCM), although the definitive function of these cells is not fully understood. The constitutive expression of CXCR5 on TFH cells and a fraction of circulating TCM suggests that CXCR5+ TCM may represent a specialized subset of memory-type TFH cells programmed for homing to follicles and providing B cell help. To verify this assumption, we analyzed this cell population and show its specialized function in supporting humoral immune responses. Compared with their CXCR5− TCM counterparts, CXCR5+ TCM expressed high levels of the chemokine CXCL13 and efficiently induced plasma cell differentiation and Ig secretion. We found that the distinct B cell helper qualities of CXCR5+ TCM were mainly due to high ICOS expression and pronounced responsiveness to ICOS ligand costimulation together with large IL-10 secretion. Furthermore, B cell helper attributes of CXCR5+ TCM were almost exclusively acquired on cognate interaction with B cells, but not with dendritic cells. This implies that a preferential recruitment of circulating CXCR5+ TCM to CXCL13-rich B cell follicles is required for the promotion of a quick and efficient protective secondary humoral immune response. Taken together, we propose that CXCR5+ TCM represent a distinct memory cell subset specialized in supporting Ab-mediated immune responses.
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Cites
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Cited by
T follicular helper cell differentiation, function, and roles in disease
Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847
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In Vivo CD4 + T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm
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Metadata
- Authors
- Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G., & Mackay, C. R.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-05
- Volume
- 186
- Issue
- 10
- Pages
- 5556-5568
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2097289038
- Cited by
- 313
- References
- 81
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G., & Mackay, C. R. (2011). CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1002828
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
