The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing
Abstract
The human naive T cell repertoire is the repository of a vast array of TCRs. However, the factors that shape their hierarchical distribution and relationship with the memory repertoire remain poorly understood. In this study, we used polychromatic flow cytometry to isolate highly pure memory and naive CD8+ T cells, stringently defined with multiple phenotypic markers, and used deep sequencing to characterize corresponding portions of their respective TCR repertoires from four individuals. The extent of interindividual TCR sharing and the overlap between the memory and naive compartments within individuals were determined by TCR clonotype frequencies, such that higher-frequency clonotypes were more commonly shared between compartments and individuals. TCR clonotype frequencies were, in turn, predicted by the efficiency of their production during V(D)J recombination. Thus, convergent recombination shapes the TCR repertoire of the memory and naive T cell pools, as well as their interrelationship within and between individuals.
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Cites
A Direct Estimate of the Human αβ T Cell Receptor Diversity
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., & Kourilsky, P. (1999) · Science · doi:10.1126/science.286.5441.958 · Cited by 931
Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.
Nikolich-Žugich, J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2318 · Cited by 463 · cited 1×
“Overall, these data provide insights into the complex and dynamic relationship between the memory and naive T cell populations, which involves thymic output into the naive pool, homeostatic maintenance of the peripheral repertoire, and the ongoing recruitment of T cells from the naive pool during Ag encounter (7, 8, 4…”
BackgroundQuantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry
Chattopadhyay, P. K., Price, D. A., Harper, T. F., Betts, M. R., Yu, J., Gostick, E., Perfetto, S. P., Goepfert, P., Koup, R. A., De Rosa, S. C., et al. (2006) · Nature Medicine · doi:10.1038/nm1371 · Cited by 372
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Cited by
DNA methylation and epigenetic inheritance
Holliday, R. (1990) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1990.0015 · Cited by 2,279
Diversity and clonal selection in the human T-cell repertoire
Qi, Q., Liu, Y., Cheng, Y., Glanville, J., Zhang, D., Lee, J.-Y., Olshen, R. A., Weyand, C. M., Boyd, S. D., & Goronzy, J. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409155111 · Cited by 755
Using synthetic templates to design an unbiased multiplex PCR assay
Carlson, C. S., Emerson, R. O., Sherwood, A. M., Desmarais, C., Chung, M.-W., Parsons, J. M., Steen, M. S., LaMadrid-Herrmannsfeldt, M. A., Williamson, D. W., Livingston, R. J., et al. (2013) · Nature Communications · doi:10.1038/ncomms3680 · Cited by 565
Britanova, O. V., Putintseva, E. V., Shugay, M., Merzlyak, E. M., Turchaninova, M. A., Staroverov, D. B., Bolotin, D. A., Lukyanov, S., Bogdanova, E. A., Mamedov, I. Z., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302064 · Cited by 465
Krishna, C., DiNatale, R. G., Kuo, F., Srivastava, R. M., Vuong, L., Chowell, D., Gupta, S., Vanderbilt, C., Purohit, T. A., Liu, M., et al. (2021) · Cancer Cell · doi:10.1016/j.ccell.2021.03.007 · Cited by 432
Metadata
- Authors
- Venturi, V., Quigley, M. F., Greenaway, H. Y., Ng, P. C., Ende, Z. S., McIntosh, T., Asher, T. E., Almeida, J. R., Levy, S., Price, D. A., Davenport, M. P., & Douek, D. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-04-01
- Volume
- 186
- Issue
- 7
- Pages
- 4285-4294
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2123151433
- Cited by
- 178
- References
- 3
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
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- Venturi, V., Quigley, M. F., Greenaway, H. Y., Ng, P. C., Ende, Z. S., McIntosh, T., Asher, T. E., Almeida, J. R., Levy, S., Price, D. A., Davenport, M. P., & Douek, D. C. (2011). A Mechanism for TCR Sharing between T Cell Subsets and Individuals Revealed by Pyrosequencing. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1003898
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