Cited by 466T-cell and B-cell ImmunologyTelomeres, Telomerase, and SenescenceHIV Research and Treatment

Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections.

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Nikolich-Žugich, Janko·2008·Nature reviews. Immunology

Abstract

A diverse and well-balanced repertoire of T cells is thought to be crucial for the efficacious defence against infection with new or re-emerging pathogens throughout life. In the last third of the mammalian lifespan, the maintenance of a balanced T-cell repertoire becomes highly challenging because of the changes in T-cell production and consumption. In this Review, I question whether latent persistent pathogens might be key factors that drive this imbalance and whether they determine the extent of age-associated immune deficiency.

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Authors
Nikolich-Žugich, J.
Venue
Nature reviews. Immunology
Published
2008-07
Volume
8
Issue
7
Pages
512-522
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W1926141441
Cited by
463
References
128
Citations by year
2026: 23 · 2025: 28 · 2024: 18 · 2023: 26 · 2022: 28 · 2021: 30 · 2020: 24 · 2019: 17 · 2018: 28 · 2017: 20 · 2016: 21 · 2015: 24 · 2014: 35 · 2013: 35 · 2012: 23
FWCI
2.05
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (n01ai50027-8-0-1)
  • U.S. Public Health Service (N01 50027)
  • National Institute on Aging (AG 20719, AG23664, P01AG023664, AG 21384, R01AG020719, U01AG021384, R37AG020719)
  • National Institute of Allergy and Infectious Diseases (N01 AI050027)
  • National Center for Research Resources (RR-0163, P51RR000163, K01RR000163)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Keywords
immunosenescence, T cell homeostasis, T cell subsets, persistent viruses, T cell receptor repertoire, aging
MeSH terms
Aging, Animals, Cell Differentiation, Herpes Simplex, Homeostasis, Humans, Infections, Receptors, Antigen, T-Cell, Thymus Gland, T-Lymphocyte Subsets, Cellular Senescence

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