The Immunologic Release of Constituents from Neutrophil Leukocytes
Abstract
The interaction of rabbit neutrophils with immune complexes induced release of constitutents to the outside of the cell. Two situations were studied. In one, the neutrophils adhered to immune complexes dispersed along nonphagocytosable surfaces; in the other, the cells were allowed to engulf phagocytosable particles coated with antibody or complement. In each case, release of constituents from the neutrophil granules occurred. IgG antibody was as effective in stimulating release of enzymes as was C3, although they react with different receptors on the neutrophil membrane. Smaller quantities of immunologobulins were required to induce release if bound to the nonphagocytosable surface than if phagocytosed by the neutrophils in suspension.
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In frustrated phagocytosis, macrophages and foreign body giant cells can release mediators of degradation such as reactive oxygen intermediates, degradative enzymes, and acid into the privileged zone between the cell membrane and biomaterial surface, delaying or reducing immediate buffering or inhibition of these mediators.
“In a process described by Henson as frustrated phagocytosis, macrophages and foreign body giant cells can release mediators of degradation such as reactive oxygen intermediates (ROIs, oxygen free radicals), degradative enzymes, and acid into this privileged zone between the cell membrane and biomaterial surface such that immediate buffering or inhibition of these mediators is delayed or reduced.[”
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- Authors
- Henson, P. M.
- Affiliations
- Scripps Clinic (US)
- Corresponding author
- Henson, Peter M
- ORCID
- Henson, Peter M
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-12-01
- Volume
- 107
- Issue
- 6
- Pages
- 1535-1546
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W4313316314
- Cited by
- 347
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 9 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 10 · 2013: 6 · 2012: 2
- FWCI
- 3.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- neutrophils, immune complexes, IgG, complement C3, phagocytosis, antibody receptors, complement receptors, rabbit neutrophils
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