The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in Psoriasis
Open accessAbstract
γδ T cells mediate rapid tissue responses in murine skin and participate in cutaneous immune regulation including protection against cancer. The role of human γδ cells in cutaneous homeostasis and pathology is characterized poorly. In this study, we show in vivo evidence that human blood contains a distinct subset of proinflammatory cutaneous lymphocyte Ag and CCR6-positive Vγ9Vδ2 T cells, which is rapidly recruited into perturbed human skin. Vγ9Vδ2 T cells produced an array of proinflammatory mediators including IL-17A and activated keratinocytes in a TNF-α– and IFN-γ–dependent manner. Examination of the common inflammatory skin disease psoriasis revealed a striking reduction of circulating Vγ9Vδ2 T cells in psoriasis patients compared with healthy controls and atopic dermatitis patients. Decreased numbers of circulating Vγ9Vδ2 T cells normalized after successful treatment with psoriasis-targeted therapy. Taken together with the increased presence of Vγ9Vδ2 T cells in psoriatic skin, these data indicate redistribution of Vγ9Vδ2 T cells from the blood to the skin compartment in psoriasis. In summary, we report a novel human proinflammatory γδ T cell involved in skin immune surveillance with immediate response characteristics and with potential clinical relevance in inflammatory skin disease.
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Nestle, F. O., Kaplan, D. H., & Barker, J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804595 · Cited by 2,786
Self-citationγδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
Hayday, A. C. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.975 · Cited by 1,136
Self-citationPlasmacytoid predendritic cells initiate psoriasis through interferon-α production
Nestle, F. O., Conrad, C., Tun-Kyi, A., Homey, B., Gombert, M., Boyman, O., Burg, G., Liu, Y.-J., & Gilliet, M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050500 · Cited by 1,124
Self-citationRegulation of Cutaneous Malignancy by γδ T Cells
Girardi, M., Oppenheim, D. E., Steele, C. R., Lewis, J. M., Glusac, E., Filler, R., Hobby, P., Sutton, B., Tigelaar, R. E., & Hayday, A. C. (2001) · Science · doi:10.1126/science.1063916 · Cited by 1,004
Self-citationImmune surveillance in the skin: mechanisms and clinical consequences
Kupper, T. S., & Fuhlbrigge, R. C. (2004) · Nature Reviews Immunology · doi:10.1038/nri1310 · Cited by 805
The Vast Majority of CLA+ T Cells Are Resident in Normal Skin
Clark, R. A., Chong, B., Mirchandani, N., Brinster, N. K., Yamanaka, K.-I., Dowgiert, R. K., & Kupper, T. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.4431 · Cited by 796
Modlin, R. L., Pirmez, C., Hofman, F. M., Torigian, V., Uyemura, K., Rea, T. H., Bloom, B. R., & Brenner, M. B. (1989) · Nature · doi:10.1038/339544a0 · Cited by 580
γδ T Cells and the Lymphoid Stress-Surveillance Response
Hayday, A. C. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.006 · Cited by 495
Self-citationAntimicrobial peptides and the skin immune defense system
Schauber, J., & Gallo, R. L. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.03.027 · Cited by 477
Immunoregulation in the tissues by γδ T cells
Hayday, A., & Tigelaar, R. (2003) · Nature Reviews Immunology · doi:10.1038/nri1030 · Cited by 414
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Cited by
Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,650
Six-of-the-best: unique contributions of γδ T cells to immunology
Vantourout, P., & Hayday, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3384 · Cited by 1,232
Self-citationThe IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.11.005 · Cited by 537
Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in mice
Pantelyushin, S., Haak, S., Ingold, B., Kulig, P., Heppner, F. L., Navarini, A. A., & Becher, B. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61862 · Cited by 512
Villanova, F., Flutter, B., Tosi, I., Grys, K., Sreeneebus, H., Perera, G. K., Chapman, A., Smith, C. H., Di Meglio, P., & Nestle, F. O. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.477 · Cited by 386
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Metadata
- Authors
- Laggner, U., Di Meglio, P., Perera, G. K., Hundhausen, C., Lacy, K. E., Ali, N., Smith, C. H., Hayday, A. C., Nickoloff, B. J., & Nestle, F. O.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-09-01
- Volume
- 187
- Issue
- 5
- Pages
- 2783-2793
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2162298266
- Cited by
- 320
- References
- 41
- FWCI
- 11.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Laggner, U., Di Meglio, P., Perera, G. K., Hundhausen, C., Lacy, K. E., Ali, N., Smith, C. H., Hayday, A. C., Nickoloff, B. J., & Nestle, F. O. (2011). Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in Psoriasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1100804
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