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Cited by 125

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Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

Prado, Carolina, Contreras, Francisco, González, Hugo, Díaz, Pablo, Elgueta, Daniela, Barrientos, Magaly, Herrada, Andrés A, Lladser, Álvaro, Bernales, Sebastián, Pacheco, Rodrigo·2012·The Journal of Immunology
DOI 10.4049/jimmunol.1103096
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Abstract

Dendritic cells (DCs) are responsible for priming T cells and for promoting their differentiation from naive T cells into appropriate effector cells. Emerging evidence suggests that neurotransmitters can modulate T cell-mediated immunity. However, the involvement of specific neurotransmitters or receptors remains poorly understood. In this study, we analyzed the role of dopamine in the regulation of DC function. We found that DCs express dopamine receptors as well as the machinery necessary to synthesize, store, and degrade dopamine. Notably, the expression of D5R decreased upon LPS-induced DC maturation. Deficiency of D5R on the surface of DCs impaired LPS-induced IL-23 and IL-12 production and consequently attenuated the activation and proliferation of Ag-specific CD4+ T cells. To determine the relevance of D5R expressed on DCs in vivo, we studied the role of this receptor in the modulation of a CD4+ T cell-driven autoimmunity model. Importantly, D5R-deficient DCs prophylactically transferred into wild-type recipients were able to reduce the severity of experimental autoimmune encephalomyelitis. Furthermore, mice transferred with D5R-deficient DCs displayed a significant reduction in the percentage of Th17 cells infiltrating the CNS without differences in the percentage of Th1 cells compared with animals transferred with wild-type DCs. Our findings demonstrate that by contributing to CD4+ T cell activation and differentiation to Th17 phenotype, D5R expressed on DCs is able to modulate the development of an autoimmune response in vivo.

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Research works printed but not linked: 49

  1. Lanzavecchia, 2001, Regulation of T cell immunity by dendritic cells, Cell, 106, 263, 10.1016/S0092-8674(01)00455-X · DOI · Paper page
  2. Sakaguchi, 2004, Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses, Annu. Rev. Immunol., 22, 531, 10.1146/annurev.immunol.21.120601.141122 · DOI · Paper page
  3. McGeachy, 2008, Th17 cell differentiation: the long and winding road, Immunity, 28, 445, 10.1016/j.immuni.2008.03.001 · DOI · Paper page
  4. Banchereau, 2000, Immunobiology of dendritic cells, Annu. Rev. Immunol., 18, 767, 10.1146/annurev.immunol.18.1.767 · DOI · Paper page
  5. Pacheco, 2004, Group I metabotropic glutamate receptors mediate a dual role of glutamate in T cell activation, J. Biol. Chem., 279, 33352, 10.1074/jbc.M401761200 · DOI
  6. Pacheco, 2006, Glutamate released by dendritic cells as a novel modulator of T cell activation, J. Immunol., 177, 6695, 10.4049/jimmunol.177.10.6695 · DOI · Paper page
  7. León-Ponte, 2007, Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor, Blood, 109, 3139, 10.1182/blood-2006-10-052787 · DOI · Paper page
  8. O’Connell, 2006, A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells, Blood, 107, 1010, 10.1182/blood-2005-07-2903 · DOI · Paper page
  9. Grebe, 2009, Sympathetic nervous system control of anti-influenza CD8+ T cell responses, Proc. Natl. Acad. Sci. USA, 106, 5300, 10.1073/pnas.0808851106 · DOI
  10. Haskó, 1998, Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system, Biochem. Pharmacol., 56, 1079, 10.1016/S0006-2952(98)00153-1 · DOI · Paper page
  11. Weihe, 1991, Molecular anatomy of the neuro-immune connection, Int. J. Neurosci., 59, 1, 10.3109/00207459108985446 · DOI · Paper page
  12. Missale, 1998, Dopamine receptors: from structure to function, Physiol. Rev., 78, 189, 10.1152/physrev.1998.78.1.189 · DOI · Paper page
  13. Weihe, 2006, Three types of tyrosine hydroxylase-positive CNS neurons distinguished by dopa decarboxylase and VMAT2 co-expression, Cell. Mol. Neurobiol., 26, 659, 10.1007/s10571-006-9053-9 · DOI · Paper page
  14. Torres, 2003, Plasma membrane monoamine transporters: structure, regulation and function, Nat. Rev. Neurosci., 4, 13, 10.1038/nrn1008 · DOI · Paper page
  15. Mignini, 2009, Dopamine, vesicular transporters and dopamine receptor expression and localization in rat thymus and spleen, J. Neuroimmunol., 206, 5, 10.1016/j.jneuroim.2008.09.018 · DOI
  16. Mignini, 2006, Dopamine plasma membrane transporter (DAT) in rat thymus and spleen: an immunochemical and immunohistochemical study, Auton. Autacoid Pharmacol., 26, 183, 10.1111/j.1474-8673.2006.00370.x · DOI
  17. Alaniz, 1999, Dopamine beta-hydroxylase deficiency impairs cellular immunity, Proc. Natl. Acad. Sci. USA, 96, 2274, 10.1073/pnas.96.5.2274 · DOI
  18. Strange, 1993, New insights into dopamine receptors in the central nervous system, Neurochem. Int., 22, 223, 10.1016/0197-0186(93)90050-F · DOI
  19. Cosentino, 2000, HPLC-ED measurement of endogenous catecholamines in human immune cells and hematopoietic cell lines, Life Sci., 68, 283, 10.1016/S0024-3205(00)00937-1 · DOI
  20. Cosentino, 2007, Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop, Blood, 109, 632, 10.1182/blood-2006-01-028423 · DOI · Paper page
  21. Nakano, 2008, Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis, Biochem. Biophys. Res. Commun., 373, 286, 10.1016/j.bbrc.2008.06.012 · DOI
  22. Nakano, 2009, Dopamine released by dendritic cells polarizes Th2 differentiation, Int. Immunol., 21, 645, 10.1093/intimm/dxp033 · DOI
  23. Millan, 2001, The “selective” dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors, Psychopharmacology (Berl.), 156, 58, 10.1007/s002130100742 · DOI
  24. Briggs, 1991, Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393, Br. J. Pharmacol., 104, 1038, 10.1111/j.1476-5381.1991.tb12546.x · DOI
  25. Müller, 2009, 5-Hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo, PLoS ONE, 4, e6453, 10.1371/journal.pone.0006453 · DOI · Paper page
  26. Giorelli, 2005, Dopamine fails to regulate activation of peripheral blood lymphocytes from multiple sclerosis patients: effects of IFN-beta, J. Interferon Cytokine Res., 25, 395, 10.1089/jir.2005.25.395 · DOI
  27. Bałkowiec-Iskra, 2007, Dopamine, serotonin and noradrenaline changes in the striatum of C57BL mice following myelin oligodendrocyte glycoprotein (MOG) 35-55 and complete Freund adjuvant (CFA) administration, Acta Neurobiol. Exp. (Warsz.), 67, 379, 10.55782/ane-2007-1655 · DOI
  28. Hollon, 2002, Mice lacking D5 dopamine receptors have increased sympathetic tone and are hypertensive, J. Neurosci., 22, 10801, 10.1523/JNEUROSCI.22-24-10801.2002 · DOI · Paper page
  29. Ureta, 2007, Generation of dendritic cells with regulatory properties, Transplant. Proc., 39, 633, 10.1016/j.transproceed.2006.12.032 · doi:10.1016/j.transproceed.2006.12.032
  30. Inaba, 1992, Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor, J. Exp. Med., 176, 1693, 10.1084/jem.176.6.1693 · DOI · Paper page
  31. Uemura, 2008, Role of human non-invariant NKT lymphocytes in the maintenance of type 2 T helper environment during pregnancy, Int. Immunol., 20, 405, 10.1093/intimm/dxn001 · DOI
  32. González, 2008, Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells, Proc. Natl. Acad. Sci. USA, 105, 14999, 10.1073/pnas.0802555105 · DOI
  33. Mäkelä, 2009, Multiple signaling pathways contribute to synergistic TLR ligand-dependent cytokine gene expression in human monocyte-derived macrophages and dendritic cells, J. Leukoc. Biol., 85, 664, 10.1189/jlb.0808503 · DOI · Paper page
  34. Pacheco, 2009, Role of dopamine in the physiology of T-cells and dendritic cells, J. Neuroimmunol., 216, 8, 10.1016/j.jneuroim.2009.07.018 · DOI
  35. Kawashima, 2003, The lymphocytic cholinergic system and its contribution to the regulation of immune activity, Life Sci., 74, 675, 10.1016/j.lfs.2003.09.037 · DOI · Paper page
  36. Kawashima, 1998, Acetylcholine synthesis and muscarinic receptor subtype mRNA expression in T-lymphocytes, Life Sci., 62, 1701, 10.1016/S0024-3205(98)00131-3 · DOI
  37. Franco, 2007, The emergence of neurotransmitters as immune modulators, Trends Immunol., 28, 400, 10.1016/j.it.2007.07.005 · DOI
  38. Larsen, 2011, Dopamine transport by the serotonin transporter: a mechanistically distinct mode of substrate translocation, J. Neurosci., 31, 6605, 10.1523/JNEUROSCI.0576-11.2011 · DOI
  39. Metzger, 2002, Inhibitory effect of reserpine on dopamine transporter function, Eur. J. Pharmacol., 456, 39, 10.1016/S0014-2999(02)02647-X · DOI
  40. Goverman, 2009, Autoimmune T cell responses in the central nervous system, Nat. Rev. Immunol., 9, 393, 10.1038/nri2550 · DOI · Paper page
  41. Bourne, 2001, SCH 23390: the first selective dopamine D1-like receptor antagonist, CNS Drug Rev., 7, 399, 10.1111/j.1527-3458.2001.tb00207.x · DOI · Paper page
  42. Murphy, 2010, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain Behav. Immun., 24, 641, 10.1016/j.bbi.2010.01.014 · DOI · Paper page
  43. Matsushita, 2008, Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression, J. Clin. Invest., 118, 3420
  44. Pacheco, 2010, Emerging evidence for the role of neurotransmitters in the modulation of T cell responses to cognate ligands, Cent. Nerv. Syst. Agents Med. Chem., 10, 65, 10.2174/187152410790780154 · DOI
  45. Besser, 2005, Dopamine by itself activates either D2, D3 or D1/D5 dopaminergic receptors in normal human T-cells and triggers the selective secretion of either IL-10, TNFalpha or both, J. Neuroimmunol., 169, 161, 10.1016/j.jneuroim.2005.07.013 · DOI · Paper page
  46. Watanabe, 2006, Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3, J. Immunol., 176, 848, 10.4049/jimmunol.176.2.848 · DOI · Paper page
  47. McKenna, 2002, Dopamine receptor expression on human T- and B-lymphocytes, monocytes, neutrophils, eosinophils and NK cells: a flow cytometric study, J. Neuroimmunol., 132, 34, 10.1016/S0165-5728(02)00280-1 · DOI · Paper page
  48. Meredith, 2006, Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin’s lymphoma, Proc. Natl. Acad. Sci. USA, 103, 13485, 10.1073/pnas.0605993103 · DOI
  49. Kipnis, 2004, Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration, J. Neurosci., 24, 6133, 10.1523/JNEUROSCI.0600-04.2004 · DOI · Paper page

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Metadata

Authors
Prado, C., Contreras, F., González, H., Díaz, P., Elgueta, D., Barrientos, M., Herrada, A. A., Lladser, Á., Bernales, S., & Pacheco, R.
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2012-04-01
Volume
188
Issue
7
Pages
3062-3070
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1103096
Cited by
125
References
3
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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CoChat. (2026). Citation check: Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity. https://app.cochat.ai/papers/10.4049/jimmunol.1103096
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Prado, C., Contreras, F., González, H., Díaz, P., Elgueta, D., Barrientos, M., Herrada, A. A., Lladser, Á., Bernales, S., & Pacheco, R. (2012). Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1103096

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