Monocyte- and Macrophage-Targeted NADPH Oxidase Mediates Antifungal Host Defense and Regulation of Acute Inflammation in Mice
Open accessAbstract
Chronic granulomatous disease, an inherited disorder of the NADPH oxidase in which phagocytes are defective in the generation of superoxide anion and downstream reactive oxidant species, is characterized by severe bacterial and fungal infections and excessive inflammation. Although NADPH oxidase isoforms exist in several lineages, reactive oxidant generation is greatest in neutrophils, where NADPH oxidase has been deemed vital for pathogen killing. In contrast, the function and importance of NADPH oxidase in macrophages are less clear. Therefore, we evaluated susceptibility to pulmonary aspergillosis in globally NADPH oxidase–deficient mice versus transgenic mice with monocyte/macrophage-targeted NADPH oxidase activity. We found that the lethal inoculum was >100-fold greater in transgenic versus globally NADPH oxidase–deficient mice. Consistent with these in vivo results, NADPH oxidase in mouse alveolar macrophages limited germination of phagocytosed Aspergillus fumigatus spores. Finally, globally NADPH oxidase–deficient mice developed exuberant neutrophilic lung inflammation and proinflammatory cytokine responses to zymosan, a fungal cell wall–derived product composed principally of particulate β-glucans, whereas inflammation in transgenic and wild-type mice was mild and transient. Taken together, our studies identify a central role for monocyte/macrophage NADPH oxidase in controlling fungal infection and in limiting acute lung inflammation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Much of the discrepancy in the literature on killing of Aspergillus conidia by AMs is related to differences in study endpoints, methodology of killing assessment, moiety of infection, infection time points, NADPH oxidase knockout mouse strains, and method of immunosuppression.
“much of the discrepancy in the literature is related to differences in study endpoints (e.g., inhibition of growth versus killing), methodology of killing assessment (e.g., CFU plating versus conidial germination), moiety of infection, infection time points, NADPH oxidase knockout mouse strains, and method of immunosuppression used (203, 240–245).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [244]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y., Ueno, I., Sakamoto, A., Tong, K. I., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2021 · Cited by 2,422 · see citing works
Chronic Granulomatous Disease: Report on a National Registry of 368 Patients
Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728 · see citing works
Tlr signalling augments macrophage bactericidal activity through mitochondrial ros
West, A. P., Brodsky, I. E., Rahner, C., Woo, D. K., Erdjument-Bromage, H., Tempst, P., Walsh, M. C., Choi, Y., Shadel, G. S., & Ghosh, S. (2011) · Nature · doi:10.1038/nature09973 · Cited by 1,659 · see citing works
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,644 · see citing works
Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works
LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191 · see citing works
Killing activity of neutrophils is mediated through activation of proteases by K+ flux
Reeves, E. P., Lu, H., Jacobs, H. L., Messina, C. G. M., Bolsover, S., Gabella, G., Potma, E. O., Warley, A., Roes, J., & Segal, A. W. (2002) · Nature · doi:10.1038/416291a · Cited by 1,153 · see citing works
Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’
Goodridge, H. S., Reyes, C. N., Becker, C. A., Katsumoto, T. R., Ma, J., Wolf, A. J., Bose, N., Chan, A. S. H., Magee, A. S., Danielson, M. E., et al. (2011) · Nature · doi:10.1038/nature10071 · Cited by 871 · see citing works
Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Groß, O., Gewies, A., Finger, K., Schäfer, M., Sparwasser, T. D., Peschel, C., Förster, I., & Ruland, J. (2006) · Nature · doi:10.1038/nature04926 · Cited by 855 · see citing works
Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis
Savill, J., Dransfield, I., Hogg, N., & Haslett, C. (1990) · Nature · doi:10.1038/343170a0 · Cited by 846 · see citing works
A Homozygous <i>CARD9</i> Mutation in a Family with Susceptibility to Fungal Infections
Glocker, E.-O., Hennigs, A., Nabavi, M., Schäffer, A. A., Woellner, C., Salzer, U., Pfeifer, D., Veelken, H., Warnatz, K., Tahami, F., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810719 · Cited by 800 · see citing works
Surface hydrophobin prevents immune recognition of airborne fungal spores
Aimanianda, V., Bayry, J., Bozza, S., Kniemeyer, O., Perruccio, K., Elluru, S. R., Clavaud, C., Paris, S., Brakhage, A. A., Kaveri, S. V., et al. (2009) · Nature · doi:10.1038/nature08264 · Cited by 792 · see citing works
Human dectin-1 deficiency and mucocutaneous fungal infections
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901053 · Cited by 752 · see citing works
Chronic Granulomatous Disease: The European Experience
van den Berg, J. M., van Koppen, E., Åhlin, A., Belohradsky, B. H., Bernatowska, E. A., Corbeel, L., Español, T., Fischer, A., Kurenko-Deptuch, M., Mouy, R., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005234 · Cited by 685 · see citing works
Segal, B. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808853 · Cited by 659 · see citing works
Self-citationCoxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627 · see citing works
Schaffner, A., Douglas, H., & Braude, A. I. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110489 · Cited by 618 · see citing works
Restoration of NET formation by gene therapy in CGD controls aspergillosis
Bianchi, M., Hakkim, A., Brinkmann, V., Siler, U., Seger, R. A., Zychlinsky, A., & Reichenbach, J. (2009) · Blood · doi:10.1182/blood-2009-05-221606 · Cited by 593 · see citing works
Residual NADPH Oxidase and Survival in Chronic Granulomatous Disease
Kuhns, D. B., Alvord, W. G., Heller, T., Feld, J. J., Pike, K. M., Marciano, B. E., Uzel, G., DeRavin, S. S., Priel, D. A. L., Soule, B. P., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1007097 · Cited by 568 · see citing works
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Romani, L., Fallarino, F., De Luca, A., Montagnoli, C., D’Angelo, C., Zelante, T., Vacca, C., Bistoni, F., Fioretti, M. C., Grohmann, U., et al. (2008) · Nature · doi:10.1038/nature06471 · Cited by 535 · see citing works
Self-citationThe Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., & Brown, G. D. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010042 · Cited by 509 · see citing works
The p47phox mouse knock-out model of chronic granulomatous disease.
Jackson, S. H., Gallin, J. I., & Holland, S. M. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.751 · Cited by 484 · see citing works
Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display
Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M., & Pamer, E. G. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010030 · Cited by 428 · see citing works
Self-citationGastrointestinal Involvement in Chronic Granulomatous Disease
Marciano, B. E., Rosenzweig, S. D., Kleiner, D. E., Anderson, V., Darnell, D. N., Anaya‐O’Brien, S., Hilligoss, D. M., Malech, H. L., Gallin, J. I., & Holland, S. M. (2004) · PEDIATRICS · doi:10.1542/peds.114.2.462 · Cited by 417 · see citing works
Philippe, B., Ibrahim-Granet, O., Prévost, M. C., Gougerot-Pocidalo, M. A., Sanchez Perez, M., Van der Meeren, A., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3034-3042.2003 · Cited by 415 · see citing works
Requisite Role for the Dectin-1 β-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus
Werner, J. L., Metz, A. E., Horn, D., Schoeb, T. R., Hewitt, M. M., Schwiebert, L. M., Faro‐Trindade, I., Brown, G. D., & Steele, C. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804250 · Cited by 412 · see citing works
Morgenstern, D. E., Gifford, M. A. C., Li, L. L., Doerschuk, C. M., & Dinauer, M. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.2.207 · Cited by 370 · see citing works
Hultqvist, M. H., Olofsson, P., Holmberg, J., Bäckström, B. T., Tordsson, J. M., & Holmdahl, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403831101 · Cited by 343 · see citing works
Self-citationGersuk, G. M., Underhill, D. M., Zhu, L., & Marr, K. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3717 · Cited by 334 · see citing works
Bustamante, J., Arias, A. A., Vogt, G., Picard, C., Galicia, L. B., Prando, C., Grant, A. V., Marchal, C. C., Hubeau, M., Chapgier, A., et al. (2011) · Nature Immunology · doi:10.1038/ni.1992 · Cited by 287 · see citing works
Gelderman, K. A., Hultqvist, M. H., Pizzolla, A., Zhao, M. F., Nandakumar, K. S., Mattsson, R., & Holmdahl, R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31935 · Cited by 239 · see citing works
Self-citationNrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice
Cho, H., Gladwell, W., Wang, X., Chorley, B. N., Bell, D. A., Reddy, S. P., & Kleeberger, S. R. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200907-1047oc · Cited by 227 · see citing works
Fujita, K.-I., Maeda, D., Xiao, Q., & Srinivasula, S. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014156108 · Cited by 225 · see citing works
Mircescu, M. M., Lipuma, L., van Rooijen, N., Pamer, E. G., & Hohl, T. M. (2009) · The Journal of Infectious Diseases · doi:10.1086/600380 · Cited by 216 · see citing works
Self-citationThe Prolonged Life-Span of Alveolar Macrophages
Murphy, J., Summer, R. S., Wilson, A. A., Kotton, D. N., & Fine, A. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0224rc · Cited by 196 · see citing works
Wasylnka, J. A., & Moore, M. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3156-3163.2002 · Cited by 188 · see citing works
Zarember, K. A., Sugui, J. A., Chang, Y. C., Kwon-Chung, K. J., & Gallin, J. I. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.10.6367 · Cited by 184 · see citing works
Berenguer, J., Allende, M. C., Lee, J. W., Garrett, K., Lyman, C., Ali, N. M., Bacher, J., Pizzo, P. A., & Walsh, T. J. (1995) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.152.3.7663787 · Cited by 183 · see citing works
NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice
Segal, B. H., Han, W., Bushey, J. J., Joo, M., Bhatti, Z., Feminella, J., Dennis, C. G., Vethanayagam, R. R., Yull, F. E., Capitano, M. L., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009631 · Cited by 180 · see citing works
Self-citationBonnett, C. R., Cornish, E. J., Harmsen, A. G., & Burritt, J. B. (2006) · Infection and Immunity · doi:10.1128/iai.00909-06 · Cited by 174 · see citing works
Fungal antioxidant pathways promote survival against neutrophils during infection
Leal, S. M., Vareechon, C., Cowden, S., Cobb, B. A., Latgé, J.-P., Momany, M., & Pearlman, E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63239 · Cited by 146 · see citing works
Fernandez-Boyanapalli, R. F., Frasch, S. C., McPhillips, K. A., Vandivier, R. W., Harry, B. L., Riches, D. W. H., Henson, P. M., & Bratton, D. L. (2008) · Blood · doi:10.1182/blood-2008-05-160564 · Cited by 133 · see citing works
Shi, C., Sakuma, M., Mooroka, T., Liscoe, A., Gao, H., Croce, K., Sharma, A., Kaplan, D. R., Greaves, D. R., Wang, Y., et al. (2008) · Blood · doi:10.1182/blood-2008-01-137018 · Cited by 130 · see citing works
Normal and Deficient Neutrophils Can Cooperate to Damage Aspergillus fumigatus Hyphae
Rex, J. H., Bennett, J., Gallin, J. I., Malech, H. L., & Melnick, D. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.2.523 · Cited by 124 · see citing works
Roilides, E., Dimitriadou, A., Kadiltsoglou, I., Sein, T., Karpouzas, J., Pizzo, P. A., & Walsh, T. J. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.1.322 · Cited by 122 · see citing works
Jhingran, A., Mar, K. B., Kumasaka, D. K., Knoblaugh, S. E., Ngo, L. Y., Segal, B. H., Iwakura, Y., Lowell, C. A., Hamerman, J. A., Lin, X., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.026 · Cited by 119 · see citing works
Self-citationPizzolla, A., Hultqvist, M., Nilson, B., Grimm, M. J., Eneljung, T., Jonsson, I.-M., Verdrengh, M., Kelkka, T., Gjertsson, I., Segal, B. H., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103430 · Cited by 108 · see citing works
Self-citationFrasch, S. C., Fernandez-Boyanapalli, R. F., Berry, K. A. Z., Leslie, C. C., Bonventre, J. V., Murphy, R. C., Henson, P. M., & Bratton, D. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.181800 · Cited by 102 · see citing works
Lykens, J. E., Terrell, C. E., Zoller, E. E., Divanovic, S., Trompette, A., Karp, C. L., Aliberti, J., Flick, M. J., & Jordan, M. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902346 · Cited by 102 · see citing works
Fernandez-Boyanapalli, R., Frasch, S. C., Riches, D. W. H., Vandivier, R. W., Henson, P. M., & Bratton, D. L. (2010) · Blood · doi:10.1182/blood-2010-02-272005 · Cited by 98 · see citing works
A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils
Geering, B., Gurzeler, U., Federzoni, E. A., Kaufmann, T., & Simon, H. (2011) · Blood · doi:10.1182/blood-2010-11-322206 · Cited by 93 · see citing works
Luca, A. D., Iannitti, R. G., Bozza, S., Beau, R., Casagrande, A., D’Angelo, C., Moretti, S., Cunha, C., Giovannini, G., Massi-Benedetti, C., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60862 · Cited by 77 · see citing works
Dennis, C. G., Greco, W. R., Brun, Y. F., Youn, R. C., Slocum, H. K., Bernacki, R. J., Lewis, R. E., Wiederhold, N. P., Holland, S. M., Petraitienė, R., et al. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.2.422-427.2006 · Cited by 69 · see citing works
Self-citationBoyle, K. B., Győri, D., Sindrilaru, A., Scharffetter‐Kochanek, K., Taylor, P. R., Mócsai, A., Stephens, L., & Hawkins, P. T. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002268 · Cited by 64 · see citing works
Identification of a region in p47phox/NCF1 crucial for phagocytic NADPH oxidase (NOX2) activation
Sareila, O., Jaakkola, N., Olofsson, P., Kelkka, T., & Holmdahl, R. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.1211588 · Cited by 61 · see citing works
Self-citationRole of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense
Vethanayagam, R. R., Almyroudis, N. G., Grimm, M. J., Lewandowski, D. C., Pham, C. T. N., Blackwell, T. S., Petraitienė, R., Petraitis, V., Walsh, T. J., Urban, C. F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028149 · Cited by 59 · see citing works
Self-citationSchäppi, M. G., Deffert, C., Fiette, L., Gavazzi, G., Herrmann, F. R., Belli, D. C., & Krause, K. (2007) · The Journal of Pathology · doi:10.1002/path.2298 · Cited by 59 · see citing works
Deffert, C., Carnésecchi, S., Yuan, H., Rougemont, A., Kelkka, T., Holmdahl, R., Krause, K., & Schäppi, M. G. (2012) · The Journal of Pathology · doi:10.1002/path.4061 · Cited by 57 · see citing works
Self-citationSantosuosso, M., Divangahi, M., Zganiacz, A., et al. (2002) · Blood · doi:10.1182/blood.v99.4.1246 · Cited by 54 · see citing works
Segal, B. H., Sakamoto, N., Patel, M. B., Maemura, K., Klein, A. S., Holland, S. M., & Bulkley, G. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.4.2374-2378.2000 · Cited by 50 · see citing works
Self-citationNADPH Oxidase and Nrf2 Regulate Gastric Aspiration–Induced Inflammation and Acute Lung Injury
Davidson, B. A., Vethanayagam, R. R., Grimm, M. J., Mullan, B. A., Raghavendran, K., Blackwell, T. S., Freeman, M. L., Vanniarajan, A., Singh, K. K., Sporn, M. B., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202410 · Cited by 50 · see citing works
Self-citationCornish, E. J., Hurtgen, B. J., McInnerney, K., Burritt, N. L., Taylor, R. M., Jarvis, J. N., Wang, S. Y., & Burritt, J. B. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6854 · Cited by 48 · see citing works
Monocytes Recruited to the Lungs of Mice during Immune Inflammation Ingest Apoptotic Cells Poorly
Jennings, J. H., Linderman, D. J., Hu, B., Sonstein, J., & Curtis, J. L. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0108oc · Cited by 36 · see citing works
Davidson, B. A., Stewart, C. C., Russo, T. A., et al. (2005) · Experimental Lung Research · doi:10.1080/01902140590918524 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [41]Pizzolla A Hultqvist M Nilson B Grimm MJ Eneljung T Jonsson IM Verdrengh M Kelkka T Gjertsson I Segal BH Holmdahl R 2012 Reactive Oxygen Species Produced by the NADPH Oxidase 2 Complex in Monocytes Protect Mice from Bacterial Infections J Immunol PMC3566649 22491245
Cited by
Sorted by citations
Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Latgé, J.-P., Beauvais, A., & Chamilos, G. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-030117-020406 · Cited by 207 · see citing works
Type III interferon is a critical regulator of innate antifungal immunity
Espinosa, V., Dutta, O., McElrath, C., Du, P., Chang, Y.-J., Cicciarelli, B., Pitler, A., Whitehead, I., Obar, J. J., Durbin, J. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aan5357 · Cited by 202 · see citing works
Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation
Holmdahl, R., Sareila, O., Olsson, L. M., Bäckdahl, L., & Wing, K. (2016) · Immunological Reviews · doi:10.1111/imr.12378 · Cited by 131 · see citing works
Self-citationAntifungal innate immunity: recognition and inflammatory networks
Becker, K. L., Ifrim, D. C., Quintin, J., Netea, M. G., & van de Veerdonk, F. L. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0467-z · Cited by 86 · see citing works
Shepardson, K. M., Jhingran, A., Caffrey, A., Obar, J. J., Suratt, B. T., Berwin, B. L., Hohl, T. M., & Cramer, R. A. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004378 · Cited by 79 · see citing works
Self-citationDesoubeaux, G., & Cray, C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00841 · Cited by 55 · see citing works
- Authors
- Grimm, M. J., Vethanayagam, R. R., Almyroudis, N. G., Dennis, C. G., Khan, A. N. H., D’Auria, A. C., Singel, K. L., Davidson, B. A., Knight, P. R., Blackwell, T. S., Hohl, T. M., Mansour, M. K., Vyas, J. M., Röhm, M., Urban, C. F., Kelkka, T., Holmdahl, R., & Segal, B. H.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- University at Buffalo, State University of New York (US)
- Vanderbilt University (US)
- Fred Hutch Cancer Center (US)
- Harvard University (US)
- Umeå University (SE)
- University of Turku (FI)
- Corresponding author
- Kelkka, Tiina
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04
- Volume
- 190
- Issue
- 8
- Pages
- 4175-4184
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3622122
- OpenAlex
- W1576281382
- Cited by
- 81
- References
- 65
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 11 · 2014: 8 · 2013: 4
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- European Commission (223404)
- Academy of Finland
- National Heart, Lung, and Blood Institute (R01HL048889)
- National Cancer Institute (CA016056., P30CA016056)
- National Institute of Allergy and Infectious Diseases (R01AI092084, R01AI079253, R37AI093808, T32AI007061)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- NADPH oxidase, monocytes, alveolar macrophages, pulmonary aspergillosis, Aspergillus fumigatus, chronic granulomatous disease, acute lung inflammation, zymosan, β-glucan, reactive oxygen species, superoxide, transgenic mice, neutrophilic inflammation
- MeSH terms
- Acute Disease, Animals, Aspergillosis, Aspergillus fumigatus, Inflammation, Lung, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Zymosan, Macrophages, Alveolar, Mice, Knockout, NADPH Oxidases, Genetic Predisposition to Disease, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
