Dectin-1 and TLRs Permit Macrophages to Distinguish between Different Aspergillus fumigatus Cellular States
Abstract
Aspergillus fumigatus is a common cause of invasive and allergic pulmonary disease. Resting conidia of the filamentous fungus are constantly inhaled, but cause infection only after initiating hyphal growth. In this study, we have explored whether macrophages can distinguish between resting spores and the maturing, potentially invasive form of the fungus. Although macrophages bind and ingest A. fumigatus resting conidia efficiently, there is little inflammatory response; NF-κβ is not activated, inflammatory cytokines are not induced, and reactive oxygen species are not produced. However, maturing A. fumigatus conidia and germ tubes stimulate NF-κβ, secretion of proinflammatory cytokines and production of reactive oxygen by human monocyte-derived macrophages and murine macrophages from multiple anatomical sites. These responses are in part mediated by dectin-1, which binds cell wall β-glucan that is not present on the surface of dormant conidia, but is present after cellular swelling and loss of the hydrophobic proteinaceous cell wall. Dectin-1 binding to germ tubes augments, but is not required for, TLR2-mediated inflammatory cytokine secretion. Dectin-1 recognition of germ tubes also stimulates TNF-α production in the absence of both TLR2 and MyD88 signaling. These data demonstrate one mechanism by which the pulmonary inflammatory response is tailored toward metabolically active cells, thereby avoiding unnecessary tissue damage with frequent inhalation of ubiquitous spores.
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The discovery of selective activation of Dectin-1/Syk signaling during germination of Aspergillus conidia due to stage-specific surface exposure of β-glucan and the ability of PRR to regulate phagosome maturation provided the conceptual framework of PAMPs masking as a mechanism employed by fungi to escape macrophage killing.
“The discovery of selective activation of Dectin-1/Syk signaling during germination of Aspergillus conidia due to stage-specific surface exposure of β-glucan (194, 246, 247) and the ability of PRR to regulate phagosome maturation (248) provided the conceptual framework of pathogen-associated molecular patterns (PAMPs) masking as a mechanism employed by fungi to escape macrophage killing.”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [247]
Cites
<i>Aspergillus fumigatus</i> and Aspergillosis
Latgé, J.-P. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.310 · Cited by 2,307 · see citing works
Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2
Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., & Underhill, D. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021787 · Cited by 1,644 · see citing works
Self-citationBrown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
Dectin-1 Mediates the Biological Effects of β-Glucans
Brown, G. D., Herre, J., Williams, D. L., Willment, J. A., Marshall, A. S. J., & Gordon, S. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021890 · Cited by 1,209 · see citing works
Dectin‐1 mediates macrophage recognition of Candida albicans yeast but not filaments
Gantner, B. N., Simmons, R. M., & Underhill, D. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600594 · Cited by 671 · see citing works
Self-citationNon-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., et al. (2002) · Nature · doi:10.1038/nature01195 · Cited by 669 · see citing works
The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus
Steele, C., Rapaka, R. R., Metz, A., Pop, S. M., Williams, D. L., Gordon, S., Kolls, J. K., & Brown, G. D. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010042 · Cited by 509 · see citing works
Molecular Organization of the Alkali-insoluble Fraction ofAspergillus fumigatus Cell Wall
Fontaine, T., Simenel, C., Dubreucq, G., Adam, O., Delepierre, M., Lemoine, J., Vorgias, C. E., Diaquin, M., & Latgé, J.-P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909975199 · Cited by 436 · see citing works
Aspergillus fumigatus Triggers Inflammatory Responses by Stage-Specific β-Glucan Display
Hohl, T. M., Van Epps, H. L., Rivera, A., Morgan, L. A., Chen, P. L., Feldmesser, M., & Pamer, E. G. (2005) · PLoS Pathogens · doi:10.1371/journal.ppat.0010030 · Cited by 428 · see citing works
Philippe, B., Ibrahim-Granet, O., Prévost, M. C., Gougerot-Pocidalo, M. A., Sanchez Perez, M., Van der Meeren, A., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3034-3042.2003 · Cited by 415 · see citing works
Palma, A. S., Feizi, T., Zhang, Y.-B., Stoll, M. S., Lawson, A. M., Díaz-Rodríguez, E., Campanero‐Rhodes, M. A., Costa, J., Gordon, S., Brown, G. D., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m511461200 · Cited by 375 · see citing works
Bozza, S., Gaziano, R., Spreca, A., Bacci, A., Montagnoli, C., Francesco, P. D., & Romani, L. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1362 · Cited by 331 · see citing works
Marr, K. A., Patterson, T. F., & Denning, D. W. (2002) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00035-1 · Cited by 310 · see citing works
Self-citationMeier, A., Kirschning, C. J., Nikolaus, T., Wagner, H., Heesemann, J., & Ebel, F. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00301.x · Cited by 297 · see citing works
Toll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus
Mambula, S. S., Sau, K., Henneke, P., Golenbock, D. T., & Levitz, S. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201683200 · Cited by 297 · see citing works
Steele, C. H., Marrero, L., Swain, S., Harmsen, A. G., Zheng, M., Brown, G. D., Gordon, S., Shellito, J. E., & Kolls, J. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030932 · Cited by 289 · see citing works
Netea, M. G., Warris, A., van der Meer, J. W. M., Fenton, M. J., Verver-Jansen, T. J. G., Jacobs, L., Andresen, T. K., Verweij, P. E., & Kullberg, B. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/376456 · Cited by 284 · see citing works
<i>Aspergillus fumigatus</i> cell wall: composition and biosynthesis
Bernard, M., & Latgé, J.-P. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.9.17 · Cited by 282 · see citing works
Phagocytosis and Intracellular Fate of<i>Aspergillus fumigatus</i>Conidia in Alveolar Macrophages
Ibrahim-Granet, O., Philippe, B., Boleti, H., Boisvieux-Ulrich, E., Grenet, D., Stern, M., & Latgé, J. P. (2003) · Infection and Immunity · doi:10.1128/iai.71.2.891-903.2003 · Cited by 277 · see citing works
Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis.
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · PubMed · Cited by 264 · see citing works
Role of TNF-α in Pulmonary Host Defense in Murine Invasive Aspergillosis
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1633 · Cited by 244 · see citing works
Conidial Hydrophobins ofAspergillus fumigatus
Paris, S., Debeaupuis, J. P., Crameri, R., Carey, M., Charlès, F., Prévost, M. C., Schmitt, C., Philippe, B., & Latgé, J. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.3.1581-1588.2003 · Cited by 235 · see citing works
Serrano-Gómez, D., Domínguez-Soto, A., Ancochea, J., Jimenez-Heffernan, J. A., Leal, J. A., & Corbí, A. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.9.5635 · Cited by 218 · see citing works
Glucan Synthase Complex of <i>Aspergillus fumigatus</i>
Beauvais, A., Bruneau, J. M., Mol, P. C., Buitrago, M. J., Legrand, R., & Latgé, J. P. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.7.2273-2279.2001 · Cited by 209 · see citing works
Viriyakosol, S., Fierer, J., Brown, G. D., & Kirkland, T. N. (2005) · Infection and Immunity · doi:10.1128/iai.73.3.1553-1560.2005 · Cited by 181 · see citing works
Aspergillus fumigatus antigens activate innate immune cells via toll‐like receptors 2 and 4
Braedel-Ruoff, S., Radsak, M. P., Einsele, H., Latgé, J., Michan, A., Loeffler, J., Haddad, Z., Grigoleit, U., Schild, H., & Hebart, H. F. (2004) · British Journal of Haematology · doi:10.1111/j.1365-2141.2004.04922.x · Cited by 180 · see citing works
Liebmann, B., Müller, M., Braun, A. C., & Brakhage, A. A. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5193-5203.2004 · Cited by 167 · see citing works
Differential Role of MyD88 in Macrophage-Mediated Responses to Opportunistic Fungal Pathogens
Marr, K. A., Balajee, S. A., Hawn, T. R., Ozinsky, A., Pham, U., Akira, S., Aderem, A. A., & Liles, W. C. (2003) · Infection and Immunity · doi:10.1128/iai.71.9.5280-5286.2003 · Cited by 129 · see citing works
Self-citationHume, D. A., Underhill, D. M., Sweet, M. J., Ozinsky, A., Liew, F. Y., & Aderem, A. A. (2001) · BMC Immunology · doi:10.1186/1471-2172-2-11 · Cited by 126 · see citing works
Self-citationDistinct CD4+-T-Cell Responses to Live and Heat-InactivatedAspergillus fumigatusConidia
Rivera, A., Epps, H. L. V., Hohl, T. M., Rizzuto, G. A., & Pamer, E. G. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7170-7179.2005 · Cited by 88 · see citing works
Kan, V. L., & Bennett, J. E. (1988) · The Journal of Infectious Diseases · doi:10.1093/infdis/158.2.407 · Cited by 78 · see citing works
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Aspergillus fumigatus and Aspergillosis in 2019
Latgé, J.-P., & Chamilos, G. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00140-18 · Cited by 1,400 · see citing works
Dectin-1 is required for β-glucan recognition and control of fungal infection
Taylor, P. R., Tsoni, S. V., Willment, J. A., Dennehy, K. M., Rosas, M., Findon, H., Haynes, K., Steele, C. H., Botto, M., Gordon, S., et al. (2006) · Nature Immunology · doi:10.1038/ni1408 · Cited by 1,155 · see citing works
Pathogenesis of <i>Aspergillus fumigatus</i> in Invasive Aspergillosis
Dagenais, T. R. T., & Keller, N. P. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00055-08 · Cited by 993 · see citing works
Infections Caused by <i>Scedosporium</i> spp
Cortez, K. J., Roilides, E., Quiroz-Telles, F., Meletiadis, J., Antachopoulos, C., Knudsen, T., Buchanan, W., Milanovich, J., Sutton, D. A., Fothergill, A., et al. (2008) · Clinical Microbiology Reviews · doi:10.1128/cmr.00039-07 · Cited by 786 · see citing works
Dyken, S. J. V., & Locksley, R. M. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095906 · Cited by 714 · see citing works
The mycobiota: interactions between commensal fungi and the host immune system
Underhill, D. M., & Iliev, I. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3684 · Cited by 692 · see citing works
Self-citationβ‐glucan recognition by the innate immune system
Goodridge, H. S., Wolf, A. J., & Underhill, D. M. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00793.x · Cited by 693 · see citing works
Self-citationSegal, B. H. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808853 · Cited by 659 · see citing works
Luther, K., Torosantucci, A., Brakhage, A. A., Heesemann, J., & Ebel, F. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00796.x · Cited by 582 · see citing works
Martínez‐Pomares, L. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0512231 · Cited by 540 · see citing works
Fungi and allergic lower respiratory tract diseases
Knutsen, A. P., Bush, R. K., Demain, J. G., Denning, D. W., Dixit, A., Fairs, A., Greenberger, P. A., Kariuki, B., Kita, H., Kurup, V. P., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.970 · Cited by 486 · see citing works
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
Bochud, P.-Y., Chien, J. W., Marr, K. A., Leisenring, W. M., Upton, A., Janer, M., Rodrigues, S. D., Li, S., Hansen, J. A., Zhao, L. P., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802629 · Cited by 453 · see citing works
Self-citationRappleye, C. A., Eissenberg, L. G., & Goldman, W. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609848104 · Cited by 419 · see citing works
Requisite Role for the Dectin-1 β-Glucan Receptor in Pulmonary Defense against Aspergillus fumigatus
Werner, J. L., Metz, A. E., Horn, D., Schoeb, T. R., Hewitt, M. M., Schwiebert, L. M., Faro‐Trindade, I., Brown, G. D., & Steele, C. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804250 · Cited by 412 · see citing works
Goodridge, H. S., Simmons, R. M., & Underhill, D. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.3107 · Cited by 359 · see citing works
Self-citationC-type lectins and phagocytosis
Kerrigan, A. M., & Brown, G. D. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.11.003 · Cited by 325 · see citing works
Sadier, N. S., Padilla, E., Langsley, G., & Ojcius, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010008 · Cited by 302 · see citing works
The role of Dectin-1 in the host defence against fungal infections
Drummond, R. A., & Brown, G. D. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.07.001 · Cited by 294 · see citing works
Mucosal immune responses to infection and vaccination in the respiratory tract
Mettelman, R. C., Allen, E. K., & Thomas, P. G. (2022) · Immunity · doi:10.1016/j.immuni.2022.04.013 · Cited by 272 · see citing works
C-type lectin receptors in antifungal immunity
Willment, J. A., & Brown, G. D. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.10.012 · Cited by 268 · see citing works
Eduard, W. (2009) · Critical Reviews in Toxicology · doi:10.3109/10408440903307333 · Cited by 251 · see citing works
Dectin-1 Signaling Update: New Perspectives for Trained Immunity
Mata-Martínez, P., Bergón-Gutiérrez, M., & del Fresno, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.812148 · Cited by 243 · see citing works
<i>Aspergillus fumigatus</i> : Principles of Pathogenesis and Host Defense
Hohl, T. M., & Feldmesser, M. (2007) · Eukaryotic Cell · doi:10.1128/ec.00274-07 · Cited by 237 · see citing works
Sub-Telomere Directed Gene Expression during Initiation of Invasive Aspergillosis
McDonagh, A., Fedorova, N. D., Crabtree, J., Yu, Y., Kim, H. S., Chen, D., Loss, O., Cairns, T. C., Goldman, G. H., Armstrong-James, D. P. H., et al. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000154 · Cited by 232 · see citing works
Innate Immunity toAspergillusSpecies
Park, S. J., & Mehrad, B. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-09 · Cited by 230 · see citing works
Jouault, T., Behi, M. E. A.-E., Martínez-Esparza, M., Breuilh, L., Trinel, P., Chamaillard, M., Trottein, F., & Poulain, D. (2006) · Journal of Immunology · doi:10.4049/jimmunol.177.7.4679 · Cited by 256 · see citing works
Advances in combating fungal diseases: vaccines on the threshold
Cutler, J. E., Deepe, G. S., & Klein, B. S. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1537 · Cited by 223 · see citing works
Mircescu, M. M., Lipuma, L., van Rooijen, N., Pamer, E. G., & Hohl, T. M. (2009) · The Journal of Infectious Diseases · doi:10.1086/600380 · Cited by 216 · see citing works
NOX2-dependent regulation of inflammation
Singel, K. L., & Segal, B. H. (2016) · Clinical Science · doi:10.1042/cs20150660 · Cited by 214 · see citing works
Latgé, J.-P., Beauvais, A., & Chamilos, G. (2017) · Annual Review of Microbiology · doi:10.1146/annurev-micro-030117-020406 · Cited by 207 · see citing works
Tsoni, S. V., & Brown, G. D. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1443.019 · Cited by 207 · see citing works
Aspergillosis: Spectrum of Disease, Diagnosis, and Treatment
Barnes, P. D., & Marr, K. A. (2006) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2006.06.001 · Cited by 205 · see citing works
Self-citationImmunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
Batbayar, S., Lee, D.-H., & Kim, H.-W. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.5.433 · Cited by 192 · see citing works
Collaboration between the innate immune receptors dectin‐1, TLRs, and Nods
Underhill, D. M. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00548.x · Cited by 187 · see citing works
Self-citationThe innate immune response to Aspergillus fumigatus
Balloy, V., & Chignard, M. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.07.002 · Cited by 187 · see citing works
Lamaris, G. A., Lewis, R. E., Chamilos, G., May, G. S., Safdar, A., Walsh, T. J., RAAD, I. I., & Kontoyiannis, D. P. (2008) · The Journal of Infectious Diseases · doi:10.1086/589305 · Cited by 186 · see citing works
Hyphal Growth in Human Fungal Pathogens and Its Role in Virulence
Brand, A. (2011) · International Journal of Microbiology · doi:10.1155/2012/517529 · Cited by 180 · see citing works
Distinct Roles for Dectin-1 and TLR4 in the Pathogenesis of Aspergillus fumigatus Keratitis
Leal, S. M., Cowden, S., Hsia, Y. C., Ghannoum, M. A., Momany, M., & Pearlman, E. M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000976 · Cited by 179 · see citing works
Pathogenic Fungal Infection in the Lung
Li, Z., Lu, G., & Meng, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01524 · Cited by 176 · see citing works
Bonnett, C. R., Cornish, E. J., Harmsen, A. G., & Burritt, J. B. (2006) · Infection and Immunity · doi:10.1128/iai.00909-06 · Cited by 174 · see citing works
Immune responses to commensal and environmental microbes
Pamer, E. G. (2007) · Nature Immunology · doi:10.1038/ni1526 · Cited by 169 · see citing works
The role of the β-glucan receptor Dectin-1 in control of fungal infection
Dennehy, K. M., & Brown, G. D. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1206753 · Cited by 165 · see citing works
Loures, F. V., Röhm, M., Lee, C. K., Santos, E., Wang, J. P., Specht, C. A., Calich, V. L. G., Urban, C. F., & Levitz, S. M. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004643 · Cited by 165 · see citing works
Kerrigan, A. M., & Brown, G. D. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00882.x · Cited by 161 · see citing works
MAP kinase pathways as regulators of fungal virulence
Román, E., Arana, D. M., Nombela, C., Alonso‐Monge, R., & Plá, J. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.02.001 · Cited by 158 · see citing works
Rivera, A., Hohl, T. M., Collins, N., Leiner, I. M., Gallegos, A. M., Saijo, S., Coward, J., Iwakura, Y., & Pamer, E. G. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100906 · Cited by 155 · see citing works
Tissue‐resident innate immunity in the lung
Ardain, A., Marakalala, M. J., & Leslie, A. J. (2019) · Immunology · doi:10.1111/imm.13143 · Cited by 142 · see citing works
Aspergillus fumigatus Conidial Melanin Modulates Host Cytokine Response
Chai, L. Y. A., Netea, M. G., Sugui, J. A., Vonk, A. G., van de Sande, W. W. J., Warris, A., Kwon-Chung, K. J., & Kullberg, B. J. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.10.002 · Cited by 141 · see citing works
The Interaction of Human Pathogenic Fungi With C-Type Lectin Receptors
Goyal, S., Castrillón-Betancur, J. C., Klaile, E., & Slevogt, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01261 · Cited by 142 · see citing works
Rosas, M., Liddiard, K., Kimberg, M., Faro‐Trindade, I., McDonald, J. U., Williams, D. L., Brown, G. D., & Taylor, P. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3549 · Cited by 139 · see citing works
Regulation of innate immunity by NADPH oxidase
Segal, B. H., Grimm, M. J., Khan, A. N. H., Han, W., & Blackwell, T. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.022 · Cited by 139 · see citing works
Interaction of phagocytes with filamentous fungi
Brakhage, A. A., Bruns, S., Thywißen, A., Zipfel, P. F., & Behnsen, J. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.04.009 · Cited by 136 · see citing works
Innate Immune Activation and CD4+ T Cell Priming during Respiratory Fungal Infection
Rivera, A., Ro, G. S., Epps, H. L. V., Simpson, T. R., Leiner, I. M., Sant’Angelo, D. B., & Pamer, E. G. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.016 · Cited by 135 · see citing works
Chamilos, G., Ganguly, D., Lande, R., Gregorio, J. D., Meller, S., Goldman, W. E., Gilliet, M. F., & Kontoyiannis, D. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012955 · Cited by 131 · see citing works
Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans
Stuehler, C., Khanna, N., Bozza, S., Zelante, T., Moretti, S., Kruhm, M., Lurati, S., Conrad, B., Worschech, E., Stevanović, S., et al. (2011) · Blood · doi:10.1182/blood-2010-12-325084 · Cited by 131 · see citing works
Fungal Chitin from Asthma-Associated Home Environments Induces Eosinophilic Lung Infiltration
Dyken, S. J. V., Garcia, D. A., Porter, P., Huang, X., Quinlan, P. J., Blanc, P. D., Corry, D. B., & Locksley, R. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100972 · Cited by 131 · see citing works
Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street
Underhill, D. M., & Pearlman, E. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.023 · Cited by 130 · see citing works
Self-citationThe innate immune response to Aspergillus fumigatus at the alveolar surface
Margalit, A., & Kavanagh, K. A. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv018 · Cited by 129 · see citing works
Cell wall α1-3glucans induce the aggregation of germinating conidia of Aspergillus fumigatus
Fontaine, T., Beauvais, A., Loussert, C., Thevenard, B., Fulgsang, C. C., Ohno, N., Clavaud, C., Prevost, M.-C., & Latgé, J.-P. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.04.006 · Cited by 126 · see citing works
Chai, L. Y. A., van de Veerdonk, F. L., Marijnissen, R. J., Cheng, S., Khoo, A. L., Hectors, M. P. C., Lagrou, K., Vonk, A. G., Maertens, J. A., Joosten, L. A. B., et al. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03211.x · Cited by 124 · see citing works
Interference of Aspergillus fumigatus with the immune response
Heinekamp, T., Schmidt, H., Lapp, K., Pähtz, V., Shopova, I., Köster-Eiserfunke, N., Krüger, T., Kniemeyer, O., & Brakhage, A. A. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-014-0465-1 · Cited by 123 · see citing works
Jhingran, A., Mar, K. B., Kumasaka, D. K., Knoblaugh, S. E., Ngo, L. Y., Segal, B. H., Iwakura, Y., Lowell, C. A., Hamerman, J. A., Lin, X., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.026 · Cited by 119 · see citing works
Hohl, T. M., Feldmesser, M., Perlin, D. S., & Pamer, E. G. (2008) · The Journal of Infectious Diseases · doi:10.1086/589304 · Cited by 119 · see citing works
Bhatia, S., Fei, M., Yarlagadda, M., Qi, Z., Akira, S., Saijo, S., Iwakura, Y., van Rooijen, N., Gibson, G. A., Croix, C. M. S., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015943 · Cited by 119 · see citing works
Fungi in the cystic fibrosis lung: Bystanders or pathogens?
Chotirmall, S. H., & McElvaney, N. G. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.03.001 · Cited by 113 · see citing works
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing
Rosowski, E. E., Raffa, N., Knox, B. P., Golenberg, N., Keller, N. P., & Anna Huttenlocher, A. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007229 · Cited by 113 · see citing works
Leal, S. M., Roy, S., Vareechon, C., Carrion, S. D., Clark, H., Lopez-Berges, M. S., diPietro, A., Schrettl, M., Beckmann, N., Redl, B., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003436 · Cited by 111 · see citing works
Pathogenicity and virulence of Aspergillus fumigatus
Earle, K., Valero, C., Conn, D. P., Vere, G., Cook, P. C., Bromley, M., Bowyer, P., & Gago, S. (2023) · Virulence · doi:10.1080/21505594.2023.2172264 · Cited by 117 · see citing works
Dubourdeau, M., Athman, R., Balloy, V., Huerre, M., Chignard, M., Philpott, D. J., Latgé, J., & Ibrahim-Granet, O. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.6.3994 · Cited by 111 · see citing works
Aspergillus-Associated Airway Disease, Inflammation, and the Innate Immune Response
Chotirmall, S. H., Al‐Alawi, M., Mirković, B., Lavelle, G., Logan, P. M., Greene, C. M., & McElvaney, N. G. (2013) · BioMed Research International · doi:10.1155/2013/723129 · Cited by 109 · see citing works
Fungal glycans and the innate immune recognition
Barreto‐Bergter, E., & Figueiredo, R. T. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00145 · Cited by 110 · see citing works
Microbial Phagocytic Receptors and Their Potential Involvement in Cytokine Induction in Macrophages
Fu, Y., & Harrison, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.662063 · Cited by 109 · see citing works
Woehrle, T., Du, W., Goetz, A., Hsu, H., Joos, T. O., Weiss, M., Bauer, U. U. I., Brueckner, U. B., & Schneider, E. M. (2008) · Cytokine · doi:10.1016/j.cyto.2007.12.006 · Cited by 109 · see citing works
Jhingran, A., Kasahara, S., Shepardson, K. M., Junecko, B. A. F., Heung, L. J., Kumasaka, D. K., Knoblaugh, S. E., Lin, X., Kazmierczak, B. I., Reinhart, T. A., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004589 · Cited by 108 · see citing works
Fungal Recognition by TLR2 and Dectin-1
Goodridge, H. S., & Underhill, D. M. (2007) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-72167-3_5 · Cited by 105 · see citing works
Self-citationPulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications
Sherif, R. D., & Segal, B. H. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328337d6de · Cited by 106 · see citing works
β-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner
Shah, V. B., Huang, Y., Keshwara, R., Ozment-Skelton, T. R., Williams, D. L., & Keshvara, L. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2777 · Cited by 104 · see citing works
Immune responses against Aspergillus fumigatus
Cramer, R. A., Rivera, A., & Hohl, T. M. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328348b159 · Cited by 99 · see citing works
Modulation of Toll-Like Receptor 2 (TLR2) and TLR4 Responses byAspergillus fumigatus
Chai, L. Y. A., Kullberg, B. J., Vonk, A. G., Warris, A., Cambi, A., Latgé, J., Joosten, L. A. B., van der Meer, J. W. M., & Netea, M. G. (2009) · Infection and Immunity · doi:10.1128/iai.01455-08 · Cited by 101 · see citing works
Slesiona, S., Gressler, M., Mihlan, M., Zaehle, C., Schaller, M., Barz, D., Hube, B., Jacobsen, I. D., & Brock, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031223 · Cited by 98 · see citing works
The role of dectin-1 in health and disease
Kalia, N., Singh, J., & Kaur, M. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152071 · Cited by 97 · see citing works
Mezger, M., Kneitz, S., Wozniok, I., Kurzai, O., Einsele, H., & Loeffler, J. (2008) · The Journal of Infectious Diseases · doi:10.1086/528694 · Cited by 97 · see citing works
The role of the cell wall in fungal pathogenesis
Arana, D. M., Prieto, D., Román, E., Nombela, C., Alonso‐Monge, R., & Pla, J. (2009) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00070.x · Cited by 92 · see citing works
Cell mediated immunity to fungi: a reassessment
Romani, L. R. (2008) · Medical Mycology · doi:10.1080/13693780801971450 · Cited by 96 · see citing works
Targeting CBLB as a potential therapeutic approach for disseminated candidiasis
Xiao, Y., Tang, J., Guo, H., Zhao, Y., Tang, R., Ouyang, S., Zeng, Q., Rappleye, C. A., Rajaram, M. V. S., Schlesinger, L. S., et al. (2016) · Nature Medicine · doi:10.1038/nm.4141 · Cited by 92 · see citing works
Immune Correlates of Protection in Human Invasive Aspergillosis
Camargo, J. F., & Husain, S. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu337 · Cited by 91 · see citing works
Knox, B. P., Deng, Q., Rood, M., Eickhoff, J. C., Keller, N. P., & Anna Huttenlocher, A. (2014) · Eukaryotic Cell · doi:10.1128/ec.00080-14 · Cited by 88 · see citing works
Healthy Human T-Cell Responses to Aspergillus fumigatus Antigens
Chaudhary, N., Staab, J. F., & Marr, K. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009036 · Cited by 89 · see citing works
Self-citationClinical reviews in allergy and immunology
Leung, D. Y. M., Ledford, D. K., Wechsler, M. E., Fulkerson, P. C., Bochner, B. S., Gauvreau, G. M., Gleich, G. J., Henkel, T., Kolbeck, R., Mathur, S. K., et al. (2012) · Cited by 87 · see citing works
Smith, A. J., Graves, B. M., Child, R., Rice, P. J., Ma, Z., Lowman, D. W., Ensley, H. E., Ryter, K. T., Evans, J. T., & Williams, D. L. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701258 · Cited by 86 · see citing works
Impact of Aspergillus fumigatus in allergic airway diseases
Chaudhary, N., & Marr, K. A. (2011) · Clinical and Translational Allergy · doi:10.1186/2045-7022-1-4 · Cited by 86 · see citing works
Self-citationThe protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A
Serezani, A. P. M., Cavassani, K. A., Ismailoglu, U. B., Hullinger, R., Dunleavy, M. P., Knight, D. A., Kunkel, S. L., Uematsu, S., Akira, S., & Hogaboam, C. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44999 · Cited by 83 · see citing works
Alekseeva, L. G., Huet, D., Féménia, F., Mouyna, I., Abdelouahab, M., Cagna, A., Guerrier, D., Seltzer, V., Baeza‐Squiban, A., Chermette, R., et al. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-33 · Cited by 83 · see citing works
Victor, E. S., Karnam, A., Fontaine, T., Beauvais, A., Das, M., Hegde, P., Prakhar, P., Holla, S., Balaji, K. N., Kaveri, S. V., et al. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix469 · Cited by 84 · see citing works
Pathogenic Fungus Microsporum canis Activates the NLRP3 Inflammasome
Mao, L., Zhang, L., Li, H., Chen, W., Wang, H., Wu, S., Guo, C., Lu, A., Yang, G., An, L., et al. (2013) · Infection and Immunity · doi:10.1128/iai.01097-13 · Cited by 82 · see citing works
Minireview: host defence in invasive aspergillosis
Lass‐Flörl, C., Roilides, E., Löffler, J., Wilflingseder, D., & Romani, L. R. (2013) · Mycoses · doi:10.1111/myc.12052 · Cited by 81 · see citing works
Contact, Collaboration, and Conflict: Signal Integration of Syk-Coupled C-Type Lectin Receptors
Ostrop, J., & Lang, R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601665 · Cited by 80 · see citing works
Grimm, M. J., Vethanayagam, R. R., Almyroudis, N. G., Dennis, C. G., Khan, A. N. H., D’Auria, A. C., Singel, K. L., Davidson, B. A., Knight, P. R., Blackwell, T. S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202800 · Cited by 81 · see citing works
Chaudhary, N., Datta, K., Askin, F. B., Staab, J. F., & Marr, K. A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201106-1027oc · Cited by 79 · see citing works
Self-citationIbrahim-Granet, O., Jouvion, G., Hohl, T. M., Droin-Bergère, S., Philippart, F., Kim, O., Adib‐Conquy, M., Schwendener, R. A., Cavaillon, J., & Brock, M. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-105 · Cited by 78 · see citing works
- Authors
- Gersuk, G. M., Underhill, D. M., Zhu, L., & Marr, K. A.
- Affiliations
- University of Washington (US)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Zhu, Liqun
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03
- Volume
- 176
- Issue
- 6
- Pages
- 3717-3724
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1562117121
- Cited by
- 334
- References
- 31
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 14 · 2017: 22 · 2016: 16 · 2015: 18 · 2014: 23 · 2013: 15 · 2012: 16
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM62995, R01GM062995)
- National Institute of Allergy and Infectious Diseases (R01 AI51468, R01AI051468)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- Aspergillus fumigatus, Dectin-1, TLR2, macrophages, germ tube, conidia, β-glucan, NF-κB, TNF-α, reactive oxygen species, inflammatory cytokines, lung inflammation, fungal pathogenesis, MyD88, innate immunity
- MeSH terms
- Dectin-1, Animals, Aspergillus fumigatus, Cell Differentiation, Cells, Cultured, Humans, Inflammation, Macrophages, Membrane Proteins, Nerve Tissue Proteins, Protein Binding, Tumor Necrosis Factor-alpha, Lectins, C-Type, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice
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