Cited by 131Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressSystemic Lupus Erythematosus Research

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

Holmdahl, Rikard, Sareila, Outi, Olsson, Lina M., Bäckdahl, Liselotte, Wing, Kajsa·2016·Immunological Reviews

Abstract

Summary: The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced reactive oxygen species (ROS) is based on a genetic search for the major genes controlling autoimmune inflammatory disorders. Surprisingly, the disease‐promoting allele determined a lower ROS response and was therefore in complete contrast to the prevailing dogma. Once cloned, it opened the possibility to dissect this complex field from a new angle and with the possibilities to study the role of ROS in vivo. We found that NCF1 and NADPH oxidase 2 (NOX 2) complex‐derived ROS is an important regulator of several chronic inflammatory disorders by using models for rheumatoid arthritis, multiple sclerosis, psoriasis and psoriasis arthritis, gout, and lupus. ROS could therefore affect many different types of diseases and the common denominator seems to be that ROS regulate macrophages, which prevents inflammation from going chronic. The role of ROS is currently changing from being seen as toxic agents that will promote inflammation toward a more complex view with ROS as crucial regulators of immune and inflammatory pathways.

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Registry

Crossref · 10.1111/imr.12378

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  • Phagocytes can release O2•− both into the phagosome and the extracellular space due to expression of NOX2 on both the phagosome and the plasma membrane.

    “Phagocytes can release O2•− both into the phagosome and the extracellular space due to expression of NOX2 on both the phagosome and the plasma membrane [174].”

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Authors
Holmdahl, R., Sareila, O., Olsson, L. M., Bäckdahl, L., & Wing, K.
Affiliations
  • University of Turku (FI)
  • Karolinska Institutet (SE)
Corresponding author
Holmdahl, Rikard
Venue
Immunological Reviews
Publisher
Wiley
Published
2015-12-19
Volume
269
Issue
1
Pages
228-247
ISSN
  • 0105-2896 (ISSN-L)
  • 1600-065X
OpenAlex
W2200658189
Cited by
131
References
147
Citations by year
2026: 7 · 2025: 6 · 2024: 8 · 2023: 10 · 2022: 18 · 2021: 14 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 18 · 2016: 10 · 2015: 1
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Immunological Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Stiftelsen för Strategisk Forskning
  • Knut och Alice Wallenbergs Stiftelse
  • Seventh Framework Programme
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords
NCF1, NADPH oxidase 2, reactive oxygen species, rheumatoid arthritis, multiple sclerosis, psoriasis, psoriatic arthritis, gout, lupus, macrophages, genetic susceptibility
MeSH terms
NADPH Oxidase 2, Animals, Autoimmune Diseases, Humans, Inflammation, Membrane Glycoproteins, Oxidation-Reduction, Polymorphism, Genetic, Reactive Oxygen Species, NADPH Oxidases, Genetic Predisposition to Disease

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