Innate Immunity and Its Regulation by Mast Cells
Open accessAbstract
Mast cells (MCs), which are granulated tissue-resident cells of hematopoietic lineage, constitute a major sensory arm of the innate immune system. In this review we discuss the evidence supporting the dual role of MCs, both as sentinels for invading pathogens and as regulatory cells throughout the course of acute inflammation, from its initiation to resolution. This versatility is dependent on the ability of MCs to detect pathogens and danger signals and release a unique panel of mediators to promote pathogen-specific clearance mechanisms, such as through cellular recruitment or vascular permeability. It is increasingly understood that MCs also contribute to the regulated contraction of immune activation that occurs within tissues as inflammation resolves. This overarching regulatory control over innate immune processes has made MCs successful targets to purposefully enhance or, alternatively, suppress MC responses in multiple therapeutic contexts.
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- Authors
- St. John, A. L., & Abraham, S. N.
- Affiliations
- Program in Emerging Infectious Diseases, Duke–National University of Singapore , Singapore 169857
- National University of Singapore (SG)
- ORCID
- Abraham, Soman N
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-05-01
- Volume
- 190
- Issue
- 9
- Pages
- 4458-4463
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3645001
- OpenAlex
- W1893318402
- Cited by
- 220
- References
- 84
- Citations by year
- 2026: 3 · 2025: 16 · 2024: 12 · 2023: 13 · 2022: 7 · 2021: 22 · 2020: 17 · 2019: 15 · 2018: 21 · 2017: 20 · 2016: 22 · 2015: 17 · 2014: 30 · 2013: 4 · 2012: 1
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL112921)
- National Institute on Drug Abuse (R21DA029731)
- National Institute of Allergy and Infectious Diseases (U01AI082107, R01AI096305)
- National Institute of Diabetes and Digestive and Kidney Diseases (R56DK095198, R01DK101456, R01DK077159, R37DK050814, R21DK077307)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- mast cells, innate immunity, acute inflammation, inflammation resolution, pathogen detection, damage-associated molecular patterns, mast cell mediators, vascular permeability, immune cell recruitment, mast cell-targeted therapy
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Mast Cells
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