The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN-γ+CD4+ T Cell Numbers during Colitis Development in Mice
Open accessAbstract
The spleen regulatory B cell subset with the functional capacity to express IL-10 (B10 cells) modulates both immune responses and autoimmune disease severity. However, the peritoneal cavity also contains relatively high frequencies of functionally defined IL-10–competent B10 cells. In this study, peritoneal cavity B10 cells shared similar cell surface phenotypes with their spleen counterparts. However, peritoneal cavity B10 cells were 10-fold more frequent among B cells than occurred within the spleen, intestinal tract, or mesenteric lymph nodes and were present at higher proportions among the phenotypically defined peritoneal B1a > B1b > B2 cell subpopulations. The development or localization of B10 cells within the peritoneal cavity was not dependent on the presence of commensal microbiota, T cells, IL-10 or B10 cell IL-10 production, or differences between their fetal liver or adult bone marrow progenitor cell origins. The BCR repertoire of peritoneal cavity B10 cells was diverse, as occurs in the spleen, and predominantly included germline-encoded VH and VL regions commonly found in either the conventional or B1 B cell compartments. Thereby, the capacity to produce IL-10 appears to be an intrinsic functional property acquired by clonally diverse B cells. Importantly, IL-10 production by peritoneal cavity B cells significantly reduced disease severity in spontaneous and induced models of colitis by regulating neutrophil infiltration, colitogenic CD4+ T cell activation, and proinflammatory cytokine production during colitis onset. Thus, the numerically small B10 cell subset within the peritoneal cavity has regulatory function and is important for maintaining homeostasis within gastrointestinal tissues and the immune system.
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“The proportion of Bregs ranges from 1 to 3% of total B cells in the spleen and peritoneal cavity of healthy mice, whereas in humans, Bregs typically constitute 1 -4% of circulating B cells under homeostatic conditions [57,59,60].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [60]
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Citations
Cites
Interleukin-10 and the Interleukin-10 Receptor
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“T cells, B cells, monocytes, macrophages, mast cells, and eosinophils can all secrete IL-10 that suppresses inflammatory cytokine production, Th1/Th2 polarization, and Ag presentation (5, 13, 14).”
BackgroundThe gut microbiota shapes intestinal immune responses during health and disease
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“Given that T cells also play critical regulatory roles during IBD development in mice, as well as in humans (1, 3), it is likely that B10 and regulatory Foxp3+ CD4+ T cells share complementary regulatory functions for IBD, as previously shown for experimental autoimmune encephalomyelitis (29).”
BackgroundInfluentialMultiple sequence alignment with the Clustal series of programs
Chenna, R. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg500 · Cited by 4,905 · cited 1×
“VH-D-JH and VK-JK transcript alignments and phylogenetic trees based on average percent identity were constructed using ClustalW2 (45).”
MethodInterleukin-10-deficient mice develop chronic enterocolitis
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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
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“Rag2 and 10BiT reporter mice were as described (39, 40).”
MethodIL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866 · cited 1×
“T cells, B cells, monocytes, macrophages, mast cells, and eosinophils can all secrete IL-10 that suppresses inflammatory cytokine production, Th1/Th2 polarization, and Ag presentation (5, 13, 14).”
BackgroundAsseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617 · cited 2×
“That peritoneal cavity B10 cells can alter the development and severity of colitis was further verified using the inducible T cell– transfer model of colitis (10).”
BackgroundRegulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586
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“B10 cells represent a small and functionally distinct B cell subset that shares some overlapping phenotypic markers with multiple B cell subpopulations, including spleen B1 cells, marginal zone progenitor cells, marginal zone cells, memory cells and plasmablasts (23, 24, 46, 51-53).”
Backgroundvon Büdingen, H. ‐., Palanichamy, A., Lehmann‐Horn, K., Michel, B., & Zamvil, S. S. (2015) · European Neurology · doi:10.1159/000377675 · Cited by 1,475
Cited by
Sorted by citations
B cell regulation in cancer and anti-tumor immunity
Sarvaria, A., Madrigal, J. A., & Saudemont, A. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.35 · Cited by 652
Antibody-independent functions of B cells: a focus on cytokines
Shen, P., & Fillatreau, S. (2015) · Nature Reviews Immunology · doi:10.1038/nri3857 · Cited by 508
B cells responses and cytokine production are regulated by their immune microenvironment
Vazquez, M. I., Catalan-Dibene, J., & Zlotnik, A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.02.007 · Cited by 421
“These data are reminiscent of animal studies where Breg cells have been shown to lead to the resolution of colitis in mice [88].”
BackgroundResultImmunosuppressive Mechanisms of Regulatory B Cells
Catalán, D., Mansilla, M. A., Ferrier, A., Soto, L., Oļeiņika, K., Aguillón, J. C., & Aravena, O. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.611795 · Cited by 429
“Besides, murine IL-10 Bregs can prevent the recruitment of neutrophils to the sites of inflammation in a model of colitis (42).”
BackgroundInfluentialB10 Cells: A Functionally Defined Regulatory B Cell Subset
Tedder, T. F. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401329 · Cited by 290
“Whether these regulatory activities and mechanisms of action are attributable to a single B cell subset or functionally diverse B cell populations during IBD is unresolved.”
BackgroundResultInfluentialSelf-citation
Metadata
- Authors
- Maseda, D., Candando, K. M., Smith, S. H., Kalampokis, I., Weaver, C. T., Plevy, S. E., Poe, J. C., & Tedder, T. F.
- Affiliations
- Department of Immunology, Duke University Medical Center , Durham, NC 27710
- Duke Medical Center (US)
- University of Alabama at Birmingham (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Tedder, Thomas F
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-09-01
- Volume
- 191
- Issue
- 5
- Pages
- 2780-2795
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3770313
- OpenAlex
- W2170857080
- Cited by
- 144
- References
- 73
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 13 · 2019: 18 · 2018: 11 · 2017: 14 · 2016: 17 · 2015: 21 · 2014: 12 · 2013: 1
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30CA016086)
- National Institute of Allergy and Infectious Diseases (AI 057157, U54AI057157, U19AI056363, AI-56363)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK054452, R01DK054452)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- regulatory B cells, B10 cells, peritoneal cavity, IL-10, colitis, B cell subsets, B cell receptor repertoire, commensal microbiota, neutrophil infiltration, inflammatory cytokines, gut immune homeostasis
- MeSH terms
- Animals, Colitis, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Fluorescent Antibody Technique, Interferon-gamma, Male, Mice, Inbred C57BL, Peritoneal Cavity, CD4-Positive T-Lymphocytes, Lymphocyte Subsets, Interleukin-10, Mice, Knockout, Adoptive Transfer, Mice, B-Lymphocytes, Regulatory
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