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Mast cells are dispensable for normal and activin‐promoted wound healing and skin carcinogenesis

Antsiferova, Maria, Martin, Caroline, Huber, Marcel, Feyerabend, Thorsten B, Förster, Anja, Hartmann, Karin, Rodewald, Hans-Reimer, Hohl, Daniel, Werner, Sabine·2013·The Journal of Immunology
DOI 10.4049/jimmunol.1301350
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Abstract

The growth and differentiation factor activin A is a key regulator of tissue repair, inflammation, fibrosis, and tumorigenesis. However, the cellular targets, which mediate the different activin functions, are still largely unknown. In this study, we show that activin increases the number of mature mast cells in mouse skin in vivo. To determine the relevance of this finding for wound healing and skin carcinogenesis, we mated activin transgenic mice with CreMaster mice, which are characterized by Cre recombinase-mediated mast cell eradication. Using single- and double-mutant mice, we show that loss of mast cells neither affected the stimulatory effect of overexpressed activin on granulation tissue formation and reepithelialization of skin wounds nor its protumorigenic activity in a model of chemically induced skin carcinogenesis. Furthermore, mast cell deficiency did not alter wounding-induced inflammation and new tissue formation or chemically induced angiogenesis and tumorigenesis in mice with normal activin levels. These findings reveal that mast cells are not major targets of activin during wound healing and skin cancer development and also argue against nonredundant functions of mast cells in wound healing and skin carcinogenesis in general.

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Research works printed but not linked: 39

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Metadata

Authors
Antsiferova, M., Martin, C., Huber, M., Feyerabend, T. B., Förster, A., Hartmann, K., Rodewald, H.-R., Hohl, D., & Werner, S.
Affiliations
  • Department of Biology, Institute of Molecular Health Sciences, Swiss Federal Institute of Technology Zurich , 8093 Zürich,
  • Department of Dermatology, University of Lausanne , 1011 Lausanne,
  • German Cancer Research Center , 69120 Heidelberg,
  • Department of Dermatology, University of Cologne , 50937 Cologne,
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2013-12
Volume
191
Issue
12
Pages
6147-6155
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1301350
Cited by
75
References
1
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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