The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The Drosophila Imd Signaling Pathway
Abstract
The fruit fly, Drosophila melanogaster, has helped us to understand how innate immunity is activated. In addition to the Toll receptor and the Toll signaling pathway, the Drosophila immune response is regulated by another evolutionarily conserved signaling cascade, the immune deficiency (Imd) pathway, which activates NF-κB. In fact, the Imd pathway controls the expression of most of the antimicrobial peptides in Drosophila; thus, it is indispensable for normal immunity in flies. In this article, we review the current literature on the Drosophila Imd pathway, with special emphasis on its role in the (patho)physiology of different organs. We discuss the systemic response, as well as local responses, in the epithelial and mucosal surfaces and the nervous system.
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Cites
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NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
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CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
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The Drosophila Toll Signaling Pathway
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Self-citationInnate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila
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Metadata
- Authors
- Myllymäki, H., Valanne, S., & Rämet, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04
- Volume
- 192
- Issue
- 8
- Pages
- 3455-3462
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1755844030
- Cited by
- 552
- References
- 118
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- closed
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