The DOI matches its Crossref record.
Specific stimulation of human T lymphocytes by substance P.
Abstract
Substance P (SP) and SP(4-11) stimulated significantly the proliferation of human T lymphocytes in vitro at respective concentrations of 10(-11) M to 10(-7) M and 10(-9) M to 10(-7) M, as assessed by the uptake of [3H]thymidine and [3H]leucine. The proliferative response of human T lymphocytes to PHA was augmented by 10(-9) M to 10(-8) M SP and 10(-10) M to 10(-7) M SP(4-11). The inactive analogue [D-Pro2, D-Phe7, D-Trp9]-SP inhibited the effects of SP on T lymphocytes. The specific stimulation of T lymphocytes by SP suggests a unique mechanism for the regulation of immunologic responses by peripheral nerve-derived factors.
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Citations
Cited by
Neuropeptide substance P and the immune response
Mashaghi, A., Marmalidou, A., Tehrani, M., Grace, P. M., Pothoulakis, C., & Dana, R. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2293-z · Cited by 493
Hong, H. S., Lee, J., Lee, E., Kwon, Y. S., Lee, E., Ahn, W., Jiang, M. H., Kim, J. C., & Son, Y. (2009) · Nature Medicine · doi:10.1038/nm.1909 · Cited by 349
Stress, symmetry, and psoriasis: Possible role of neuropeptides
Farber, E. M., Nickoloff, B. J., Recht, B., & Fraki, J. E. (1986) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(86)70034-0 · Cited by 261
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Brain, S. D. (1997) · Immunopharmacology · doi:10.1016/s0162-3109(97)00055-6 · Cited by 246
Increased number of immunoreactive nerve fibers in atopic dermatitis
Tobin, D., Nabarro, G., de la Faute, H. B., van Vloten, W. A., van der Putte, S. C. J., & Schuurman, H.-J. (1992) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(92)90134-n · Cited by 211
Metadata
- Authors
- Payan, D. G., Brewster, D. R., & Goetzl, E. J.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1983-10-01
- Volume
- 131
- Issue
- 4
- Pages
- 1613-1615
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1855852462
- Cited by
- 459
- References
- 0
- FWCI
- 3.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Payan, D. G., Brewster, D. R., & Goetzl, E. J. (1983). Specific stimulation of human T lymphocytes by substance P. The Journal of Immunology. https://doi.org/10.4049/jimmunol.131.4.1613
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
