The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Human mast cells produce IL-8.
Abstract
Recruitment of neutrophils is a common feature in diseases that are associated with mast cell activation. The mechanisms that mediate neutrophil activation are not well understood. IL-8 is a recently described potent chemotactic factor that might be pathogenetically involved in this process. We therefore studied the human mast cell line HMCI and human skin mast cells for their ability to produce IL-8 using various stimuli. IL-8-mRNA was expressed in a stimulus- and time-dependent fashion as detected by Northern blot analysis with an IL-8-specific cDNA probe. The molecular mass of HMCI-derived IL-8 was determined to be about 8 kDa by immunoblot analysis. Immunoreactive and biologically active IL-8 protein was measured in the cell culture supernatants of HMCI cells by an ELISA and a chemotaxis assay, respectively. On immunoelectron microscopy of stimulated skin mast cells, IL-8 was found along cytoplasmatic membranes and in intracellular granules. Our data indicate that mast cells may contribute to neutrophil recruitment by secretion of IL-8.
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Cites
The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes
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Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions
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Cited by
Biedermann, T., Kneilling, M., Mailhammer, R., Maier, K., Sander, C. A., Kollias, G., Kunkel, S. L., Hültner, L., & Röcken, M. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.10.1441 · Cited by 395
Ajuebor, M. N., Das, A. M., Virág, L., Flower, R. J., Szabó, C., & Perretti, M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1685 · Cited by 300
Mast-cell responses in the development of asthma
Bingham, C. O., & Austen, K. F. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(00)90056-3 · Cited by 80
ESTROGEN REGULATES CYTOKINE RELEASE IN HUMAN MAST CELLS
Kim, M.-S., Chae, H.-J., Shin, T.-Y., Kim, H.-M., & Kim, H.-R. (2001) · Immunopharmacology and Immunotoxicology · doi:10.1081/iph-100108596 · Cited by 65
Mast cell mediators of significance in clinical practice in mastocytosis
Butterfield, J. H., Ravi, A., & Pongdee, T. (2018) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2018.04.011 · Cited by 48
Metadata
- Authors
- Möller, A., Lippert, U., Lessmann, D., Kolde, G., Hamann, K., Welker, P., Schadendorf, D., Rosenbach, T., Luger, T., & Czarnetzki, B. M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-09
- Volume
- 151
- Issue
- 6
- Pages
- 3261-3266
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1529918408
- Cited by
- 297
- References
- 12
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Human mast cells produce IL-8. https://app.cochat.ai/papers/10.4049/jimmunol.151.6.3261
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- Möller, A., Lippert, U., Lessmann, D., Kolde, G., Hamann, K., Welker, P., Schadendorf, D., Rosenbach, T., Luger, T., & Czarnetzki, B. M. (1993). Human mast cells produce IL-8. The Journal of Immunology. https://doi.org/10.4049/jimmunol.151.6.3261
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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