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Cited by 452

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Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions

Gimbrone, M. A., Obin, M. S., Brock, A. F., Luis, E. A.., Hass, P. E., Hébert, C. A., Yip, Y. K., Leung, D. W., Lowe, D. G., Kohr, W. J., Darbonne, W. C., Bechtol, K. B., Baker, J. B.·1989·Science
DOI 10.1126/science.2688092
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Abstract

Certain inflammatory stimuli render cultured human vascular endothelial cells hyperadhesive for neutrophils. This state is transient and reversible, in part because activated endothelial cells secrete a leukocyte adhesion inhibitor (LAI). LAI was identified as endothelial interleukin-8 (IL-8), the predominant species of which is an extended amino-terminal IL-8 variant. At nanomolar concentrations, purified endothelial IL-8 and recombinant human IL-8 inhibit neutrophil adhesion to cytokine-activated endothelial monolayers and protect these monolayers from neutrophil-mediated damage. These findings suggest that endothelial-derived IL-8 may function to attenuate inflammatory events at the interface between vessel wall and blood.

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Research works printed but not linked: 30

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Metadata

Authors
Gimbrone, M. A., Obin, M. S., Brock, A. F., Luis, E. A., Hass, P. E., Hébert, C. A., Yip, Y. K., Leung, D. W., Lowe, D. G., Kohr, W. J., Darbonne, W. C., Bechtol, K. B., & Baker, J. B.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-12-22
Volume
246
Issue
4937
Pages
1601-1603
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2688092
OpenAlex
W2079289760
Cited by
452
References
0
FWCI
10.39
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions. https://app.cochat.ai/papers/10.1126/science.2688092
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Gimbrone, M. A., Obin, M. S., Brock, A. F., Luis, E. A., Hass, P. E., Hébert, C. A., Yip, Y. K., Leung, D. W., Lowe, D. G., Kohr, W. J., Darbonne, W. C., Bechtol, K. B., & Baker, J. B. (1989). Endothelial Interleukin-8: A Novel Inhibitor of Leukocyte-Endothelial Interactions. Science. https://doi.org/10.1126/science.2688092

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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