Requirement for Ras Guanine Nucleotide Releasing Protein 3 in Coupling Phospholipase C-γ2 to Ras in B Cell Receptor Signaling
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Two important Ras guanine nucleotide exchange factors, Son of sevenless (Sos) and Ras guanine nucleotide releasing protein (RasGRP), have been implicated in controlling Ras activation when cell surface receptors are stimulated. To address the specificity or redundancy of these exchange factors, we have generated Sos1/Sos2 double- or RasGRP3-deficient B cell lines and determined their ability to mediate Ras activation upon B cell receptor (BCR) stimulation. The BCR requires RasGRP3; in contrast, epidermal growth factor receptor is dependent on Sos1 and Sos2. Furthermore, we show that BCR-induced recruitment of RasGRP3 to the membrane and the subsequent Ras activation are significantly attenuated in phospholipase C-γ2–deficient B cells. This defective Ras activation is suppressed by the expression of RasGRP3 as a membrane-attached form, suggesting that phospholipase C-γ2 regulates RasGRP3 localization and thereby Ras activation.
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Several biochemical pathways and processes negatively regulate PLCγ2 activity and calcium flux after BCR engagement, including RasGRP3, Bam32, Dok-3 with Grb2, Themis2, BLNK, and SFRP2.
“Several biochemical pathways and processes were shown to negatively regulate PLCγ2 activity and the resulting calcium flux after BCR engagement. These include RasGRP3 (39, 40), Bam32 (41), hematopoietic adaptor protein Dok-3 (downstream of kinase-3) with Grb2 (42), Themis2, an adaptor protein with no known enzymatic activity, via constitutive binding to Lyn, Grb2, and PLCγ2 to mediate its function”
From The role of PLCγ2 in immunological disorders, cancer, and neurodegeneration (2021) · cites this paper as [39]
The citation to this paper is attached to RasGRP3, not the other listed proteins. In the Results (Figure 5 and accompanying text), BCR-induced IP3 generation and calcium mobilization were unaffected by RasGRP3 deficiency; the Discussion instead places RasGRP3 downstream of PLC-γ2 in Ras activation. (LLM, conf=0.90)
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- Authors
- Oh-hora, M., Johmura, S., Hashimoto, A., Hikida, M., & Kurosaki, T.
- Affiliations
- 1Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi 570-8506, Japan
- Kansai Medical University (JP)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2003-12-15
- Volume
- 198
- Issue
- 12
- Pages
- 1841-1851
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2194160
- OpenAlex
- W2131566341
- Cited by
- 113
- References
- 69
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc-sa
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Uehara Memorial Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- RasGRP3, SOS1, SOS2, Ras guanine nucleotide exchange factor, Ras activation, B cell receptor signaling, PLCγ2, epidermal growth factor receptor, membrane recruitment, B-cell lines
- MeSH terms
- Amino Acid Sequence, Animals, Mice, Inbred C57BL, Molecular Sequence Data, Type C Phospholipases, Receptors, Antigen, B-Cell, Signal Transduction, ras Proteins, Guanine Nucleotide Exchange Factors, ras Guanine Nucleotide Exchange Factors, Son of Sevenless Proteins, SOS1 Protein, Mice, Phospholipase C gamma
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