Cited by 859Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

The DOI matches its Crossref record.

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

Hiyama, K, Hirai, Y, Kyoizumi, S, Akiyama, M, Hiyama, E, Piatyszek, M A, Shay, J W, Ishioka, S, Yamakido, M·1995·The Journal of Immunology

DOI 10.4049/jimmunol.155.8.3711

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Abstract

This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.

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“Telomerase activity has been shown in lymphocytes, haematopoietic progenitor cell”
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Self-citation
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BackgroundInfluential
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Background
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Background
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Background
Human telomerase reverse transcriptase-specific T-helper responses induced by promiscuous major histocompatibility complex class II-restricted epitopes.
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BackgroundSelf-citation
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“Somatic cells do not express telomerase, with few exceptions such as proliferating cells in the hematopoietic system [37,38].”
Background
High susceptibility of a human breast epithelial cell type with stem cell characteristics to telomerase activation and immortalization.
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“(Broccoli et al., 1995; Hiyama et al., 1995) exhibit telomerase activity, expression is similar to that recognized by a previously reported polyclonal antibody (Vaziri et al., 1999) (”
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“highly replicative cells of skin (11), gastrointestinal tractstomach-intestine (12), bone marrow (13), testes (14), and generally in all systems affected in the telomerase disorder, Dyskeratosis Congenita.”
BackgroundSelf-citation
Telomere Length Dynamics and the Evolution of Cancer Genome Architecture
Cleal, K., Norris, K., & Baird, D. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020482 · Cited by 77
“reverse trascriptase TERT subunit and TERC, the RNA template from which TERT can actively 53 add telomere repeats to the chromosome terminus [13-16].”
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Changes in Telomerase Activity and Telomere Length during Human T Lymphocyte Senescence
Pan, C.-X., Xue, B.-H., Ellis, T. M., Peace, D. J., & Dı́az, M. O. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3475 · Cited by 68
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“The majority of samples from esophagus, stomach, and colon were negative (Takubo et al. 1997; Maruyama et al. 1997; Tahara et al. 1995; Ahn et al. 1997; Hiyama E. et al. 1995; Chadeneau et al. 1995; Yoshida et al. 1997), while Hiyama and coworkers were able to demonstrate telomerase activity in all colon samples of he…”
MethodInfluential
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BackgroundSelf-citation
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“Similar mechanisms were described in activated lymphocytes.(37) None of the chondrocyte cell lines revealed continuous telomerase expression or an activation of the enzyme in later passages.”
Background
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Devesa, S. S., Blot, W. J., & Fraumeni, J. F. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981115)83:10 · Cited by 2,097
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“32 Hiyama, K. et al. (1995) Activation of telomerase in human”
Background
Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests
Preto, A., Cameselle‐Teijeiro, J., Moldes-Boullosa, J., Soares, P., Teijeiro, J. F. C., Silva, P., Reis-Filho, J. S., Reyes-Santías, R., Alfonsín-Barreiro, N., Forteza, J., et al. (2004) · Modern Pathology · doi:10.1038/modpathol.3800124 · Cited by 64
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“Higher telomerase activity can be detected in the bone marrow (BM) CD34 + CD38 + committed progenitor cell fraction than in the CD34 + CD38 −/low fraction containing primitive hematopoietic progenitor cells (Hiyama et al. 1995).”
Background
Telomerase Expression in Noncancerous Bronchial Epithelia Is a Possible Marker of Early Development of Lung Cancer
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“Moreover, detection of telomerase activity in clinical materials without in situ analysis may cause a false positive due to the infiltrated lymphocytes (16).”
BackgroundSelf-citation
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“Furthermore, this reduced cycling minimizes the uncapping of telomeres during replication (35-37) and telomeres are further protected in stem cells by the expression of telomerase (36, 38, 39).”
Background
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Application of telomerase assay for the screening of cervical lesions.
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“In the latter, telomerase activity is readily detectable in lymphocytes,((8)) which need to undergo rapid expansion, and in stem cells.((9,10)) Nevertheless there is evidence that telomeres do shorten during replicative aging of”
Background
Molecular Mechanisms of Immunosenescene and Inflammaging: Relevance to the Immunopathogenesis and Treatment of Multiple Sclerosis
Perdaens, O., & Pesch, V. V. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.811518 · Cited by 62
“Telomerase activity is increased in stem cells, but also in lymphocytes, where it is the highest in the germinal center (122, 123).”
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Mitogen-Activated Protein Kinase Cascade-Mediated Histone H3 Phosphorylation Is Critical for Telomerase Reverse Transcriptase Expression/Telomerase Activation Induced by Proliferation
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“Previous studies have shown that activated T cells undergo up-regulation of hTERT mRNA expression and of telomerase activity (3, 16, 19, 39).”
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Telomere biology in hematopoiesis and stem cell transplantation
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Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid
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“Absent from most of normal somatic cells, with exception of germ cells, stem cells and activated haematopoietic (Hiyama et al, 1995), telomerase is expressed in most tumou lines and in a majority of cancer.”
BackgroundResult
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Background
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Background

Authors: Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M.
Affiliations: Hiroshima University (JP)
ORCID: Akiyama, M
Hiyama, E
Piatyszek, M A
Shay, J W
Ishioka, S
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1995-10
Volume: 155
Issue: 8
Pages: 3711-3715
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.155.8.3711
OpenAlex: W1516272650
Cited by: 853
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 17 · 2013: 20 · 2012: 17
FWCI: 38.21
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG07992, R01AG007992)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: telomerase, telomerase activity, lymphocytes, T cells, B cells, hematopoietic progenitor cells, mitogen stimulation, aging, cellular senescence, telomere length, carcinogenesis, normal cells
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Base Sequence, Bone Marrow Cells, Cell Separation, Child, Child, Preschool, Enzyme Activation, Hematopoietic Stem Cells, Humans, Infant, Infant, Newborn, Leukocytes, Mononuclear, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Molecular Sequence Data, Telomerase

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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

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