The DOI matches its Crossref record.
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells
Abstract
This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.
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“Although we have to wait for the final report of the clinical trial, no significant adverse effects on normal tissues have been reported so far, even in hematopoietic cells, which may be highly susceptible to Telomelysin due to the presence of telomerase-positive stem cells. (35)”
From Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers (2008) · cites this paper as [35]
In the citing paper
“We should consider the fact that some normal cells, including some tissue stem cells, express relatively high levels of telomerase, (35,36,117) raising questions regarding the safety of Telomelysin.”
From Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers (2008) · cites this paper as [35]
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Items 701–800 of 859
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Telomerase Activity of Peripheral Blood Mononuclear Cells From Patients With Laryngeal Carcinoma
Ge, P., Zhang, B., Zhang, J., et al. (2004) · American Journal of Clinical Oncology · doi:10.1097/01.coc.0000054893.83191.60 · Cited by 5
“Conversely, telomerase activity was not detected in the untreated specimens from laryngeal cancer patients and volunteers (data not shown).(9,16) Although the action of PHA is not well known, it binds to component chains of TCR.”
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Telomere and Telomerase for the Regulation of Stem Cells
Hiyama, E., & Hiyama, K. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-227-8_11 · Cited by 4
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“Some cells, including lymphocytes, germ cells, stem cells and unicellular eukaryotes such as yeast, express the enzyme telomerase, which gives them the ability to replenish their telomeres and give them further replicative potential [30, 44].”
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“Ge et al.29 showed that although PHA stimulated both proliferation and telomerase activity of PBMC, the telomerase activity was not strictly proportional to the proliferative response to PHA.”
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“[32] Moreover, a very recent study has demonstrated that cient to mobilize telomerase from nucleoli to the nucleoplasm.”
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BackgroundTargeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer
Fujiwara, T. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6102-0_6 · Cited by 2
“Tumor cells are able to maintain telomere length predominantly due to telomerase, and its activity is detected in about 85% of malignant tumors (Shay and Bacchetti 1997), whereas telomerase is absent in most normal somatic tissues (Dong et al. 2005), with a few exceptions, including peripheral blood leukocytes and cer…”
Background(2010) · CRC Press eBooks · doi:10.1201/ebk1439813423-c3 · Cited by 2
Carlund, O., Norberg, A., Osterman, P., Andersson, I., Eriksson, A., Degerman, S., & Hultdin, M. (2025) · Scientific Reports · doi:10.1038/s41598-025-12566-7 · Cited by 2
“It is well-known that telomere length decreases with age in normal blood cells 10,16,33 but there is conflicting data regarding the association between TA and age in normal activated lymphocytes 30,34,35 .”
Barbé‐Tuana, F. M., Grün, L. K., Pierdoná, V., de Oliveira, B. C. D., de Paiva, S. C., Shiburah, M. E., da Silva, V. L., Morea, E. G. O., Fontes, V. S., & Cano, M. I. N. (2021) · Springer eBooks · doi:10.1007/978-3-030-73151-9_7 · Cited by 2
Telomerase Mutations and Premature Ageing in Humans
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“Telomeres were observed to shorten in human tissues, including peripheral blood cells, liver, kidney, spleen, dermal fibroblasts, and mucosal keratinocytes (Broccoli et al. 1995, Hiyama et al. 1995, Harle-Bachor and Boukamp 1996, Yasumoto et al. 1996).”
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Eskandari‐Nasab, E., Dahmardeh, F., Rezaeifar, A., et al. (2015) · Gene Cell and Tissue · doi:10.17795/gct28084 · Cited by 2
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Alam, S., Katakura, Y., Yoshida, H., et al. (2000) · Cytotechnology · doi:10.1023/a:1008171109981 · Cited by 2
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A different approach to telomere analysis with ddPRINS in chronic lymphocytic leukemia
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“Volume 4(11) 360-367 (2012) - 361 J Cancer Sci Ther ISSN:1948-5956 JCST, an open access journal In most human normal somatic cells, telomerase activity is undetectable [21].”
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Measurement of Telomerase Activity in Human Hematopoietic Cells and Neoplastic Disorders
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TELOMERES AND ARTERIAL HYPERTENSION: PATHOPHYSIOLOGY AND CLINICAL PERSPECTIVES
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“However, upon activation, the lymphocytes up-regulate the telomerase activity (9,11).”
BackgroundTelomerase and Malignant Transformation
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“A recent report of telomerase activation in lymphocytes and other cells in the absence of malignant transformation has attracted attention.(4) Lymphocyte activation is associated with elevated telomerase activity.”
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AlMansoori, M. E., Awad, A., Dhaiban, S., Alduhoori, M. T., Sharif, H., & Sajini, A. A. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1681988 · Cited by 1
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“In all cases, the false-positives were associated with inflammatory processes, perhaps reflecting the presence of activated lymphocytes that have been shown to be capable of expressing telomerase.(11) Such activated lymphocytes might have been a confounding variable in our study.”
ResultDesign and Synthesis of Polyoxazole‐based Macrocycles Tethered with a Phosphonate Group
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Background
Metadata
- Authors
- Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M.
- Affiliations
- Hiroshima University (JP)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-10
- Volume
- 155
- Issue
- 8
- Pages
- 3711-3715
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1516272650
- Cited by
- 853
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 17 · 2013: 20 · 2012: 17
- FWCI
- 38.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG07992, R01AG007992)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase, telomerase activity, lymphocytes, T cells, B cells, hematopoietic progenitor cells, mitogen stimulation, aging, cellular senescence, telomere length, carcinogenesis, normal cells
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Base Sequence, Bone Marrow Cells, Cell Separation, Child, Child, Preschool, Enzyme Activation, Hematopoietic Stem Cells, Humans, Infant, Infant, Newborn, Leukocytes, Mononuclear, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Molecular Sequence Data, Telomerase
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