Cited by 859Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsNuclear Structure and Function

The DOI matches its Crossref record.

Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

Hiyama, K, Hirai, Y, Kyoizumi, S, Akiyama, M, Hiyama, E, Piatyszek, M A, Shay, J W, Ishioka, S, Yamakido, M·1995·The Journal of Immunology

DOI 10.4049/jimmunol.155.8.3711

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Abstract

This is the first report describing up-regulation of telomerase activity in human normal cells. Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining telomere length stability in germline and most cancer cells, but not in normal cells. However, in the present study, we demonstrate that telomerase activity is detectable at low levels in normal human T and B cells, increases by in vitro mitogenic stimulation, increases in hematopoietic progenitor cells upon their proliferation and differentiation, and decreases with aging. Understanding the regulation of telomerase activity in normal cells may provide important insights not only into the mechanisms of normal cellular senescence but also into the mechanisms of telomerase activity deregulation as part of cancer development.

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“Second, the on-target and off-tumor crossreactivity for hTERT peptides would be predicted to most likely affect hematopoietic and/or germ cells since the protein is not normally expressed in other tissues.(43,47) However, our assays did not detect any toxicity against hematopoietic stem cells.”
Background
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Lifespans of T lymphocytes
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“However telomerase is up regulated following immune stimulation of B and T cells [42-46], this is sufficient to reduce the rate of telomere erosion, and”
Background
Increases in T Cell Telomere Length in HIV Infection after Antiretroviral Combination Therapy for HIV-1 Infection Implicate Distinct Population Dynamics in CD4+ and CD8+ T Cells
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Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count
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Self-citation
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“It is also detectable at low levels in normal human Tand B cells [27], and there is evidence showing that telomerase expression between PBMC and pancreatic islets is correlated, which suggests its potential as a biomarker to indicate the ability of metabolic cells including pancreatic β cells to replicate [12].”
Background
Effects of rare earth elements on telomerase activity and apoptosis of human peripheral blood mononuclear cells
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Background
Telomere Length Among the Elderly and Oldest-Old
Bischoff, C., Graakjær, J., Petersen, H. C., Jeune, B., Bohr, V. A., Kølvraa, S., & Christensen, K. (2005) · Twin Research and Human Genetics · doi:10.1375/twin.8.5.425 · Cited by 39
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Background
Telomerase, immortality and cancer
Krupp, G., Bonatz, G., & Parwaresch, R. M. (2000) · Biotechnology annual review · doi:10.1016/s1387-2656(00)06020-8 · Cited by 35
Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status
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“In addition, telomerase is transiently up-regulated in stimulated lymphocytes (Hiyama et al., 1995).”
Background
Telomerase assay for differentiating between malignancy-related and nonmalignant ascites.
Tangkijvanich, P., Tresukosol, D., Sampatanukul, P., Sakdikul, S., Voravud, N., Mahachai, V., & Mutirangura, A. (1999) · PubMed · Cited by 33
In situ mRNA Hybridization Technique for Analysis of Human Telomerase RNA in Gastric Precancerous and Cancerous Lesions
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“These results suggest that normal lymphocytes in the regional lymph nodes could be strictly protected from OBP-301-induced oncolysis, because lymphocytes are not permissive for OBP-301 infection and viral replication is also unlikely to occur in normal cells due to their low telomerase activity.(25) Previously, we use…”
Method
Inhibition of UBE2D3 Expression Attenuates Radiosensitivity of MCF-7 Human Breast Cancer Cells by Increasing hTERT Expression and Activity
Wang, W., Yang, L., Liu, H., Li, F., Ren, L. M., Yu, H., Liu, Y., Xia, L., Han, L., Liao, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064660 · Cited by 31
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“This phenomenon occurs in every cell of the body, except in adult stem cells and cells with massive replication potential such as activated lymphocytes [16,17].”
Background
Immunotherapy and prostate cancer
Kaminski, J., Summers, J. B., Ward, M. B., Huber, M., & Minev, B. (2003) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(03)00005-7 · Cited by 32
Cancer‐selective induction of cytotoxicity by tissue‐specific expression of targeted trans‐splicing ribozyme
Song, M.-S., & Lee, S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.08.021 · Cited by 32
“ing normal cells, including germ cells and stem cells, will be also telomerase-positive [28].”
Background
Telomerase activity significantly correlates with cell differentiation, proliferation and lymph node metastasis in colorectal carcinomas
Okayasu, I., Mitomi, H., Yamashita, K., et al. (1998) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s004320050197 · Cited by 32
Quality of life in patients undergoing salvage procedures for locally recurrent prostate cancer
Tefilli, M. V., Gheiler, E. L., Tiguert, R., Barroso, U., Barton, C. D., Wood, D. P., & Pontes, J. E. (1998) · Journal of Surgical Oncology · doi:10.1002/(sici)1096-9098(199811)69:3 · Cited by 34
Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription
Finnon, P., Silver, A. R., & Bouffler, S. D. (2000) · Carcinogenesis · doi:10.1093/carcin/21.4.573 · Cited by 32
Telomeres and Telomerase in Normal and Malignant Haematologic Cells
Leber, B. F., & Bacchetti, S. (1996) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428199609045709 · Cited by 30
Telomerase in cancer: Clinical applications
Urquidi, V., Tarin, D., & Goodison, S. (1998) · Annals of Medicine · doi:10.3109/07853899809002483 · Cited by 29
Telomerase Activity in Papanicolaou Smear-Negative Exfoliated Cervical Cells and Its Association with Lesions and Oncogenic Human Papillomaviruses
Zheng, P.-S., Iwasaka, T., Zhang, Z.-M., Pater, A., & Sugimori, H. (2000) · Gynecologic Oncology · doi:10.1006/gyno.2000.5779 · Cited by 31
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Concordant expression of the telomerase-associated genes in non-small cell lung cancer
Hsu, C.-P., Miaw, J., Hsia, J., Shai, S., & Chen, C. (2003) · European Journal of Surgical Oncology · doi:10.1016/s0748-7983(03)00108-2 · Cited by 31
Progressive Telomere Shortening in Aplastic Anemia
Ball, S. E., Gibson, F. M., Rizzo, S., et al. (1998) · Blood · doi:10.1182/blood.v91.10.3582.3582_3582_3592 · Cited by 30
Role of human T‐cell leukemia virus type I Tax in expression of the human telomerase reverse transcriptase (hTERT) gene in human T‐cells
Hara, T., Matsumura‐Arioka, Y., Ohtani, K., & Nakamura, M. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2008.00798.x · Cited by 32
Marked telomere shortening in mobilized peripheral blood progenitor cells (PBPC) following two tightly spaced high-dose chemotherapy courses with G-CSF
Ricca, I., Compagno, M., Ladetto, M., Rocci, A., Dell'Aquila, M., Omedè, P., Marco, F. D., D’Antico, S., Caracciolo, D., Ferrero, D., et al. (2005) · Leukemia · doi:10.1038/sj.leu.2403652 · Cited by 29
Telomerase reverse transcriptase (TERT) expression and proliferation in canine brain tumours
Long, S., Argyle, D. J., Nixon, C., et al. (2006) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2006.00776.x · Cited by 30
Delivering antisense telomerase RNA by a hybrid adenovirus/ adeno-associated virus significantly suppresses the malignant phenotype and enhances cell apoptosis of human breast cancer cells
Zhang, X., Chen, Z., Chen, Y., & Tong, T. (2003) · Oncogene · doi:10.1038/sj.onc.1206317 · Cited by 30
Telomerase expression and telomere length in immortal leukocyte lines from channel catfish
Barker, K. S., Quiniou, S. M. A., Wilson, M. R., Bengtén, E., Stuge, T. B., Warr, G. W., Clem, L. W., & Miller, N. W. (2000) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(00)00021-5 · Cited by 31
Telomerase activation in colorectal carcinogenesis
Yan, P., Saraga, E. P., Bouzourène, H., Bosman, F. T., & Benhattar, J. (1999) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199910)189:2 · Cited by 27
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Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells
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Postnatal stem cell survival: does the niche, a rare harbor where to resist the ebb tide of differentiation, also provide lineage-specific instructions?
Kindler, V. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0505272 · Cited by 28
Stem cell factor activates telomerase in mouse mitotic spermatogonia and in primordial germ cells
Dolci, S., Levati, L., Pellegrini, M., Faraoni, I., Graziani, G., Carlo, A. D., & Geremia, R. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.8.1643 · Cited by 28
What are cancer patients willing to pay for prophylactic epoetin alfa?
Ortega, A., Dranitsaris, G., & Puodziunas, A. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19981215)83:12 · Cited by 63
As Epidermal Stem Cells Age they do not Substantially Change their Characteristics
Liang, L., Chinnathambi, S., Stern, M. M., Tomanek‐Chalkley, A., Manuel, T. D., & Bickenbach, J. R. (2004) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1111/j.1087-0024.2004.09309.x · Cited by 28
Telomere Dynamics and Genetic Instability in Disease Progression of Chronic Myeloid Leukemia
Ohyashiki, K., Iwama, H., Tauchi, T., Shimamoto, T., Hayashi, S., Ando, K., Kawakubo, K., & Ohyashiki, J. H. (2000) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428190009054880 · Cited by 29
Dissociation of Telomere Dynamics from Telomerase Activity in Human Thyroid Cancer Cells
Jones, C. J., Soley, A., Skinner, J. W., Gupta, J., Haughton, M. F., Wyllie, F. S., Schlumberger, M. J., Bacchetti, S., & Wynford‐Thomas, D. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.3944 · Cited by 27
Telomeres, species differences, and unusual telomeres in vertebrates: presenting challenges and opportunities to understanding telomere dynamics
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“Immune cells and hematopoietic stem cells in the blood tend to have relatively high levels of telomerase activity, though not enough to offset telomere loss [25,26].”
Background
Systematic Review of Genetic Variation in Chromosome 5p15.33 and Telomere Length as Predictive and Prognostic Biomarkers for Lung Cancer
Kachuri, L., Latifovic, L., Liu, G., & Hung, R. J. (2016) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-16-0200 · Cited by 27
“This occurs in all normal human cells with the exception of adult stem cells and activated lymphocytes (8, 9).”
Background
Telomerase regulation in hematological cancers: A matter of stemness?
Deville, L., Hillion, J., & Ségal-Bendirdjian, E. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.016 · Cited by 27
“The current knowledge on telomere and telomerase biology in cancer cells indicates that beside the acquisition of genetic defects, activation of telomerase in these cells constitutes an essential parameter in tumor progression [4-10].”
Background
Postmeiotic modifications of spermatogenic cells are accompanied by inhibition of telomerase activity
Yamamoto, Y., Sofikitis, N., Ono, K., et al. (1999) · Urological Research · doi:10.1007/s002400050160 · Cited by 27
“We determined the RTA of a given testicular fragment by estimating the number of cells necessary for demonstration of a telomerase activity ladder of equivalent intensity to that obtained using a positive control sample (1000 human uterine cervical cancer cells) [10].”
BackgroundMethodInfluential
Telomerase expression in uveal melanoma
Heine, B. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.2.217 · Cited by 26
Telomerase activity detected in oral lichen planus by RNA in situ hybridisation: not a marker for malignant transformation
O’Flatharta, C., Leader, M., Kay, E., Flint, S. R., Toner, M., Robertson, W., & Mabruk, M. J. E. M. F. (2002) · Journal of Clinical Pathology · doi:10.1136/jcp.55.8.602 · Cited by 27
Telomerase activity in thyroid neoplasms evaluated by the expression of human telomerase reverse transcriptase (hTERT).
Ito, Y., Yoshida, H., Tomoda, C., Uruno, T., Takamura, Y., Miya, A., Kobayashi, K., Matsuzuka, F., Kuma, K., & Miyauchi, A. (2005) · PubMed · Cited by 27
Telomeres and HIV-1 infection: in search of exhaustion
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Developmentally Regulated Telomerase Activity Is Correlated with Chromosomal Healing during Chromatin Diminution in Ascaris suum
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“In humans, on the other hand, telomerase activity is regulated during development and is involved in conferring long-term proliferation capacity on regenerative tissues, such as blood stem cells (9, 13, 29), and the germ line (31, 74).”
Background
Telomere Biology of Human Hematopoietic Stem Cells
Elwood, N. J. (2004) · Cancer Control · doi:10.1177/107327480401100214 · Cited by 26
Telomerase activity in acute myelogenous leukaemia: clinical and biological implications
Seol, J. G., Kim, E. S., Park, W. H., Jung, C. W., Kim, B. K., & Lee, Y. Y. (1998) · British Journal of Haematology · doi:10.1046/j.1365-2141.1998.00524.x · Cited by 29
“However, unlike other somatic tissues, PB, cord blood and BM leucocytes including T and B cells from normal donors were found to express low levels of telomerase activity (Counter et al, 1995; Hiyama et al, 1995).”
Background
Effects of calcium channel blockers on cellular apoptosis
Mason, R. P. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990515)85:10 · Cited by 47
DKC1 is a transcriptional target of GATA1 and drives upregulation of telomerase activity in normal human erythroblasts
Richards, L. A., Kumari, A., Knezevic, K., Thoms, J. A. I., von Jonquières, G., Napier, C. E., Ali, Z., O’Brien, R., Marks-Bluth, J., Maritz, M. F., et al. (2019) · Haematologica · doi:10.3324/haematol.2018.215699 · Cited by 25
“It is then downregulated to undetectable levels as HSPC differentiate into granulocytes, monocytes and macrophages.(9,11,12) Telomerase is similarly upregulated in lymphoid cells upon exposure to mitogens but is barely detectable in mature resting lymphocytes and peripheral blood mononuclear cells.”
BackgroundResult
A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation
Armstrong, L., Lako, M., van Herpe, I., Evans, J., Saretzki, G. C., & Hole, N. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2004.07.005 · Cited by 26
“haematopoietic stem cells and activated lymphocytes (Hiyama et al., 1995; Broccoli et al., 1995; Chiu et al., 1996), basal cells of the epidermis (Harle-Bachor and Boukamp, 1996) and intestinal crypt cells (Hiyama et al.”
Helicobacter pylori Infection: Augmentation of Telomerase Activity in Cancer and Noncancerous Tissues
Kameshima, H., Yagihashi, A., Yajima, T., et al. (2000) · World Journal of Surgery · doi:10.1007/s002680010246 · Cited by 26
Detection of telomerase activity in biopsy samples of colorectal cancer
Fang, D., Young, J. P., Luo, Y., Lu, R., & Jass, J. R. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01862.x · Cited by 24
Telomeres in the Haemopoietic System
Lansdorp, P. M., Poon, S. S. S., Chavez, E. A., Dragowska, V., Zijlmans, M., Bryan, T. M., Reddel, R. R., Egholm, M., Bacchetti, S., & Martens, U. M. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515433.ch14 · Cited by 26
A challenge for the future: aging and HIV infection
Rickabaugh, T. M., & Jamieson, B. D. (2010) · Immunologic Research · doi:10.1007/s12026-010-8167-9 · Cited by 26
Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals
Mantripragada, K. K., Caley, M. P., Stephens, P., et al. (2007) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20525 · Cited by 25
“It is possible that the elevated TA in the high grade MPNST tumors could be a result of infiltrating lymphocytes, which may express TA (Hiyama et al., 1995; Pan et al., 1997) and thus lead to falsepositive results.”
Background
Deficiency of Colonic Telomerase in Ulcerative Colitis
Usselmann, B., Newbold, M., Morris, A. G., & Nwokolo, C. U. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03752.x · Cited by 25
“Telomerase is also upregulated in activated lymphocytes (11), which are concentrated in inflamed mucosa and should increase overall telomerase expression in the colonic mucosa in ulcerative colitis.”
Background
Improved prediction of metastasis in tongue carcinomas, combining vascular and nuclear tumor parameters
Hannen, E. J. M., van der Laak, J. A. W. M., Manni, J. J., Pahlplatz, M. M. M., Freihofer, H. P. M., Slootweg, P. J., Koole, R., & de Wilde, P. C. M. (2001) · Cancer · doi:10.1002/1097-0142(20011001)92:7 · Cited by 7
Clonal Heterogeneity in Telomerase Activity and Telomere Length in Tumor-Derived Cell Lines
Savre‐Train, I., Gollahon, L., & Holt, S. E. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22354.x · Cited by 25
In Situ Detection of hTERT mRNA Relates to Ki-67 Labeling Index in Papillary Thyroid Carcinoma
Chou, S.-J., Chen, C., Harn, H., Chen, C.-J., & Liu, Y.-C. (2001) · Journal of Surgical Research · doi:10.1006/jsre.2001.6124 · Cited by 25
Examination of Telomere Lengths in Muscle Tissue Casts Doubt on Replicative Aging as Cause of Progression in Duchenne Muscular Dystrophy
Oexle, K., Zwirner, A., Freudenberg, K., Kohlschütter, A., & Speer, A. (1997) · Pediatric Research · doi:10.1203/00006450-199708000-00016 · Cited by 25
Telomerase activity in ecological studies: What are its consequences for individual physiology and is there evidence for effects and trade‐offs in wild populations
Smith, S., Hoelzl, F., Zahn, S., & Criscuolo, F. (2021) · Molecular Ecology · doi:10.1111/mec.16233 · Cited by 22
“Given the ability of immune cells to express high telomerase activity when activated (Bodnar, Kim, Effros, & Chiu, 1996; Hiyama et al., 1995; Yamada, Motoji, & Mizoguchi, 1996), future studies would benefit from a focus on immune cells, and how changes in telomerase activity ( i.e. increases) vary…”
Background
Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses
Wang, P., Leung, J., Lam, A., Lee, S., Calabrese, D. R., Hays, S. R., Golden, J. A., Kukreja, J., Singer, J. P., Wolters, P. J., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.11.012 · Cited by 24
Physiological and pathological significance of human telomerase reverse transcriptase splice variants
Bollmann, F. M. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.031 · Cited by 24
“In adults, it is detectable in the germ line [7], activated lymphocytes [8,9] and some types of stem cells [10], but is absent or almost absent in most other somatic tissues.”
Background
Oncolytic adenovirus delivering herpes simplex virus thymidine kinase suicide gene reduces the growth of human retinoblastoma in an in vivo mouse model
Ji, X., Zhang, J., Cheng, L., Wei, F., Li, H., Liu, X., Chen, X., Li, C., Wang, Y., & Huang, Q. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.03.007 · Cited by 24
“As telomerase is activated not only in tumor cells but also in stem cells, progenitor cells, germ cells and even lymphocytes in normal tissues (Hiyama et al., 1995; Liu et al., 1999; Sarin et al., 2005; Coussens et al., 2006), these cell types canpotentially be targeted by the therapeutic CRAd.”
Background
Expression of Telomerase Subunits and Localization of Telomerase Activation in Hydatidiform Mole
Nishi, H., Ohyashiki, K., Fujito, A., Yahata, N., Ohyashiki, J. H., Isaka, K., & Takayama, M. (1999) · Placenta · doi:10.1053/plac.1998.0386 · Cited by 24
“Although it was not known which cells expressed telomerase activity, we considered that trophoblasts may express strong telomerase activation as they proliferate very actively, like malignant cells, and because it was known that lymphocytes and endothelial cells had only weak telomerase activity and that fibroblasts d…”
Background
Differences in telomerase expression by the CD1a + cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease
da Costa, C., Egeler, R. M., Hoogeboom, M., Szuhai, K., Forsyth, R. G., Niesters, M., de Krijger, R. R., Tazi, A., Hogendoorn, P. C. W., & Annels, N. E. (2007) · The Journal of Pathology · doi:10.1002/path.2167 · Cited by 25
“Although telomerase expression is mainly associated with cancers and immortalized cell lines, and is therefore thought to be involved in malignant transformation and cellular immortality [33], telomerase activity can also be detected at low levels in normal bone marrow and peripheral blood lymphocytes and at higher le…”
Background
Normal T-cell telomerase activity and upregulation in human immunodeficiency virus-1 infection.
Wolthers, K. C., Otto, S. A., Wisman, G. B. A., Fleury, S., Reiss, P., ten Kate, R. W., van der Zee, A. G. J., & Miedema, F. F. (1999) · PubMed · Cited by 24
The proximal promoter region of mTert is sufficient to regulate telomerase activity in ES cells and transgenic animals
Pericuesta, E., Ramírez, M. Á., Villa, A., Relaño-Ginés, A., Torres, J. M., Nieto, M., Pintado, B., & Gutiérrez‐Adán, A. (2006) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-4-5 · Cited by 24
Detection of telomerase activity in peritoneal lavage fluid from patients with gastric cancer using immunomagnetic beads
Mori, N., Oka, M., Hazama, S., Iizuka, N., Yamamoto, K. T., Yoshino, S., Tangoku, A., Noma, T., & Hirose, K. (2000) · British Journal of Cancer · doi:10.1054/bjoc.2000.1408 · Cited by 23
“Hiyama et al (1995c) have reported that 55 (44.4”
Influential
In situ telomerase activity in pleural effusions: A promising marker for malignancy
Dejmek, A., Yahata, N., Ohyashiki, K., Ebihara, Y., Kakihana, M., Hirano, T., Kawate, N., & Kato, H. (2000) · Diagnostic Cytopathology · doi:10.1002/1097-0339(200101)24:1 · Cited by 24
Telomerase Activity in Oral Squamous Cell Carcinoma
Curran, A. J., Denis, K. S., Irish, J., Gullane, P. J., MacMillan, C., & Kamel‐Reid, S. (1998) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.124.7.784 · Cited by 24
Telomerase Activity in Candidate Stem Cells From Fetal Liver and Adult Bone Marrow
Yui, J., Chiu, C., & Lansdorp, P. M. (1998) · Blood · doi:10.1182/blood.v91.9.3255.3255_3255_3262 · Cited by 24
Telomerase Assays in the Diagnosis and Prognosis of Cancer
Shay, J. W., Werbin, H., & Wright, W. E. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515433.ch10 · Cited by 24
Self-citation
Does telomerase activity add to the value of fine needle aspirations in evaluating thyroid nodules?
Sebesta, J. A., Brown, T. A., Williard, W., et al. (2001) · The American Journal of Surgery · doi:10.1016/s0002-9610(01)00605-5 · Cited by 24
Coupling a DNA-Based Machine with Glucometer Readouts for Amplified Detection of Telomerase Activity in Cancer Cells
Wang, W., Huang, S., Li, J., Rui, K., Zhang, J., & Zhu, J. (2016) · Scientific Reports · doi:10.1038/srep23504 · Cited by 23
Reduced T-Cell Thymic Export Reflected by sj-TREC in Patients with Coronary Artery Disease
Huang, S., Ding, R., Lin, Y., He, Z., Wu, F., Dai, X., Chen, Y., Yan-ping, G. U. I., Huang, Z., Wu, Z., et al. (2016) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.31575 · Cited by 22
The role of telomerase and viruses interaction in cancer development, and telomerase-dependent therapeutic approaches
Jeda, A. S., Badrzadeh, F., Esghaei, M., & Abdoli, A. (2021) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2021.100323 · Cited by 23
Human short-term repopulating cells have enhanced telomerase reverse transcriptase expression
Järås, M., Edqvist, A., Rebetz, J., Salford, L. G., Widegren, B., & Fan, X. (2006) · Blood · doi:10.1182/blood-2005-09-008904 · Cited by 23
Telomerase Activity, Telomere Length, and Chromosome Aberrations in the Extension of Life Span of Human Embryo Cells Induced by Low-dose X-rays.
Yang, Z., Kodama, S., Suzuki, K., & Watanabe, M. (1998) · Journal of Radiation Research · doi:10.1269/jrr.39.35 · Cited by 23
Clinical implications of telomerase detection
Matthews, P., & Jones, C. J. (2001) · Histopathology · doi:10.1046/j.1365-2559.2001.01186.x · Cited by 23
“Long-lived populations such as the germ-line and stem cells, which need to divide inde®nitely, avoid the telomeric barrier to unlimited proliferation by expressing telomerase.(4) Pathological telomerase activity is also detected in the majority of malignant tumours,(5) although some tumours may maintain their telomere…”
Background
Detection of telomerase activity in breast masses by fine-needle aspiration
Pearson, A. S., Gollahon, L., O'Neal, N. C., Saboorian, H. M., Shay, J. W., & Fahey, T. J. (1998) · Annals of Surgical Oncology · doi:10.1007/bf02303853 · Cited by 22
“Telomerase activity is absent in adult tissues, with the exception of male germline and embryonal cells (19), proliferating cells of renewal tissues (20, 21), basal epidermal cells (22, 23), intestinal crypt cells (24), and activated lymphocytes (25, 26 ).”
BackgroundSelf-citation
Markers of oxidative stress and aging in Duchene muscular dystrophy patients and the possible ameliorating effect of He:Ne laser.
Abdel, S. E., Abdel-Meguid, I. E., & Korraa, S. S. (2007) · Europe PMC (PubMed Central) · Cited by 22
Telomerase Activity Significantly Correlates with Chromosome Alterations, Cell Differentiation, and Proliferation in Lung Adenocarcinomas
Fujiwara, M., Okayasu, I., Takemura, T., Tanaka, I., Masuda, R., Furuhata, Y., Noji, M., Oritsu, M., Kato, M., & Oshimura, M. (2000) · Modern Pathology · doi:10.1038/modpathol.3880125 · Cited by 22
“Furthermore, normal human lymphocytes and hematopoietic progenitor cells strongly express telomerase after mitogenic stimulation (25, 26).”
Background
The Interface between Ageing and Health in Man
Krikwood, T. B. L., & Ritter, M. A. (1997) · Age and Ageing · doi:10.1093/ageing/26.suppl_4.9 · Cited by 22
“Interestingly, odier cells whose normal function requires cell division are similarly protected, for example the haemopoietic stem cells that give rise to all the lymphocytes and accessory cells involved in immune responses [33]-”
Background
Expression of telomerase activity and oxidative stress in human hepatocellular carcinoma with cirrhosis
Liu, D.-Y. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i8.1859 · Cited by 22

Authors: Hiyama, K., Hirai, Y., Kyoizumi, S., Akiyama, M., Hiyama, E., Piatyszek, M. A., Shay, J. W., Ishioka, S., & Yamakido, M.
Affiliations: Hiroshima University (JP)
ORCID: Akiyama, M
Hiyama, E
Piatyszek, M A
Shay, J W
Ishioka, S
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1995-10
Volume: 155
Issue: 8
Pages: 3711-3715
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.155.8.3711
OpenAlex: W1516272650
Cited by: 853
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 10 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 17 · 2013: 20 · 2012: 17
FWCI: 38.21
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG07992, R01AG007992)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: telomerase, telomerase activity, lymphocytes, T cells, B cells, hematopoietic progenitor cells, mitogen stimulation, aging, cellular senescence, telomere length, carcinogenesis, normal cells
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Base Sequence, Bone Marrow Cells, Cell Separation, Child, Child, Preschool, Enzyme Activation, Hematopoietic Stem Cells, Humans, Infant, Infant, Newborn, Leukocytes, Mononuclear, Lymphocyte Activation, Lymphocytes, Male, Middle Aged, Molecular Sequence Data, Telomerase

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Activation of telomerase in human lymphocytes and hematopoietic progenitor cells

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